Prof. MD. Fulya Coşan

Education and Expertise

• 2002 - İstanbul University Istanbul Faculty of Medicine - Medical Education
• 2007 - İstanbul University Istanbul Faculty of Medicine - Internal Medicine - Specialization
• 2007 - 2011 - İstanbul University Immunology – Ph.D.
• 2009 - 2012 - Kocaeli University Faculty of Medicine - Rheumatology - Minor Specialization (Yan Dal Uzmanlık)
• 2013 - 2015 - Bülent Ecevit University Faculty of Medicine - Rheumatology
• 2016 - 2018 - Bahçeşehir University, Institute of Social Sciences, Department of Philosophy - Master's Degree
• 2018 - Bahçeşehir University Faculty of Medicine - Professorship

Professional Memberships

• Turkish Society of Internal Medicine Specialists
• Turkish Medical Association
• Turkish Society of Immunology
• International Society for Analytical Cytology (ISAC)
• Turkish Society of Rheumatology
• Turkish Osteoporosis Society
• American College of Rheumatology (International Membership)

Courses and Certificates

• 1. The Interface of Innate and Adaptive Immunity in Rheumatic Disease Course, ACR Premeeting Course (03-04.11.2017)
• 2. Bahçeşehir University Faculty of Medicine, Faculty Development Committee, Educator Development Course (01-02.10.2017)
• 3. Bahçeşehir University Faculty of Medicine, Faculty Development Committee, Educator Development Course (06-07.05.2017)
• 4. Advanced Statistics Course (03.05.2017)
• 5. EULAR Vasculitis Course (6-9.04.2016)
• 6. Genetics in Rheumatology: Diagnostic Tests and Interpretation Course (29.10.2014)
• 7. Scientific writing and publishing course (03.05.2013)
• 8. Use of Autoantibodies in the Diagnosis of Autoimmune Diseases Course (27.04.2013)
• 9. Kocaeli University III. Proteomics Course (6-10.06.2011)
• 10. MedicReS IC 2011 International Conference on ‘Good Medical Research’ (25-27.03.2011)
• 11. Kocaeli University IX. Stem Cell and Gene Therapies Research and Application Center Basic Stem Cell Techniques and Molecular Biology Course (22-26.03.2010)
• 12. Kocaeli University IX. Stem Cell and Gene Therapies Research and Application Center Applied Flow Cytometry Training (22-26.03.2010)
• 13. Good Clinical Practice for Investigational Sites E-Learning Training Certificate (05.03.2010)
• 14. Rheumatology Research and Education Association Basic Ultrasonography Course (30.04.2009)
• 15. I.U. Experimental Medicine Research Institute XIV. Applied Flow Cytometry Training (02-6.06.2008)
• 16. I.U. Experimental Medicine Research Institute Applied Laboratory Animals Course (10.02.2006)
• 17. Light Cycler 480 (Quantitative PCR Training) (26.03.2008)
• 18. Tübitak Marmara Research Center Genetic Engineering and Biotechnology Institute Applied Molecular Biology Methods Training Course (3-7.09.2007)
• 19. Istanbul Chamber of Physicians Research Planning and Basic Statistics Course (19-20.02.2005)
• 20. MS-DOS and Microsof Office 2000 Professional Training (Microsoft Authorized Center, 1 year training) (06.05.2000)

Awards (Ödüller)

1. MSD Ankylosing Spondylitis Article First Prize (2013 National Rheumatology Congress)
2. Kocaeli University 2011 Scientific Research and Incentive Award
3. A 24-Year-Old Female Patient Diagnosed with SLE; Presented with Fever, Fatigue, Pain and Swelling in Finger and Wrist Joints, and Bradycardia. Yılmazer B, Sali M, Coşan F, Çefle A. 2. National Symposium on Rheumatology Education with Cases (March 15-18, 2012, Mardin) (Poster First Prize)
4. Evaluation of Different Methods in the Application of Skin Pathergy Test. Coşan F., X. National Rheumatology Congress October 30-November 3, 2009 (2009 Rheumatology Research and Education Association Poster Award)
5. Clinical and Demographic Characteristics of 129 Patients Followed with the Diagnosis of Psoriatic Arthritis. Coşan F, Çefle A, Yazıcı A. X. National Rheumatology Congress October 30-November 3, 2009 (2009 Rheumatology Research and Education Association Poster Award)
6. Blood Surface Interaction and Aggregation of Serum Proteins During Extracorporeal Circulation with Phosphorylcholine-Coated Tubing Lines: S100A8/A9 is the trigger for inflammation? Hatemi AC, Çakiris A, Çeviker K, Canikoğlu M, Abacı N, Coşan F, Özbalcı Ç, Ağlar Ö, Azaklı H, Ökten Z, Kazan D, Kansız E, Üstek D. 2. National Congress of Artificial Organs and Support Systems April 23-26, 2009, Antalya (Oral Presentation-17) (2009 Presentation Award)
7. MEFV gene 3’UTR changes in cases due to Familial Mediterranean Fever. Üstek D., Çakiris A., Oku B., Coşan F., Abacı N., Gül A. VIII. National Genetics Congress Çanakkale-2008-PS-033 (2008 Presentation Award)
8. Association of Familial Mediterranean Fever-Related MEFV Gene M694V Mutation with Ankylosing Spondylitis. Coşan F., Tozkır J., Ustek D., Ocal L., Aral O., Gul A. (Rheumatology Research and Education Association 2006 First Prize)

Scientific Organization Memberships (Bilimsel Kuruluşlara Üyelikleri)

• Turkish Society of Internal Medicine Specialists
• Turkish Medical Association
• Turkish Society of Immunology
• International Society for Analytical Cytology (ISAC)
• Rheumatology Research and Education Association (Turkish Society of Rheumatology)
• Turkish Osteoporosis Society

Scientific Certificates (Bilimsel Sertifikalar)

• Pseudogout
• General approach to vasculitis, LCV, Hypersensitivity vasculitis
• Large vessel vasculitis: Temporal arteritis, Takayasu
• Wegener's Granulomatosis, Churg-Strauss syndrome
• PAN, mPAN
• Osteoarthritis
• Fibromyalgia
• Emergencies in Rheumatology
• Preoperative evaluation in Rheumatology
• Ocular findings of rheumatologic diseases
• Renal involvement in rheumatologic diseases
• Gastrointestinal findings of rheumatologic diseases
• Pulmonary findings of rheumatologic diseases
• Central Nervous System (CNS) findings of rheumatologic diseases

Master's Theses (Yüksek Lisans Tezleri)

• Specialty Thesis Title: THE ROLE OF MEFV GENE MUTATIONS IN THE PATHOGENESIS OF SPONDYLOARTHROPATHIES
• Advisor: Prof. Dr. Ahmet Gül

Doctoral Theses (Doktora Tezleri)

• Doctoral Thesis Title: INVESTIGATION OF THE RELATIONSHIP BETWEEN HLA-B*51 EXPRESSION AND ENDOPLASMIC RETICULUM STRESS UNDER BASAL AND STIMULATED CONDITIONS IN AN HLA-B*5 EXPRESSING MONOCYTE CELL LINE
• Advisors: Prof. Dr. Duran Üstek, Prof. Dr. Günnur Deniz

Minor Specialization Thesis (Yan Dal Uzmanlık Tezi)

• Thesis Title: INVESTIGATION OF TNFRSF1A GENE VARIATIONS IN THE PATHOGENESIS OF AMYLOIDOSIS SECONDARY TO FAMILIAL MEDITERRANEAN FEVER
• Advisor: Prof. Dr. Ayşe Çefle

Articles Published in International Peer-Reviewed Journals (Uluslararası Hakemli Dergilerde Yayınlanan Makaleler)

1. Increased frequency of IL-22 secreting Th22 cells in patients with Behçet's Disease. Çetin EA*, Coşan F*, Çefle A, Deniz G. (*Equally contibuted) Mod Rheumatol. 2014 Feb 5 [Epub ahead of print]
2. MEFV gene variations in patients with systemic lupus erythematosus. Erer B, Coşan F, Oku B, Ustek D, Inanc M, Aral O, Gul A. Mod Rheumatol. 2014 Jan;24(1):93-6.
3. Sinus node dysfunction in adult systemic lupus erythematosus flare: A case report. Yilmazer B, Sali M, Cosan F, Cefle A. Mod Rheumatol. 2013 Oct 21. [Epub ahead of print]
4. Bilateral acute sacroiliitis due to isotretinoin therapy: a case report. Yılmazer B, Coşan F, Cefle A. Int J Rheum Dis. 2013 Oct;16(5):604-5.
5. The association of TNFRSF1A gene and MEFV gene mutations with adult onset Still's disease. Cosan F, Emrence Z, Erbag G, Azakli H, Yilmazer B, Yazici A, Ekmekci SS, Abaci N, Ustek D, Cefle A. Rheumatol Int. 2013 Jul;33(7):1675-80.
6. A genome-wide analysis of lentivector integration sites using targeted sequence capture and next generation sequencing technology. Ustek D, Sirma S, Gumus E, Arikan M, Cakiris A, Abaci N, Mathew J, Emrence Z, Azakli H, Cosan F, Cakar A, Parlak M, Kursun O. Infect Genet Evol. 2012 Oct;12(7):1349-54.
7. Behçet's disease: immunological relevance with arthritis of ankylosing spondylitis. Aktas Cetin E, Cosan F, Kucuksezer UC, Bilgic S, Cagatay Y, Gul A, Deniz G. Rheumatol Int. 2012 May 11. [Epub ahead of print]
8. Hypoxia induces erythropoietin receptor expression on K562 cell line. Abaci N, Cosan F, Gulec C, Azakli H, Emrence Z, Sirma-Ekmekci S, Cakiris A, Oku B, Ustek D. Biotechnology & Biotechnological Equipment 2011;25(3):2508-2512.
9. Association of familial Mediterranean fever-related MEFV variations with ankylosing spondylitis. Cosan F, Ustek D, Oku B, Duymaz-Tozkir J, Cakiris A, Abaci N, Ocal L, Aral O, Gül A. Arthritis Rheum. 2010 Nov; 62(11): 3232-6.
10. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, Le JM, Yang B, Korman BD, Cakiris A, Aglar O, Emrence Z, Azakli H, Ustek D, Tugal-Tutkun I, Akman-Demir G, Chen W, Amos CI, Dizon MB, Kose AA, Azizlerli G, Erer B, Brand OJ, Kaklamani VG, Kaklamanis P, Ben-Chetrit E, Stanford M, Fortune F, Ghabra M, Ollier WE, Cho YH, Bang D, O'Shea J, Wallace GR, Gadina M, Kastner DL, Gül A. Nat Genet. 2010 ;42(8):698-702.
11. A novel TNFRSF1 gene mutation in a Turkish family: a report of three cases. Cosan F, Yazici A, Yılmazer B, Gul A, Ustek D, Cefle A. Clin Rheumatol. 2013 Mar;32 Suppl 1:S83-5.
12. Nilotinib efficacy in 21 imatinib-resistant or-intolerant T (9;22) positive chronic myeloid leukemia patients with and without additional chromosomal changes. Yavuz A.S., Elçioğlu Ö.C., Akpınar T., Coşan F., Uçur A., Bayrak A., Çefle K., Öztürk Ş., Palanduz Ş., Yenerel M. N., Aktan M., Nalçacı M. Nobel Med 2010; 6(2): 57-62.
13. No association of the TLR2 gene Arg753Gln polymorphism with rheumatic heart disease and Behçet's disease. Coşan F, Oku B, Cakiris A, Duymaz-Tozkir J, Mercanoğlu F, Saruhan-Direskeneli G, Ustek D, Gül A. Clin Rheumatol. 2009; 28 (12):1385-8.
14. Low-dose natural human interferon-alpha lozenges in the treatment of Behçet's syndrome. Kiliç H, Zeytin HE, Korkmaz C, Mat C, Gül A, Coşan F, Dinç A, Simşek I, Süt N, Yazici H. Rheumatology (Oxford). 2009;48(11):1388-91.
15. MEFV gene 3'-UTR Alu repeat polymorphisms in patients with familial Mediterranean fever. Ustek D, Ekmekçi C, Oku B, Coşan F, Cakiris A, Abaci N, Celik S, Kamali S, Hatemi G, Kasapçopur O, Ozdoğan H, Gül A. Clin Exp Rheumatol. 2008;26(4 Suppl 50):S72-6.
16. Prevalence and virological features of occult hepatitis B virus infection in female sex workers who work uncontrolled in Turkey. Pinarbasi B, Onel D, Coşan F, Akyuz F, Dirlik N, Cakaloglu Y, Badur S, Besisik F, Demir K, Okten A, Kaymakoglu S. Liver Int. 2009;29(2):227-30.
17. The clinical and pharmacoeconomic analysis of invasive aspergillosis in adult patients with haematological diseases. Cagatay AA, Coşan F, Karadeniz A, Besisik SK, Ozsut H, Nalcaci M, Pekcelen Y, Eraksoy H, Dincol G, Calangu S. Mycoses. 2008 Jul;51(4):328-35.
18. The meaning of increased CA125 in internal medicine practice. Bahat G, Coşan F, Saka B, Uzun S, Ozturk S, Erten N, Karan MA, Taşçıoğlu C. Nobel Med 2008; 4(3): 32-36.
19. Cloning of chimerical translocations as positive control for molecular genetic diagnosis of leukemia Ustek D, Sırma S, Cakiris A, Coşan F, Oku B, Özbek U. Turk J Hematol. 2008; 25(1): 20-23.

Presentations at International Scientific Meetings and Published in Proceedings (Uluslararası Bilimsel Toplantılarda Sunulan ve Bildiri Kitabında (Proceedings) Basılan Bildiriler)

20. The clinical significane of rarely seen staining patterns of anti nuclear antibodies. Cosan F., Ilikhan S.U., Tekin IAnn Rheum Dis 2014;73:976 doi:10.1136/annrheumdis-2014-eular.6079
21. How Could be Used the Autoantibodies Against Anti -TNF Agents in Clinical Practice ? Two Years Follow -up Study. Cosan F, Aktas Cetin E, Bilgic Gazioglu S, Yazici A, Yilmazer B, Cefle A, Deniz G. XV.Mediterranean Congress of Rheumatology, 28-31 August 2014, Clinical and Experimebntal Rheumatology 32(4) supplement 83 , P-112 (Poster Presentation), S-34, İstanbul, Turkey.
22. Cytokine Secretion and Cytotoxic Activity of NK cells in Behçet’s Disease.Aktas Cetin E, Cosan F, Akdeniz N, Cefle A, Deniz G. XV.Mediterranean Congress of Rheumatology, 28-31 August 2014, Clinical and Experimental Rheumatology 32(4) supplement 83, P-230 (Poster Presentation), S-75, İstanbul, Turkey
23. The clinical significance of rarely seen patterns of anti nuclear antibodies.Cosan F, Uygun İlikhan S, Özel Tekin İ. XV.Mediterranean Congress of Rheumatology, 28-31 August 2014, Clinical and Experimebntal Rheumatology 32(4) supplement 83 , P-145 (Poster Presentation), İstanbul, Turkey.
24. How Could be Used the Autoantibodies Against Anti -TNF Agents in Clinical Practice? Cosan F, Aktaş Çetin E, Bilgiç Gazioğlu S, Metin Gelmez Y, Yazıcı A, Yılmazer B, Işık O, Çefle A, Deniz G. 2nd International Molecular Immunology&Immunogenetics Congress (27-30 April 2014) Antalya, Turkey
25. The risk of aneurism development is higher in male patents with Takayasu arteritis. Cosan F, Doğru A, Yılmazer B, Çefle A. 5th Inflammation Forum (InForm) 4-5 April 2014, Moscow, Russia
26. The TNFRSF1A and MEFV gene mutations in the secondary amyloidosis without FMF and HPFS symptoms.Cosan F, Emrence Z, Piskinpasa SV, Odabas AR, Ustek D, Cefle A.Ann Rheum Dis 2013;72(Suppl3):76 (Oral Presentation) (Eular 2013)
27. XBP1 splicing and reduced XBP1 expression in Behçet’s Disease.Abaci N, Cosan F, Azaklı H, Sırma-Ekmekçi S, Emrence Z, Cakiris A, Ombrello MJ, Ustek D, Gül A.Ann Rheum Dis 2012;71(Suppl3):637 (EULAR 2012)
28. Cytokine secretion and cytotoxic activity of natural killer cells in Behçet’s Disease.Cosan F, Cetin EA, Akdeniz N, Emrence Z, Gecgel F, Erbag G, Doğru A, Deniz G, Cefle A.Ann Rheum Dis 2012;71(Suppl3):641 (EULAR 2012)
29. The association of HLA-B*51 expression with endoplasmic reticulum stress.Cosan F, Emrence Z, Azaklı H, Sırma S, Cetin EA, Abacı N, Ustek D.Ann Rheum Dis 2012;71(Suppl3):641 (EULAR 2012)
30. Anti-TNF using ankylosing spondylitis patients may have less severe osteoporosis.Dolasik I, Cosan F, Yilmazer B, Cefle A.Ann Rheum Dis 2012;71(Suppl3):696 (EULAR 2012)
31. Increased Th22 cells in patients with Behçet’s Disease.Cosan F, Aktas Cetin E, Cefle A, Deniz G. European Congress of Immunology, 05-08 September 2012, 94, P0904 (Poster Presentation) Glasgow, Scotland.
32. Decreased IL-17+CD16+ and IL-10+CD16+ NK cells in Behçet’s Disease. Cosan F, Aktas Cetin E, Akdeniz N, Emrence Z, Cefle A, Deniz GEuropean Congress of Immunology, 05-08 September 2012, 59, P0111(Poster Presentation) Glasgow, Scotland.
33. Decreased NK regulatory cells in children with atopic dermatitis. Aktas Cetin E, Akdeniz N, Baris S, Kosker M, Cosan F, Barlan I, Camcioglu Y, Deniz G.European Congress of Immunology, 05-08 September 2012, 90, P0779(Poster Presentation) Glasgow, Scotland.
34. The frequency of serositis in autoimmune rheumatological diseases and the differences in the response to the treatment.Cosan F, Dogru A, Dolasik I, Isik OO, Karci E, Kamis F, Yazici A, Yilmazer B, Cefle A.8th International Congress on Autoimmunity, May 9-13 2012, Granada Spain
35. The assotiation of HLA-B51 expression with endoplasmic reticulum stress . Cosan F, Emrence Z, Azaklı H, Sırma S, Aktas Cetin E, Deniz G, Ustek D.Molecular Immunology & Immunogenetics Congress (MIMIC), 27-29 April 2012, Turkish Journal of Immunology, 1(17), PP-60 (Poster presentation), 153, Antalya , Turkey.
36. Cytokine secretion of T hepler cell subsets; different aspects of Behçet’s disease. Aktas Cetin E, Cosan F, Gecgel F, Emrence Z, Akdeniz N, Cefle A, Deniz G. Molecular Immunology & Immunogenetics Congress (MIMIC), 27-29 April 2012, Turkish Journal of Immunology, 1(17), PP-19 (Poster presentation), 104, Antalya , Turkey.
37. The changes of pro-inflammatory and anti-inflammatory cytokines in latent tuberculosis infection; similarities and differences from the healthy individuals.Aktas Cetin E, Koksalan OK, Seyhan EC, Ciftci F, Cosan F, Gazioglu Bilgic S, Deniz G.Molecular Immunology & Immunogenetics Congress (MIMIC), 27-29 April 2012, PP-19 (Poster presentation), 104, Antalya , Turkey.
38. An insertion mutation in the MDFIC (MYOD family inhibitor domain containing) gene defines a novel autoinflammatory syndrome associated with lymphedema.Gül A, Ustek D, Hatemi G, Azaklı H, Emrence Z, Cosan F, Cakiris A, Abacı N, Arikan M, Cakar A, Arisoy N, Kasapcopur O, Ozdogan H.Ann Rheum Dis 2011;70(Suppl3):147 (Oral Presentation) (EULAR 2011)
39. Thrombosis in patients with systemic lupus erythematosus without findings of antiphospholipid syndrome.Cosan F, Erbag G, Ensaroğlu F, Dolasik I, Yilmazer B, Cefle A.Ann Rheum Dis 2011;70(Suppl3):733 (EULAR 2011)
40. Gender differences of ankylosing spondylitis patients receiving anti-TNF therapy.Sahinkaya Y, Cosan F, Pehlivan Ö, Omma A, Artim-Esen B, Erer B, Hüseyinsinoğlu N, Kamali S, İnanç M, Aral O, Gül A, Öcal L.Ann Rheum Dis 2011;70(Suppl3):341 (EULAR 2011)
41. Disease characteristics of spondyloarthropathies associated with anti-TNF therapy.Sahinkaya Y, Cosan F, Pehlivan O, Omma A, Artım-Esen B, Coşan F, Erer B, Hüseyinsinoğlu N, Omma A, Aral O, İnanç M, Gül A, Öcal L.Ann Rheum Dis 2011;70(Suppl3):344 (EULAR 2011)
42. The frequency of primary biliary cirrhosis and its relation to clinical findings in primary Sjögren’s syndrome.Cosan F, Isık OO, Özkanlı G, Yilmazer B, Erbag G, Cefle A.11th International Symposium on Sjögren’s syndrome, 28 September-1 October 2011, Athens, Greece.
43. Patients with anti-centromer antibody in primary Sjogren’s syndrome.Cosan F, Yılmazer B, Özkanlı G., Erbağ G., Cefle A. CORA controversies in Rheumatology and Autoimmunity, March 10-12 2011, Florence, Italy, (Poster presentation) P149 Clinical and Experimental Rheumatology 2011;29:183.
44. The liver involvement in Adult onset Still’s disease. Erbag G., Cosan F., Yilmazer B, Cefle A. CORA controversies in Rheumatology and Autoimmunity, March 10-12 2011, Florence, Italy P150 (Poster presentation) Clinical and Experimental Rheumatology 2011;29:183.
45. May beta glucan trigger autoimmunity? Systemic lupus erythematosus development after beta glucan therapy.Coşan F., Yilmazer B., Çefle A. CORA controversies in Rheumatology and Autoimmunity, March 10-12 2011, Florence, Italy, (Poster presentation) P151 Clinical and Experimental Rheumatology 2011;29:183.
46. The development of the interstitital lung disease in patients with late onset rheumatoid arthritis. Coşan F., Yilmazer B., Yazici A., Erbağ, Şimşek M, Temiz D, Dolasik I., Cefle A. CORA controverises in Rheumatology and Autoimmunity, March 10-12 2011, Florence, Italy, Poster presentation) P218, Clinical and Experimental Rheumatology 2011;29:199.
47. Anterior uveitis development in anti-TNF treatment using patients with ankylosing spondylitis. Coşan F., Erbağ G., Özkanlı G., Yılmazer B., Çefle A. CORA controverises in Rheumatology and Autoimmunity, March 10-12 2011, Florence, Italy (Poster presentation) P258 Clinical and Experimental Rheumatology 2011;29:208.
48. Whole genom screening of lentiviral vector integration sites using next generation sequencing technology. Ustek D., George J., Cakiris A., Abacı N., Sırma S., Emrence Z., Azaklı H., Coşan F., Çakar A., Parlak M., Arıkan M. Viral Vectors in Gene Therapy: Applications and Novel Production Methods. 26 August - 4 September 2010 A.I. Virtanen Institute, Kuopio, Finland
49. Copy number variation study identifies LEPREL1 (P3H2) intron 1 deletion associated with protection from multiple inflammatory diseases. Kirino Y, Ombrello MJ, Gül A, Wang K, Meguro A,Mizuki N,Yang B,Gadina M, Cosan F, Cakiris A, Abaci N, Ustek D, Siminovitch K.A. Xie G, Gregersen PK, Baldassano R.N., Kugathasan S, Polychronakos C, Ollier W.E.R., Kaklamani, Kaklamanis P, Cho Y.H., Bang D, Criswell L.A., Chung S.A., Behrens T., Graham R, Petri M, Lee A, Mayes M.D., Tan F., Assassi S., Agarwal S., Arnett F.C., Gorlova O., Varga J., Hinchcliff M., Hummers L.K., Spigarelli M.G., Grom A. A., Finkel T.H., Sullivan K.E., Satorius C., Le J.M., Sun H., Amos C.I., Tutkun I.T., Sugita S., Mochizuki M, Hama M, Takeno M, oko H., Ohno S, Ishigatsubo S., Hakonarson H, Kastner D.L., Remmers E.F. Arthritis & Rheumatism Volume 62, Number 10 (Supplement) October 2010,2217.
50. Behcet’s Disease and the Major Histocompatibility Complex: Looking beyond HLA-B51. Ombrello M.J., Kirino Y., Cosan F., Gul A., Kastner D.L., Remmers E. F.Arthritis & Rheumatism Volume 62, Number 10 ( Supplement) October 2010 (1281)
51. The TNFRSF1A Gene Variations are not associated with adult Still’s disease. Coşan F., Erbağ G., Yilmazer B., Yazıcı A., Gül A., Cefle A. Autoinflammation 2010 6th International Congress on FMF and SAID.
52. MEFV gene 3’UTR Region Alu-Repeats may have an effect on the gene expression.Emrence Z., Abacı N., Cosan F., Azaklı H., Cakiris A., Cakar A.,Erman B., Gül A., Ustek D. Autoinflammation 2010 6th International Congress on FMF and SAID.
53. Genetic predisposition for low IL-10 expression is associated with Behçet’s disease. Gul A., Kirino Y., Ustek D., Ombrello M., Cosan F., Yang B.,Gadina M., O’Shea J., Kastner D., Remmers E. Autoinflammation 2010 6th International Congress on FMF and SAID.
54. A genome wide association study identifies common variants of the IL10 and IL23R genes that contribute to Behçet’s disease susceptibility.Remmers EF, Cosan F, Kirino Y, Ombrello M, Yang B, Kaklamani VG, Ollier WER, Bang D, Wallace GR, Gadina M, Kastner DL, Gul A.14th International Conference on Behçet’s Disease, Oral Presentation, O-025, 224.
55. Genetic predisposition for low IL-10 expression is associated with Behçet’s disease.Gul A, Kirino Y, Ustek D, Ombrello MJ, Cosan F, Yang B, Gadina M, O’Shea J, Kastner DL, Remmers EF.14th International Conference on Behçet’s Disease, P-044, 302.
56. Homozygous 3.1KB deletion in LEPREL1 intron1 protects from Behçet’s disease. Kirino Y, Ombrello MJ, Gul A, Cosan F, Yang B, Gadina M, Ishigatsubo Y, Kastner DL, Remmers EF.14th International Conference on Behçet’s Disease, P-173, 243.
57. Pulmonary perfusion scintigraphy findings in Behçet’s disease.Cosan F, Adalet I, Esen BA, Aral O, Gul A.14th International Conference on Behçet’s Disease, Oral presentation, O-009, 309.
58. Pulmonary perfusion scintigraphy findings and parenchymal and/or vascular lung involvement in Behcet’s disease. Cosan F., Esen B. A., Kamali S., Aral O., Gül A. Ann Rheum Dis 2010; 69 (Suppl3):224
59. Interstitial lung disease screening with a semiquantitative method in patients with rheumatoid arthritis.Cosan F ., Yilmazer B., Erbag G., Temiz D.K., Aydin Z., Simsek M., Yazici A., Cefle A. Ann Rheum Dis 2010; 69 (Suppl3):366
60. High sedimentation rate is associated with severe disease course, deformitites and axial ankylosis in psoriatic arthritis. Cosan F., Yazici A., Cefle A. Ann Rheum Dis 2010; 69 (Suppl3):578
61. Association of Behcet's Disease with Familial Mediterranean Fever.Coşan F, Abacı N, Esen BA, Cakiris A, Ustek D, Aral O, Gül A. American College of Rheumatology/ARHP Scientific Meeting 17-21 Oct. 2009 Presentation Number: 1846 Poster Board Number: 579
62. Behçet’s Disease is Associated With MEFV Gene Mutations. Coşan F, Abaci N, Esen BA, Cakiris A, Ustek D, Aral O, Gül A. EULAR (European league against rheumatisma) The Annual European Congress of Rheumatology 2009
63. Clinical and Genetic Characteristic of Patients with Features of Both Behçet’s Disease and Familial Mediterranean Fever. Coşan F, Abaci N, Esen BA, Cakiris A, Ustek D, Aral O, Gül A. EULAR (European league against rheumatisma) The Annual European Congress of Rheumatology 2009 OP-0041 (Oral presentation)
64. Gender Difference in Late Onset Behçet’s Disease. Coşan F, Esen BA, Aral O, Gül A. EULAR (European league against rheumatisma) The Annual European Congress of Rheumatology 2009 AB0352
65. Pulmonary Artery Aneurysm Screening in Patients with Behcet’s Disease. Coşan F, Esen BA, Çağatay Y, Tunacı A, Gül A. ACR 2008 Annual Scientific Meeting, San Francisco, USA.
66. P selectin glycoprotein ligand 1 gene VNTR polymorphism and risk of thrombosis in Behçet’s disease. Coşan F., Ustek D., Abacı N., Çakiris A., Diz-Küçükkaya R.,Gül A. 13th International Conference and 5th Patients’ Convention on Behçet’s disease Austria 2008 Vol.26. No.3 2008 (Suppl. 50) (D6)
67. Parenchymal inflammatory infiltrations preceding pulmonary artery aneurysms in Behçet’s disease. Coşan F., Esen B., Cagatay Y., Kamali S., Tunacı A., Gul A. 13th International Conference and 5th Patients’ Convention on Behçet’s disease Austria 2008 Vol.26. No.3 2008 (Suppl. 50) (C8).
68. Pulmonary artery aneurysm screening in patients with Behçet’s disease. Cosan F, Esen BA, Cagatay Y, Tunacı A, Gul A.13th International Conference and 5th Patients’ Convention on Behçet’s disease Austria 2008 Vol.26. No.3 2008 (Suppl. 50) (C9)
69. Pulmonary artery aneurysms in female patients with Behçet’s disease Coşan F., Esen B., Cagatay Y., Tunacı A., Gul A. 13th International Conference and 5th Patients’ Convention on Behçet’s disease Austria 2008 Vol.26. No.3 2008 (Suppl. 50) (C10)
70. A New Simple and Sensitive Flow Cytometric Assay for the Determination of the Cytotoxic Activity of Human Natural Killer Cells: Another Approach to Anti K562 Killing Capacity. Kıran B, Üstek D, Çakiris A, Coşan F, Abacı N, Karagöz K, Demir S, Badur S. 2nd Mediterranean Clinical Immunology Meeting October 4-7 2008 (P-83)
71. The MEFV Gene Mutations may Increase the Risk of Pleuritis and Pericarditis in Patients with Systemic Lupus Erythematosus. Erer B., Cosan F., Oku B., Ustek D., Aral O., Gul A. ACR/ARHP Scientific Meeting Boston 2007 (812/64)

Articles Published in National Peer-Reviewed Journals (Ulusal Hakemli Dergilerde Yayımlanan Makaleler)

72. Ankilozan Spondilit Patogenezi. Coşan F., Gül A. Türkiye Klinikleri İmmünoloji Romatoloji cilt:3, Sayı:25 Sf:13-20 2007 (Pathogenesis of Ankylosing Spondylitis)
73. Romatoid Artrit ve Gen Tedavisi. Coşan F., Üstek D. Clinic Medicine Romatizmal Hastalıklar Özel Sayısı 2008:34-37 (Rheumatoid Arthritis and Gene Therapy)
74. Kriptojenik karaciğer sirozu-pernisiyöz anemi birlikteliği. Coşan F., Pınarbaşı B., İbrişim D., Güllüoğlu M., Demir K., Kaymakoğlu S., Çakaloğlu Y., Mungan Z. İstanbul Tıp Fakültesi Dergisi 2007; 70: 107-110. (Association of Cryptogenic Liver Cirrhosis and Pernicious Anemia)

Presentations at National Scientific Meetings and Published in Proceedings (Ulusal bilimsel toplantılarda sunulan ve bildiri kitaplarında basılan bildiriler)

75. Behçet hastalığında NK hücre sitokin polarizasyonu ve sitotoksik aktivite. Cosan F, Aktas Cetin E, Akdeniz N, Cefle A, Deniz G 22. Ulusal İmmünoloji Kongresi, 27-30 Nisan 2013, P073(Poster sunumu),115, Çeşme, İzmir. (NK cell cytokine polarization and cytotoxic activity in Behçet's disease)
76. HLA-B*51 overkespresyonu endoplazmik retikulum stresine yol açabilir mi?Coşan F., Azaklı H., Ökten Z., Sırma S., Aktaş E., Abacı N., Üstek D.Turk J Immunol–Volume:1, Number:15, Supplement (21th Congress of Immunology-Abstract Book), 2011 (Can HLA-B*51 overexpression lead to endoplasmic reticulum stress?)
77. Sistemik lupus eritematozuslu hastalarda antifosfolipid sendromu bulguları olmaksızın tromboz gelişimi. Coşan F., Erbağ G., Ensaroğlu F., Dolaşık İ., Yılmazer B., Çefle A. RAED dergisi (2010/2;40-175) (P021) (Development of thrombosis in systemic lupus erythematosus patients without antiphospholipid syndrome findings)
78. Ankilozan spondilitli 370 olgunun değerlendirilmesi. Şahinkaya Y., Pehlivan Ö., Coşan F., Artım Esen B., Erer B., Hüseyinoğlu N., Omma A., Aral O., İnanç M., Gül A., Öcal L. RAED dergisi (2010/2;40-175) (Evaluation of 370 cases with ankylosing spondylitis)
79. Anti TNF tedavi alan ankilozan spondilitli olguların değerlendirilmesi. Şahinkaya Y., Pehlivan Ö., Artım Esen B., Coşan F., Erer B., Hüseyinoğlu N., Omma A., Aral O., İnanç M., Gül A., Öcal L. RAED dergisi (2010/2;40-175) (P042) (Evaluation of ankylosing spondylitis cases receiving anti-TNF therapy)
80. Primer Sjögren sendromu olan hastalarda primer biliyer siroz sıklığı ve klinik bulgularla ilişkisi. Coşan F., Özkanlı G.,Yılmazer B., Erbağ G., Çefle A. RAED dergisi (2010/2;40-175) (P047) (Frequency of primary biliary cirrhosis in patients with primary Sjögren's syndrome and its relationship with clinical findings)
81. HLA-B5 ekspresyonu ile endoplazmik retikulum stresi arasında XBP-1 yolağı üzerinden ilişki var mı? Coşan F., Cakiris A., Emrence Z., Sırma S., Üstek D. RAED dergisi (2010/2;40-175) (P053) (Is there a relationship between HLA-B5 expression and endoplasmic reticulum stress via the XBP-1 pathway?)
82. Koroner arter fistülü ile seyreden pulmoner arter anevrizmalı Behçet hastalığı olgusu. Yılmazer B., Coşan F., Ensaroğlu F., Çefle A. RAED dergisi (2010/2;40-175) (P064) (A case of Behçet's disease with pulmonary artery aneurysm complicated by coronary artery fistula)
83. Ailevi Akdeniz ateşi patogenezinde rol oynayan pirin proteini ekspresyonunun farklı uyaranlarla değişiminin araştırılması. Coşan F., Emrence Z., Cakiris A., Üstek D.RAED dergisi (2010/2;40-175) (P091) (Investigation of changes in pyrin protein expression, which plays a role in the pathogenesis of Familial Mediterranean Fever, with different stimuli)
84. Karın ağrısı ile başvuran idyopatik aortit olgusu. Yılmazer B., Coşan F., Çefle A., Ensaroğlu F., Akansel G. RAED dergisi (2010/2;40-175) (Ö13) (A case of idiopathic aortitis presenting with abdominal pain)
85. İsoretinoin tedavisi ile ilişkili akut bilateral sakroiliit olgusu. Yılmazer B., Coşan F., Çefle A.,Akansel G. RAED dergisi (2010/2;40-175) (Ö10) (A case of acute bilateral sacroiliitis associated with isotretinoin treatment)
86. Behçet hastalığı patogenezinde doğal katil hücre sitotoksisitesinin rolüCoşan F, Aktaş Çetin E, Deniz G, Üstek D, Gül AXX. Ulusal İmmünoloji Kongresi 19-22 Kasım-Girne-Kıbrıs (Sözlü bildiri-S3) (The role of natural killer cell cytotoxicity in the pathogenesis of Behçet's disease)
87. Deri Paterji Testi Uygulamasında Farklı Yöntemlerin Değerlendirilmesi. Coşan F, Aral O, Gül AX. Ulusal Romatoloji Kongresi 30 Ekim-3 Kasım 2009 (2009 Romatoloji Araştırma ve Eğitim Derneği Poster ödülü) (Evaluation of Different Methods in the Application of Skin Pathergy Test)
88. Ailevi Akdeniz Ateşi Hastalığına Bağlı Amiloidoz Gelişen Vakalarda İmmünosupresif Tedavi. Coşan F, Artım-Esen B, Kamalı S, Aral O, Gül A. X. Ulusal Romatoloji Kongresi 30 Ekim-3 Kasım 2009 (Immunosuppressive Treatment in Cases with Amyloidosis due to Familial Mediterranean Fever)
89. Ailevi Akdeniz Ateşi Hastalığında Amiloidoz Sıklığı ve MEFV mutasyonları ile ilişkisi. Coşan F, Üstek D, Artım-Esen B, Aral O, Gül AX. Ulusal Romatoloji Kongresi 30 Ekim-3 Kasım 2009, (Sözlü Bildiri-S29) (Frequency of Amyloidosis in Familial Mediterranean Fever and its relationship with MEFV mutations)
90. Etanercept Tedavisi Sırasında Sitemik Lupus Eritematozus Gelişen Jüvenil Romatoid Artritli Hasta: Olgu Sunumu. Coşan F, Çefle A, Yazıcı A. X. Ulusal Romatoloji Kongresi 30 Ekim-3 Kasım 2009 (Juvenile Rheumatoid Arthritis Patient Developing Systemic Lupus Erythematosus during Etanercept Treatment: Case Report)
91. Psöriatik Artrit Tanısı ile İzlenmekte Olan 129 Hastanın Klinik ve Demografik Özellikleri. Coşan F, Çefle A, Yazıcı A. X. Ulusal Romatoloji Kongresi 30 Ekim-3 Kasım 2009 (2009 Romatoloji Araştırma ve Eğitim Derneği Poster ödülü) (Clinical and Demographic Characteristics of 129 Patients Followed with the Diagnosis of Psoriatic Arthritis)
92. Gluten Enteropatisi Ve Otoimmün Hipotiroidisi Olan Primer Sjögren Sendromlu Hasta: Olgu Sunumu . Yazıcı A, Çefle A, Coşan F, Şimşek M, Gürbüz Y X. Ulusal Romatoloji Kongresi 30 Ekim-3 Kasım 2009 (Primary Sjögren's Syndrome Patient with Gluten Enteropathy and Autoimmune Hypothyroidism: Case Report)
93. Adalimumab Tedavisi Sırasında Purpura Fulminans Gelişen Ankilozan Spondilitli Hasta: Olgu Sunumu. Coşan F, Çefle A, Yazıcı A, Yılmazer B, Aydın Z X. Ulusal Romatoloji Kongresi 30 Ekim-3 Kasım 2009 (Ankylosing Spondylitis Patient Developing Purpura Fulminans during Adalimumab Treatment: Case Report)
94. Romatoid Artritli 200 Hastanın Ekokardiografi Bulguları. Yazıcı A, Çefle A, Coşan F, Şahin T, Yılmazer B. X. Ulusal Romatoloji Kongresi 30 Ekim-3 Kasım 2009 (Echocardiography Findings of 200 Patients with Rheumatoid Arthritis)
95. Raynaud Fenomeni Olan ve Antinükleer Antikoru Pozitif Saptanan 40 Olgunun Klinik ve Demografik Özellikleri. Coşan F, Çefle A, Yazıcı A. X. Ulusal Romatoloji Kongresi 30 Ekim-3 Kasım 2009 (Clinical and Demographic Characteristics of 40 Cases with Raynaud's Phenomenon and Positive Antinuclear Antibody)
96. Refrakter akut miyeloblastik lösemili bir hastada tekrarlayıcı seronegatif pitting ödemli simetrik sinovit sendromu (RS3PE) Gönüllü E., Mehtap Ö., Yazıcı A., Coşan F., Hacıhanefioğlu A. 35. Ulusal Hematoloji Kongresi. 7-10 Ekim 2009-Antalya (Recurrent seronegative pitting edema with symmetric synovitis syndrome (RS3PE) in a patient with refractory acute myeloid leukemia)
97. Blood Surface Interaction and Aggregation of Serum Proteins During Extracorporeal Cırculation with Phosphorylcholine-Coated Tubing Lines: S100A8/A9 is the trigger for inflammation? Hatemi AC, Çakiris A, Çeviker K, Canikoğlu M, Abacı N, Coşan F, Özbalcı Ç, Ağlar Ö, Azaklı H, Ökten Z, Kazan D, Kansız E, Üstek D. 2. Ulusal Yapay Organlar ve Destek Sistemleri Kongresi 23-26 Nisan 2009, Antalya (Sözlü bildiri-17) (2009 Bildiri Ödülü)
98. Karaciğer transplantasyonu sonrasında kronik böbrek yetersizliği gelişmesi.Pınarbaşı B., Coşan F., Akyüz F., Ermiş F., Uyanıkoğlu A., Özden İ., Bilge O., Çakaloğlu Y., Ökten A., Kaymakoğlu S. 6th National Hepatology Meeting of TASL 2007 İstanbul. Hepatology Forum Vol1. Number 1. June 2007 (P-005) (Development of chronic renal failure after liver transplantation)
99. Üst GİS semptomu ile başvuran hastalarda malignite sıklığı; tümör tarama yaşı ne olmalı? Pınarbaşı B., Coşan F., Akyüz F., Demir K., Beşışık F., Kaymakoğlu S., Özdil S., Boztaş G., Çakaloğlu Y., Mungan Z. The Turkish Journal of Gastroenterology September 2006. Volume:17. Supplement:1 (PB.08/36) (Frequency of malignancy in patients presenting with upper GI symptoms; what should be the tumor screening age?)
100. P-Selektin Glikoprotein ligand-1 geninde yeni alelik varyasyonlar olabilir mi? Coşan F., Çakiris A., Abacı N., Ağlar Ö., Diz-Küçükkaya R., Üstek D. VIII. Ulusal Genetik Kongresi Çanakkale-2008-PS-061 (Could there be new allelic variations in the P-Selectin Glycoprotein ligand-1 gene?)
101. K562 hücre soyunda EPOR ekspresyonunun hipoksi ile indüklenmesi.Çakiris A., Abacı N., Coşan F., Oku B., Ağlar Ö., Üstek D. VIII. Ulusal Genetik Kongresi Çanakkale-2008-PS-059 (Hypoxia induction of EPOR expression in K562 cell line)
102. Hemodiyaliz hastalarında tüberkülozun klinik özellikleri. Çağatay A., Öztürk S., Karadeniz A., Coşan F., Yazici H., Çalışkan Y., Özsüt H., Ecder T., Eraksoy H., Sever M.Ş., Çalangu S. XII. Türk Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Kongresi 2005 Antalya (Clinical characteristics of tuberculosis in hemodialysis patients)
103. Akut hepatitli 245 hastanın değerlendirilmesi. Ökten A., Çakaloğlu Y., Pınarbaşı B., Coşan F., Akyüz F., Kaymakoğlu S. V. Ulusal Hepatoloji Kongresi İstanbul-2005 (P052) (Evaluation of 245 patients with acute hepatitis)
104. Spontan asit infeksiyonlu olgularımızın nüks ve prognoz yönünden değerlendirilmesi. Pınarbaşı B., Demir K., Kaymakoğlu S., Coşan F., Akyüz F., Özdil S., Beşışık F., Boztaş G., Mungan Z., Çakaloğlu Y., Ökten A.. V. Ulusal Hepatoloji Kongresi İstanbul-2005 (P016) (Evaluation of spontaneous ascites infection cases in terms of recurrence and prognosis)

Speeches Published as Full Text at National Scientific Meetings (Ulusal bilimsel toplantılarda sunulan ve tam metin olarak basılan konuşmalar)

105. Yeni biyolojik ajanların klinikte kullanımı. Coşan F.22. Ulusal İmmünoloji Kongresi, 27-30 Nisan 2013, Çeşme. (The clinical use of new biological agents)

Projects (Projeler)

106. The role of T cell subgroups in the pathogenesis of Behçet's disease (Kocaeli University Scientific Research Unit - Quick Support Project (2012-2013)) (Project manager)
107. Investigation of NK cell and subgroups in the pathogenesis of Behçet's disease (Kocaeli University Scientific Research Unit - Quick Support Project (2012-2013)) (Project manager)
108. Go More-P06129-Rheumatoid Arthritis-Phase IIIb-EudraCT 2009-011137-26 (2009-2011) (Assistant researcher in multicenter Phase IIIb study)
109. The role of endoplasmic reticulum stress in the pathogenesis of ankylosing spondylitis and its relationship with HLA-B*27. (Kocaeli University Scientific Research Unit Project No: 2011-12 (2011-2013)) (Project manager)
110. Investigation of the relationship between HLA-B*51 expression and endoplasmic reticulum stress under basal and stimulated conditions in an HLA-B*5 expressing monocyte cell line. (İstanbul University Scientific Research Projects Unit Project No:5903 (2009-2011)) (Project manager)
111. Investigation of unfolded protein response associated with HLA-B51 expression in the pathogenesis of Behçet's disease. (İstanbul University Scientific Research Projects Unit Project No:574 (2009-2011)) (Assistant Researcher)
112. Investigation of the effect of MEFV gene 3'-UTR region on mRNA regulation. (İstanbul University Scientific Research Projects Unit Project No:2669 (2008-2011)) (Assistant Researcher)
113. Low-dose natural human interferon-alpha lozenges in the treatment of Behçet's syndrome. (2007-2008) (Assistant researcher in multicenter Phase III study)
114. The role of MEFV gene mutations in the pathogenesis of spondyloarthropathies - (İstanbul University Scientific Research Projects Unit Project No: T-527/21102004 (2004-2007)) (Project manager)
115. CAMN107A2109 Oral AMN107 use in adult chronic myeloid leukemia patients in chronic phase, accelerated phase, and blast crisis, who are resistant or intolerant to Imatinib (Glivec). (2006-2008) (Assistant researcher in open-label, multicenter early access study)

Duties in Drug Studies (İlaç Çalışmalarında Yaptığı Görevler)

116. Go More-P06129-Rheumatoid Arthritis-Phase IIIb-EudraCT 2009-011137-26 (2009-2011) (Assistant researcher in multicenter Phase IIIb study)
117. Low-dose natural human interferon-alpha lozenges in the treatment of Behçet's syndrome (2007-2008) (Assistant researcher in multicenter Phase III study)
118. CAMN107A2109 Open-label, multicenter early access study with oral MN107 in adult chronic myeloid leukemia patients in chronic phase, accelerated phase, and blast crisis, who are resistant or intolerant to Imatinib (Glivec) (2006-2008) (Assistant researcher)