Areas of Expertise
- Endoscopy
- Colonoscopy
- Bile Duct Obstructions
- Liver Diseases
- Chronic Viral Hepatitis
- Fatty Liver Disease
- Cancer
- Genetic Cancer
Education And Expertise
- 1995-2001 Ege University Faculty Of Medicine
- 2001-2006 Dokuz Eylül University Faculty Of Medicine Internal Medicine Specialization
- 2008-2011 Göztepe Training And Research Hospital Gastroenterology Minor Field Specialization
- 2014 Ümraniye Training And Research Hospital Gastroenterology Associate Professor
- 2021 University Of Health Sciences Professor
Experience
- 2007-2007 Nusaybin State Hospital Internal Medicine Specialist
- 2011-2014 Ümraniye Training And Research Hospital Gastroenterology Specialist
- 2014-2017 Ümraniye Training And Research Hospital Gastroenterology Associate Professor
- 2017-2021 University Of Health Sciences Gastroenterology Associate Professor
- 2015-2021 Ümraniye Training And Research Hospital Gastroenterology Clinic Chief
- 2021-2022 University Of Health Sciences Internal Medicine And Gastroenterology Professor
- 2015-2022 Istanbul Provincial Health Directorate Genomic Laboratory (GLAB) Coordinator
- 2014-2021 Northern Clinics Of Istanbul Journal Indexed In WoS And Pubmed Founding Editor
- 2021 Member Of The Board Of Directors Of The Turkish Association For The Study Of The Liver
- 2022 Hepatology Bulletin Journal Editor
- 2019 Hepatology Forum Journal Editor
- 2016 World Journal Of Hepatology Journal Editor
Foreign Experience
- Intern Doctor, Regional Infectious Diseases Unit, Western General Hospital, Edinburgh, UK, 1999
- Intern Doctor, Cardiology Unit, North Manchester General Hospital, Manchester, UK, 2000
- Assistant Doctor, Regional Infectious Diseases Unit, Western General Hospital, Edinburgh, UK, 2005
Professional Memberships
- Turkish Society Of Gastroenterology
- Turkish Association For The Study Of The Liver
- European Association For The Study Of Liver
- Asian Pacific Association For The Study Of Liver
- American Association For The Advancement Of Science
Awards
- 2013 “Liver Fibrosis Pathways In Chronic Hepatitis B: A Comparative Proteomic Study” Gilead Fellowship Award
- 2014 “Liver Fibrosis Pathways In Chronic Hepatitis B: A Comparative Proteomic Study” Viral Hepatitis Prevention Association Project Support Award
- 2015 “Investigation Of Damage Pathways In Liver Tissue In Chronic Hepatitis B: A Comparative Proteomic Study” Turkish Society Of Gastroenterology, Best Oral Presentation Third Place Award
- 2014 “The Relationship Between Spontaneous Seroconversion And Toll Like Receptor Gene Polymorphism In Hepatitis B Infection.” Turkish Society Of Gastroenterology Best Poster Second Place Award
- 2016 “Investigations Of The EGF And Its Receptor EGFR Gene Variants In Ulcerative Colitis. XV” Euroasian Congress Of Gastroenterology And Surgery, Best Oral Presentation Third Place Award
Projects Executed And Participated In
- “Establishment Of Early Warning System In Colon And Breast Cancers And Integration Into The Personal Health System E-Nabız Database Project” TÜBİTAK 1003, Project No: 318S127, 2020-2023, Project Manager
- “Biological Pharmaceutical Agent Production Technologies Development Center: GLAB BIOPHARMA “Istanbul Development Agency (İSTKA) Feasibility Support Program 2020 Project No: TR10/19/FZD, Project Executive
- “Turkey Genome Project, Individual And Translational Medicine Applied Project Collaboration” TÜSEB 2019, Project Executive
- “Sequencing Of Sars-Cov-2 Virus Genome And Investigation Of Genetic Changes” TÜSEB 2020, Project No: 2020-CV-01-8686/8789, Project Executive
- “Cancer-Focused Data Analysis, Genomic Analysis, R&D And Genomics Education Capacity Building Project, CANCER ÇAARE” Istanbul Development Agency (İSTKA) Innovative And Creative Istanbul Financial Program 2016, YNY2016/144, Project Executive
- “Advanced Genetic Laboratory Establishment Project For Screening Individual-Specific Familial Cancer Syndromes: GLAB” İSTKA Innovative Istanbul Financial Program 2015, YNK 2015/0085, Project Executive
- “eHealth Innovation In Empowering The Patient” European Commission The EU Framework Programme Horizon 2020 SC1-PM-12-2016 – PCP 724409, 2017-2020, Project Consultant
- “STAMINA - Demonstration Of Intelligent Decision Support For Pandemic Crisis Prediction And Management Within And Across European Borders” European Commission The EU Framework Programme Horizon H2020-SU-SEC-2019 – REA 883441, 2021, Project Researcher
- “Investigation Of The Effects Of Covid-19 Disease On Kidney Tissue And Male Reproductive Health” TÜSEB, 2020-CV-01-8708/8969, 2020, Project Researcher
- “GENFIT-Phase 3 Elafibranor/NASH RESOLVE-IT (GFT505-315-1)” International Multicenter Phase 3 Drug Study Aimed At Improving Liver Fibrosis In Non-Alcoholic Fatty Liver Disease, 2017-2021, Project Researcher
- “EPI-C, Multicenter, Observational Study Evaluating Risk Factors Reported By Hepatitis C Patients Admitted To Hospitals In Different Geographical Regions Of Turkey” 2016, Project Researcher
- “A Multicenter Randomized Double Blind Placebo Controlled Study To Evaluate The Safety And Efficacy Of ABT-494 For Induction And Maintenance Therapy In Subject With Moderately To Severe Active Ulcerative Colitis” Phase 2 Drug Study, 2019, Project Researcher
- “Multicenter, Parallel-Group Randomized Open-Label, Phase II Study Evaluating The Safety And Efficacy Of Combined Hydroxychloroquine Used In Standard Treatment For Covid-19 With Parallel Cofactor Support Combination”, 2020, Project Researcher
- “Multicenter, Parallel-Group, Randomized, Double-Blind, Phase III Study Evaluating The Safety And Efficacy Of Metabolic Cofactor Support Combination With Hydroxychloroquine Or Favipiravir Used In Standard Care For Covid-19 Treatment” 2021, Project Researcher
- “Randomized, Double-Blind, Placebo-Controlled Phase III Clinical Trial To Evaluate The Efficacy And Safety Of Inactivated SARS-CoV-2 Vaccine (Vero Cell)”, 2020, Project Researcher
- “A Phase 2 Open-Label Randomized Efficacy And Safety Study Comparing The Use Of Acalabrutinib With Best Supportive Care Treatment In Hospitalized Patients Diagnosed With COVID-19”, 2020, Project Researcher
- “Randomized, Observer-Blinded Phase III Clinical Trial Evaluating The Efficacy, Immunogenicity And Safety Of Two Doses Of CoronaVac (Sinovac) Vaccine Versus Two Doses Of Inactivated COVID-19 Vaccine (TURKOVAC) In Healthy Volunteers”, 2021, Project Researcher
Articles Published In International Peer-Reviewed Journals
- Tanriover MD., Doğanay L, Akova M., Güner HR, Azap A, Akhan S., Köse Ş, Erdinç FŞ, Akalın EH., Tabak EF, Pullukçu H., Batum Ö., Yavuz S., Turhan Ö., Yıldırmak MT., Köksal İ., Taşova Y., Korten V., Yılmaz G., Çelen MK., Altın S., Çelik İ., Bayındır Y., Karaoğlan İ., Yılmaz A., Özkul A., Gür H., Unal S., And The CoronaVac Study Group. Efficacy And Safety Of An Inactivated Whole Virion SARS-CoV-2 Vaccine, CoronaVac: Interim Results Of A Randomised, Double-Blind, Placebo-Controlled Phase III Clinical Trial In Turkey, Lancet 2021;398(10296):213-22. Doi: 10.1016/S0140-6736(21)01429-X
- Tanriover MD., Doğanay L, Serhat Ünal, Akova M. Coronavac Efficacy Data From Turkey. Lancet 2021; 398(10314):1874. Doi: 0.1016/S0140-6736(21)02286-8
- Ozfiliz Kilbas P., Can ND, Kizilboga T., Ezberci F., Doganay L., Arisan DE, Dinler Doganay G. CRISPR/Cas9-Mediated Bag-1 Knockout Increased Mesenchymal Characteristics Of MCF-7 Cells Via Akt Hyperactivation-Mediated Actin Cytoskeleton Remodeling. Plos One. Accepted, On Publication
- Zhong W, Altay O, Arif M, Edfors F, Doganay L, Mardinoglu A, Uhlen M, Fagerberg L. Next Generation Plasma Proteome Profiling Of COVID-19 Patients With Mild To Moderate Symptoms. EBioMedicine. 2021 Doi: 10.1016/J.Ebiom.2021.103723. Epub Ahead Of Print. PMID: 34844191; PMCID: PMC8626206
- Akgun-Dogan O, Ağaoğlu NB, Demirkol YK, Doğanay L, Ergül Y, Karacan M. Mutational Spectrum Of Congenital Long QT Syndrome In Turkey; Identification Of Twelve Novel Mutations Across KCNQ1, KCNH2, SCN5A, KCNJ2, CACNA1C, CALM1. J Cardiovasc Electrophysiol. 2021 Dec 3. Doi: 10.1111/Jce.15306. Epub Ahead Of Print. PMID: 34860437
- Altay O., Yang H., Aydin M., Alkurt G., Altunal N., Kim W., Akyol D., Arif M., Zhang C., Dinler-Doganay G., Turkez H., Shoaie S., Nielsen J., Boren J., Doganay L., Uhlen M., Mardinoglu A. Combined Metabolic Coactivators Accelerates Recovery In Mild To-Moderate COVID-19, Advanced Science. Doi.Org/10.1002/Advs.202101222
- Agaoglu NB, Doganay L. Concurrent Pathogenic Variations In Patients With Hereditary Cancer Syndromes, European Journal Of Medical Genetics, 2021;64(12);104366. Doi: 10.1016/J.Ejmg.2021.104366
- Can N. D., Basturk E., Kizilboga T., Akcay I. M., Dingiloglu B., Acar S., Elibeyli E., Muratcıoglu S., Januzzi A., Gursoy A., Keskin O., Doganay H. L., Karademir-Yilmaz B., Dinler-Doganay G. Interactome Analysis Of Bag-1 Isoforms Reveals Novel Interaction Partners In ER- Associated Degradation. Plos One 2021;16(8):E0256640. Doi: 10.1371/Journal.Pone.0256640
- Gokcen P., Guzelbulut F., Adalı G., Degirmenci AG, Ozturk O., Bahadır O., Kanatsiz E., Kiyak M., Ozdil K., Doganay L. Validation Of The PAGE-B Score To Predict Hepatocellular Carcinoma Risk In Caucasian Chronic Hepatitis B Patients On Treatment World Journal Of Gastroenterology, Accepted, On Publication
- Alm E, Broberg EK, Connor T, Hodcroft EB, Komissarov AB, Maurer-Stroh S, Melidou A, Neher RA, O'Toole Á, Pereyaslov D; WHO European Region Sequencing Laboratories And GISAID EpiCoV Group; WHO European Region Sequencing Laboratories And GISAID EpiCoV Group*. Geographical And Temporal Distribution Of SARS-CoV-2 Clades In The WHO European Region, January To June 2020. Euro Surveill. 2020 Aug;25(32):2001410. Doi: 10.2807/1560-7917.ES.2020.25.32.2001410
- Karacan I., Akgun T. K., Agaoglu N. B., Zolfagharian P., Aydin M., Alkurt G., Yildiz J., Kose B., Can N.D., Ozel A.S., Altunal N., Irvem A., Demirkol Y., Akgun-Dogan O., Doganay L, Dinler-Doganay G. Genomic Diversity Of The SARS-CoV-2 In Turkey And The Impact Of Virus Genome Mutations On Clinical Outcomes. (Under Review)
- Doganay L, Agaoglu NB, Irvem A, Alkurt G, Yildiz J, Kose B, Demirkol YK, Dogan OA, Doganay GD. Responding To COVID-19 In Istanbul: Perspective From Genomic Laboratory. North Clin Istanb. 2020;7(3):311-312. Doi: 10.14744/Nci.2020.30075
- Karacan I, Akgun TK, Agaoglu NB, Irvem A, Alkurt G, Yildiz J, Kose B, Ozel AS, Altunal LN, Can ND, Demirkol YK, Aydin M, Dogan OA, Doganay L, Doganay GD. The Origin Of SARS-CoV-2 In Istanbul: Sequencing Findings From The Epicenter Of The Pandemic In Turkey. North Clin Istanb. 2020;7(3):203-209. Doi: 10.14744/Nci.2020.90532
- Alkurt G., Ahmet M., Aydın Z., Tatlı O., Agaoglu NB., Irvem A., Aydın M., Karaali R., Günes, M., Yeşilyurt B., Türkez H., Mardinoglu A., Doganay M., Basinoglu F., Seyahi N., Dinler Doganay G., Doganay L. Seroprevalence Of Coronavirus Disease 2019 (COVID-19) Among Health Care Workers From Three Pandemic Hospitals Of Turkey, Plos One 2021:16(3): E0247865, Doi: 10.1371/Journal.Pone.0247865
- Dogan O. A., Kose B., Agaoglu N. B., Yildiz J., Alkurt G., Demirkol Y. K., Irvem A., Dinler- Doganay G., L Doganay. Does Sampling Saliva Increase Detection Of SARS-CoV-2 By RT-PCR? Comparing Saliva With Oro-Nasopharyngeal Swabs. J Virologic Methods 2021(290): 114049. Doi: 10.1016/J.Jviromet.2020.114049
- Agaoglu N. B., Yıldız J., Dogan O. A., Alkurt G., Kose B., Demirkol Y., Irvem A., Doganay L., Dinler-Doganay G. COVID-19 PCR Test Performance For Samples Stored At Ambient Temperature, J Virologic Methods Accepted On Publication
- Temiz MZ, Dincer MM, Hacibey I, Yazar RO, Celik C, Kucuk SH, Alkurt G, Doganay L, Yuruk E, Muslumanoglu AY. Investigation Of SARS-CoV-2 In Semen Samples And The Effects Of COVID-19 On Male Sexual Health By Using Semen Analysis And Serum Male Hormone Profile: A Cross-Sectional, Pilot Study. Andrologia. 2020(26): E13912. Doi: 10.1111/And.13912
- Akcay IM, Celik E, Agaoglu NB, Alkurt G, Kizilboga Akgun T, Yildiz J, Enc F, Kir G, Canbek S, Kilic A, Zemheri E, Ezberci F, Ozcelik M, Dinler Doganay G, Doganay L. Germline Pathogenic Variant Spectrum In 25 Cancer Susceptibility Genes In Turkish Breast And Colorectal Cancer Patients And Elderly Controls. Int J Cancer. 2021; 148(2): 285295. Doi: 10.1002/Ijc.33199
- Sayar S., Gökçen P., Aykut H., Adalı G., Doğanay HL, Özdil K. Can Simple Non-Invasive Fibrosis Models Determine Prognostic Indicators (Fibrosis And Treatment Response) Of Primary Biliary Cholangitis? Med Bull Sisli Etfal Hosp 2021;55(3):412–418. Doi: 10.14744/Semb.2021.95825
- Sayar S, Ayranci G, Kürbüz K, Ak Ç, Tarikçi Kiliç E, Kahraman R, Atalay R, Öztürk O, Çalişkan Z, Adali G, Doganay L, Özdil K. High Frequency Of Gastric Cancer Precursor Lesions In Patients With Gastric Xanthelasma: A Prospective Case-Control Study. Eur J Gastroenterol Hepatol. 2020;32(9):1130-1134. Doi:10.1097/MEG.0000000000001795
- Sözeri B, Demir F, Sönmez HE, Karadağ ŞG, Demirkol YK, Doğan ÖA, Doğanay HL, Ayaz NA. Comparison Of The Clinical Diagnostic Criteria And The Results Of The Next Generation Sequence Gene Panel In Patients With Monogenic Systemic Autoinflammatory Diseases. Clin Rheumatol. 2021;40(6):2327-37. Doi: 10.1007/S10067-020-05492-8
- Demir F, Bolac GL, Merter T, Canbek S, Dogan OA, Demirkol YK, Yildiz J, Doganay HL, Sozeri B. The Musculoskeletal System Manifestations In Children With Familial Mediterranean Fever. North Clin Istanb. 2020 4;7(5):438-442. Doi: 10.14744/Nci.2020.96636
- Sayar S, Kürbüz K, Kahraman R, Öztürk O, Çalışkan Z, Doğanay HL, Özdil K. Risk Of Hepatitis B Reactivation During Anti-TNF Therapy; Evaluation Of Patients With Past Hepatitis B Infection. Turk J Gastroenterol. 2020;31(7):522-528. Doi: 10.5152/Tjg.2020.19295
- Demir F, Doğan ÖA, Demirkol YK, Tekkuş KE, Canbek S, Karadağ ŞG, Sönmez HE, Ayaz NA, Doğanay HL, Sözeri B. Genetic Panel Screening In Patients With Clinically Unclassified Systemic Autoinflammatory Diseases. Clin Rheumatol. 2020;39(12):3733-3745. Doi: 10.1007/S10067-020-05108-1
- Sayar S, Kurbuz K, Kahraman R, Caliskan Z, Atalay R, Ozturk O, Doganay HL, Ozdil K. A Practical Marker To Determining Acute Severe Ulcerative Colitis: CRP/Albumin Ratio. North Clin Istanb. 2019:25;7(1):49-55. Doi: 10.14744/Nci.2018.78800
- Bulur A, Ozdil K, Doganay L, Ozturk O, Kahraman R, Demirdag H, Caliskan Z, Mutlu Bilgic N, Kanat E, Serap Erden A, Mehmet Sokmen H. Polypoid Lesions Detected In The Upper Gastrointestinal Endoscopy: A Retrospective Analysis In 19560 Patients, A Single-Center Study Of A 5-Year Experience In Turkey. North Clin Istanb. 2020 Nov 27;8(2):178-185. Doi: 10.14744/Nci.2020.16779
- Sozeri B, Ercan G, Dogan OA, Yıldız J, Demir F, Doğanay L. The Same Mutation In A Family With Adenosine Deaminase 2 Deficiency. Rheumatol Int. 2021;41(1). Doi: 10.1007/S00296-019-04444-Z
- Geyik G, Sahin A, Pekcioglu Y, Okuroglu N, Doganay L, Ozdil K. Is NRS-2002 A Reliable Tool In The Nutritional Assessment Of Cirrhosis: A Comparative Study. Acta Medica Mediterranea. 2021;37(1):43–50
- Güzelbulut F, Gökçen P, Can G, Adalı G, Değirmenci Saltürk AG, Bahadır Ö, Ozdil K., Doganay L. Validation Of The HCC-RESCUE Score To Predict Hepatocellular Carcinoma Risk In Caucasian Chronic Hepatitis B Patients Under Entecavir Or Tenofovir Therapy. Journal Of Viral Hepatitis. 2021;28(5)
- Gokcen P, Cakmak E, Adali G, Dogan HO, Yildiz SN, Ozturk O, Doganay L, Ozdil K. Liver Fatty Acid Binding Protein: Is It An Early Diagnostic And Prognostic Marker In Liver Damage? Medical Science And Discovery. 2021;8(4)
- Sayar S, Atalay R, Çakmak Ş, Ayrancı G, Kürbüz K, Kahraman R, Caliskan Z., Ozturk O., Demirdağ H., Adali G., Ozdil K., Doganay L. Diagnostic Performance Of Non-Invasive Fibrosis Indexes In Hepatitis B Related Fibrosis. Viral Hepatitis Journal. 2020;26(2)
- Değertekin B, Demir M, Akarca US, Kani HT, Üçbilek E, Yıldırım E, Güzelbulut F, Balkan A, Vatansever S, Danış N, Demircan M, Soylu A, Yaras S, Kartal A, Kefeli A, Gündüz F, Yalçın K, Erarslan E, Aladağ M, Harputluoğlu M, Özakyol A, Temel T, Akarsu M, Sümer H, Akın M, Albayrak B, Sen İ, Alkım H, Uyanıkoğlu A, Irak K, Öztaşkın S, Uğurlu ÇB, Güneş Ş, Gürel S, Nuriyev K, İnci İ, Kaçar S, Dinçer D, Doğanay L, Göktürk HS, Mert A, Coşar AM, Dursun H, Atalay R, Akbulut S, Balkan Y, Koklu H, Şimşek H, Özdoğan O, Çoban M. Real-World Efficacy And Safety Of Ledipasvir + Sofosbuvir And Ombitasvir/Paritaprevir/Ritonavir ± Dasabuvir Combination Therapies For Chronic Hepatitis C: A Turkish Experience. Turk J Gastroenterol. 2020 Dec;31(12):883-893. Doi: 10.5152/Tjg.2020.20696
- Çalışkan Z, Demircioglu K, Sayar S., Kahraman R., Caklili Ö, Özcan FB, Köstek Ö, Baycan OF, Doganay L, Caliskan M. Lipid Profile, Atherogenic Indices, And Their Relationship With Epicardial Fat Thickness And Carotid Intima–Media Thickness In Celiac Disease. North Clin Istanb. 2019; 6(3): 242-247. Doi: 10.14744/Nci.2019.54936
- Akcay IM, Katrinli S, Ozdil K, Doganay GD, Doganay L. Host Genetic Factors Affecting Hepatitis B Infection Outcomes: Insights From Genome-Wide Association Studies. World J Gastroenterol. 2018;24(30):3347-3360. Doi: 10.3748/Wjg.V24.I30.3347
- Celik E, Ermis Tekkus K, Akcay IM, Alkurt Sal G, Ezberci F, Dinler Doganay G, Doganay L. Identification Of A BRCA2 Mutation In A Turkish Family With Early-Onset Breast Cancer. Clin Case Rep. 2018;6(9):1751-1755. Doi: 10.1002/Ccr3.1625
- Doganay L. Hepatocellular Cancer: Is Recurrence Inevitable? J Gastrointest Cancer. 2017. Doi: 10.1007/S12029-017-9967-0
- Kilic E, Doganay L, Ozdil K. Endoscopic Retrograde Cholangiopancreaticography In Elderly Patients: A Reliable Alternative In Sepsis. North Clin Istanb. 2018; 5(2): 169-170. Doi: 10.14744/Nci.2018.92679
- Katrinli S, Nigdelioglu A, Ozdil K, Dinler-Doganay G, Doganay L. The Association Of Variations In TLR Genes And Spontaneous Immune Control Of Hepatitis B Virus. Clin Res Hepatol Gastroenterol. 2018;42(2):139-144. Doi: 10.1016/J.Clinre.2017.10.002
- Ozdil K, Caliskan Z, Keles N, Ozturk O, Tekin AS, Kahraman R, Doganay L, Demircioglu K, Yilmaz Y, Caliskan M. Echocardiographic Epicardial Fat Thickness Measurement: A New Screening Test For Subclinic Atherosclerosis In Patients With Inflammatory Bowel Diseases. North Clin Istanb. 2017;4(1):4-12. Doi: 10.14744/Nci.2017.74508
- Katrinli S, Gurbet-Erkut N, Ozdil K, Yilmaz-Enc F, Ozturk O, Kahraman R, Tuncer I, Dinler-Doganay G, Doganay L. HLA DPB1 15:01 Allele Predicts Spontaneus Hepatitis B Surface Antigen Seroconversion. Acta Gastro-Enterologica Belgica. 2017;80(3):351
- Katrinli S, Ozdil K, Sahin A, Kir G, Baykal AT, Akgun E, Sarac OS, Sokmen M, Dinler Doganay G, Doganay L. Proteomic Profiling Of HBV Infected Liver Biopsies With Different Fibrotic Stages. Proteome Science 2017;15:7. Doi: 10.1186/S12953-017-0114-4
- Ozturk O, Doganay L, Colak Y, Yilmaz Enc F, Ulasoglu C, Ozdil K, Tuncer I. Therapeutic Success With Bismuth-Containing Sequential And Quadruple Regimens In Helicobacter Pylori Eradication. Arab Journal Of Gastroenterology, 2017. Doi: 10.1016/J.Ajg.2017.05.002
- Doganay L, Ozdil K, Memisoglu K, Katrinli S, Karakoc E, Nikerel E, Doganay G. Integrating Personalized Genomics To Turkish Health Care System: A Cancer Oriented Pilot Activity Of Istanbul Northern Anatolian Public Hospitals With GLAB. North Clin Istanb. 2017; 4(1):1-3. Doi: 10.14744/Nci.2017.38980
- Katrinli S, Yilmaz Enc F, Ozdil K, Ozturk O, Tuncer I, Dinler Doganay G, Doganay L. Effect Of HLA-DPA1 Alleles On Chronic Hepatitis B Prognosis And Treatment Response. North Clin Istanb 2016;3(3):168-174. Doi: 10.14744/Nci.2016.27870
- Ozdil K., O. Ozturk, E.S. Calik, E.S. Akbas, E. Kanat, Z. Caliskan, H. Demirdag, R. Kahraman, A. Bulur, N.M. Bilgic, Doganay L., H.M. Sokmen. Relationship Between Size Of Varices And Platelet Count/Spleen Size Ratio In Cirrhotic Patients. North Clin Istanb. 2016;3(1):46-52. Doi: 10.14744/Nci.2016.60362
- Ozturk O, Colak Y, Senates E, Yilmaz Y, Ulasoglu C, Doganay L, Ozkanli S, Oltulu YM, Coskunpinar E, Tuncer I. Increased Serum Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels In Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. World J Gastroenterol. 2015;21(26):8096-102. Doi:10.3748/Wjg.V21.I26.8096
- Gonen C, Gunduz F, Doganay L, Enc FY, Yegin EG, Ahishali E, Erdem E, Sokmen M, Tuncer I, Ozdogan O. High Treatment Modification Rates With Lamivudine Therapy In HBV-Infected Patients With Low Baseline Viremia And Early Virological Response: A Multicenter Study. J Dig Dis. 2015 May;16(5):286-92. Doi: 10.1111/1751-2980.12237
- Doganay L, Katrinli S, Colak Y, Senates E, Zemheri E, Ozturk O, Enc FY, Tuncer I, Doganay GD. HLA DQB1 Alleles Are Related With Nonalcoholic Fatty Liver Disease. Mol Biol Rep. 2014;41(12):7937-43. Doi: 10.1007/S11033-014-3688-2
- L. Doganay, A. Fejzullahu, S. Katrinli, F. Yilmaz Enc, O. Ozturk, Y. Colak, C. Ulasoglu, I. Tuncer, G. Dinler Doganay. Association Of Human Leukocyte Antigen DQB1 And DRB1 Alleles With Chronic Hepatitis B. World J Gastroenterol. 2014 Jul 7;20(25):8179-86. Doi: 10.3748/Wjg.V20.I25.8179
- L. Doganay, I. Tuncer, S. Katrinli, F.Y. Enc, O. Ozturk, Y. Colak, C. Ulasoglu, G. Dinler. The Effect Of HLA-DQB1 Alleles On Virologic Breakthroughs During Chronic Hepatitis B Treatment With Genetically Low Barrier Drugs. Clinics And Research In Hepatology And Gastroenterology. 2013 Sep;37(4):359-64. Doi: 10.1016/J.Clinre.2012.10.013
- T. Calhan, R. Kahraman, A. Sahin, E. Senates, H.L. Doganay, E. Kanat, K. Ozdil, H.M. Sokmen. Efficacy Of Two Levofloxacin-Containing Second-Line Therapies For Helicobacter Pylori: A Pilot Study. Helicobacter. 2013 Oct;18(5): 378-83. Doi: 10.1111/Hel.12056
- Y. Yilmaz, O. Ozturk, Y.O. Alahdab, E. Senates, Y. Colak, H.L. Doganay, E. Coskunpinar, Y.M. Oltulu, F. Eren, O. Atug, I. Tuncer, N. Imeryuz. Serum Osteopontin Levels As A Predictor Of Portal Inflammation In Patients With Nonalcoholic Fatty Liver Disease. Digestive And Liver Disease. 2013 Jan;45(1):58-62. Doi: 10.1016/J.Dld.2012.08.017
- L. Doganay, K. Ozdil, M. Sokmen. Last Blood Check Before Passing: Does Alcohol Prevent Fibrosis? The American Journal Of Gastroenterology. 2013 Jun;108(6):1010. Doi: 10.1038/Ajg.2013.74
- Y. Colak, E. Senates, A. Yesil, Y. Yilmaz, O. Ozturk, L. Doganay, E. Coskunpinar, O.T. Kahraman, B. Mesci, C. Ulasoglu, I. Tuncer. Assessment Of Endothelial Function In Patients With Nonalcoholic Fatty Liver Disease. Endocrine. 2013 Feb;43(1):100-7. Doi: 10.1007/S12020-012-9712-1
- C. Ulasoglu, B. Isbilen, L. Doganay, F. Ozen, S. Kiziltas, I. Tuncer. Effect Of Helicobacter Pylori Eradication On Serum Ghrelin And Obestatin Levels. World Journal Of Gastroenterology. 2013 Apr 21;19(15):2388-94. Doi: 10.3748/Wjg.V19.I15.2388
- Y. Colak, I. Tuncer, E. Senates, O. Ozturk, L. Doganay, Y. Yilmaz. Nonalcoholic Fatty Liver Disease: A Nutritional Approach. Metabolic Syndrome And Related Disorders. 2012 Jun;10(3):161-6. Doi: 10.1089/Met.2011.0145
- Y. Colak, E. Senates, E. Coskunpinar, Y.M. Oltulu, E. Zemheri, O. Ozturk, L. Doganay, B. Mesci, Y. Yilmaz, F.Y. Enc, S. Kiziltas, C. Ulasoglu, I. Tuncer. Concentrations Of Connective Tissue Growth Factor In Patients With Nonalcoholic Fatty Liver Disease: Association With Liver Fibrosis. Disease Markers. 2012;33(2):77-83. Doi: 10.3233/Dma2012-0907
- Tuncer, Y. Colak, R. Yigitbasi, E. Zemheri, T. Ayaz, E. Yorulmaz, L. Doganay, O. Ozturk, G. Adali. Mesenteric Inflammatory Veno-Occlusive Disease: An Unusual Cause Of Colonic Ischemia. The Turkish Journal Of Gastroenterology. 2011 Oct;22(5):561-2. Doi: 10.4318/Tjg.2011.0262
- Y. Colak, C.Y. Karabay, I. Tuncer, G. Kocabay, A. Kalayci, E. Senates, O. Ozturk, H.L. Doganay, F.Y. Enc, C. Ulasoglu, S. Kiziltas. Relation Of Epicardial Adipose Tissue And Carotid Intima-Media Thickness In Patients With Nonalcoholic Fatty Liver Disease. European Journal Of Gastroenterology & Hepatology. 2012 Jun;24(6):613-8. Doi: 10.1097/MEG.0b013e3283513f19
- L. Doganay, S. Kiziltas, Y. Colak, M. Gulluoglu, I. Tuncer. Is The Lymphoma Risk Reduced In Viral Hepatitis? A Cirrhotic Patient With Triple Malignancies. The American Journal Of Gastroenterology. 2011 Sep;106(9):1719-20; Author Reply 20. Doi: 10.1038/Ajg.2011.214
- Y. Colak, O. Ozturk, E. Senates, I. Tuncer, E. Yorulmaz, G. Adali, L. Doganay, F.Y. Enc. SIRT1 As A Potential Therapeutic Target For Treatment Of Nonalcoholic Fatty Liver Disease. Medical Science Monitor. 2011 May;17(5):HY5-9. Doi: 10.12659/Msm.881749
- Tuncer, L. Doganay, O. Ozturk. Instant Control Of Fundal Variceal Bleeding With A Folkloric Medicinal Plant Extract: Ankaferd Blood Stopper. Gastrointestinal Endoscopy. 2010 Apr;71(4):873-5. Doi: 10.1016/J.Gie.2009.08.021
- Y. Colak, E. Senates, O. Ozturk, H.L. Doganay, E. Coskunpinar, Y.M. Oltulu, A. Eren, O. Sahin, S. Ozkanli, F.Y. Enc, C. Ulasoglu, I. Tuncer. Association Of Serum Lipoprotein Associated Phospholipase A2 Level With Nonalcoholic Fatty Liver Disease. Metabolic Syndrome And Related Disorders. 2012 Apr;10(2):103-9. Doi: 10.1089/Met.2011.0111
- H.A. Bodur, E. Saygili, S. Saygili, L.H. Doganay, S. Yesil. Continuous Infusion Of Subcutaneous Compared To Intravenous Insulin For Tight Glycaemic Control In Medical Intensive Care Unit Patients. Anaesthesia And Intensive Care. 2008 Jul;36(4):520-7. Doi: 10.1177/0310057X0803600421
- L. Doganay, P.D. Welsby. Anthrax: A Disease In Waiting? Postgraduate Medical Journal. 2006 Nov;82(973):754-6. Doi: 10.1136/Pgmj.2005.044487
- L. Doganay, B. Akinci, N. Pekel, I. Simsek, H. Akpinar. Mesalazine-Induced Myopericarditis In A Patient With Ulcerative Colitis. International Journal Of Colorectal Disease. 2006 Mar;21(2):199-200. Doi: 10.1007/S00384-004-0706-1
Resume
Education And Expertise
- 1995-2001 Ege University Faculty Of Medicine
- 2001-2006 Dokuz Eylül University Faculty Of Medicine Internal Medicine Specialization
- 2008-2011 Göztepe Training And Research Hospital Gastroenterology Minor Field Specialization
- 2014 Ümraniye Training And Research Hospital Gastroenterology Associate Professor
- 2021 University Of Health Sciences Professor
Experience
- 2007-2007 Nusaybin State Hospital Internal Medicine Specialist
- 2011-2014 Ümraniye Training And Research Hospital Gastroenterology Specialist
- 2014-2017 Ümraniye Training And Research Hospital Gastroenterology Associate Professor
- 2017-2021 University Of Health Sciences Gastroenterology Associate Professor
- 2015-2021 Ümraniye Training And Research Hospital Gastroenterology Clinic Chief
- 2021-2022 University Of Health Sciences Internal Medicine And Gastroenterology Professor
- 2015-2022 Istanbul Provincial Health Directorate Genomic Laboratory (GLAB) Coordinator
- 2014-2021 Northern Clinics Of Istanbul Journal Indexed In WoS And Pubmed Founding Editor
- 2021 Member Of The Board Of Directors Of The Turkish Association For The Study Of The Liver
- 2022 Hepatology Bulletin Journal Editor
- 2019 Hepatology Forum Journal Editor
- 2016 World Journal Of Hepatology Journal Editor
Foreign Experience
- Intern Doctor, Regional Infectious Diseases Unit, Western General Hospital, Edinburgh, UK, 1999
- Intern Doctor, Cardiology Unit, North Manchester General Hospital, Manchester, UK, 2000
- Assistant Doctor, Regional Infectious Diseases Unit, Western General Hospital, Edinburgh, UK, 2005
Professional Memberships
- Turkish Society Of Gastroenterology
- Turkish Association For The Study Of The Liver
- European Association For The Study Of Liver
- Asian Pacific Association For The Study Of Liver
- American Association For The Advancement Of Science
Awards
- 2013 “Liver Fibrosis Pathways In Chronic Hepatitis B: A Comparative Proteomic Study” Gilead Fellowship Award
- 2014 “Liver Fibrosis Pathways In Chronic Hepatitis B: A Comparative Proteomic Study” Viral Hepatitis Prevention Association Project Support Award
- 2015 “Investigation Of Damage Pathways In Liver Tissue In Chronic Hepatitis B: A Comparative Proteomic Study” Turkish Society Of Gastroenterology, Best Oral Presentation Third Place Award
- 2014 “The Relationship Between Spontaneous Seroconversion And Toll Like Receptor Gene Polymorphism In Hepatitis B Infection.” Turkish Society Of Gastroenterology Best Poster Second Place Award
- 2016 “Investigations Of The EGF And Its Receptor EGFR Gene Variants In Ulcerative Colitis. XV” Euroasian Congress Of Gastroenterology And Surgery, Best Oral Presentation Third Place Award
Publications
Projects Executed And Participated In
- “Establishment Of Early Warning System In Colon And Breast Cancers And Integration Into The Personal Health System E-Nabız Database Project” TÜBİTAK 1003, Project No: 318S127, 2020-2023, Project Manager
- “Biological Pharmaceutical Agent Production Technologies Development Center: GLAB BIOPHARMA “Istanbul Development Agency (İSTKA) Feasibility Support Program 2020 Project No: TR10/19/FZD, Project Executive
- “Turkey Genome Project, Individual And Translational Medicine Applied Project Collaboration” TÜSEB 2019, Project Executive
- “Sequencing Of Sars-Cov-2 Virus Genome And Investigation Of Genetic Changes” TÜSEB 2020, Project No: 2020-CV-01-8686/8789, Project Executive
- “Cancer-Focused Data Analysis, Genomic Analysis, R&D And Genomics Education Capacity Building Project, CANCER ÇAARE” Istanbul Development Agency (İSTKA) Innovative And Creative Istanbul Financial Program 2016, YNY2016/144, Project Executive
- “Advanced Genetic Laboratory Establishment Project For Screening Individual-Specific Familial Cancer Syndromes: GLAB” İSTKA Innovative Istanbul Financial Program 2015, YNK 2015/0085, Project Executive
- “eHealth Innovation In Empowering The Patient” European Commission The EU Framework Programme Horizon 2020 SC1-PM-12-2016 – PCP 724409, 2017-2020, Project Consultant
- “STAMINA - Demonstration Of Intelligent Decision Support For Pandemic Crisis Prediction And Management Within And Across European Borders” European Commission The EU Framework Programme Horizon H2020-SU-SEC-2019 – REA 883441, 2021, Project Researcher
- “Investigation Of The Effects Of Covid-19 Disease On Kidney Tissue And Male Reproductive Health” TÜSEB, 2020-CV-01-8708/8969, 2020, Project Researcher
- “GENFIT-Phase 3 Elafibranor/NASH RESOLVE-IT (GFT505-315-1)” International Multicenter Phase 3 Drug Study Aimed At Improving Liver Fibrosis In Non-Alcoholic Fatty Liver Disease, 2017-2021, Project Researcher
- “EPI-C, Multicenter, Observational Study Evaluating Risk Factors Reported By Hepatitis C Patients Admitted To Hospitals In Different Geographical Regions Of Turkey” 2016, Project Researcher
- “A Multicenter Randomized Double Blind Placebo Controlled Study To Evaluate The Safety And Efficacy Of ABT-494 For Induction And Maintenance Therapy In Subject With Moderately To Severe Active Ulcerative Colitis” Phase 2 Drug Study, 2019, Project Researcher
- “Multicenter, Parallel-Group Randomized Open-Label, Phase II Study Evaluating The Safety And Efficacy Of Combined Hydroxychloroquine Used In Standard Treatment For Covid-19 With Parallel Cofactor Support Combination”, 2020, Project Researcher
- “Multicenter, Parallel-Group, Randomized, Double-Blind, Phase III Study Evaluating The Safety And Efficacy Of Metabolic Cofactor Support Combination With Hydroxychloroquine Or Favipiravir Used In Standard Care For Covid-19 Treatment” 2021, Project Researcher
- “Randomized, Double-Blind, Placebo-Controlled Phase III Clinical Trial To Evaluate The Efficacy And Safety Of Inactivated SARS-CoV-2 Vaccine (Vero Cell)”, 2020, Project Researcher
- “A Phase 2 Open-Label Randomized Efficacy And Safety Study Comparing The Use Of Acalabrutinib With Best Supportive Care Treatment In Hospitalized Patients Diagnosed With COVID-19”, 2020, Project Researcher
- “Randomized, Observer-Blinded Phase III Clinical Trial Evaluating The Efficacy, Immunogenicity And Safety Of Two Doses Of CoronaVac (Sinovac) Vaccine Versus Two Doses Of Inactivated COVID-19 Vaccine (TURKOVAC) In Healthy Volunteers”, 2021, Project Researcher
Articles Published In International Peer-Reviewed Journals
- Tanriover MD., Doğanay L, Akova M., Güner HR, Azap A, Akhan S., Köse Ş, Erdinç FŞ, Akalın EH., Tabak EF, Pullukçu H., Batum Ö., Yavuz S., Turhan Ö., Yıldırmak MT., Köksal İ., Taşova Y., Korten V., Yılmaz G., Çelen MK., Altın S., Çelik İ., Bayındır Y., Karaoğlan İ., Yılmaz A., Özkul A., Gür H., Unal S., And The CoronaVac Study Group. Efficacy And Safety Of An Inactivated Whole Virion SARS-CoV-2 Vaccine, CoronaVac: Interim Results Of A Randomised, Double-Blind, Placebo-Controlled Phase III Clinical Trial In Turkey, Lancet 2021;398(10296):213-22. Doi: 10.1016/S0140-6736(21)01429-X
- Tanriover MD., Doğanay L, Serhat Ünal, Akova M. Coronavac Efficacy Data From Turkey. Lancet 2021; 398(10314):1874. Doi: 0.1016/S0140-6736(21)02286-8
- Ozfiliz Kilbas P., Can ND, Kizilboga T., Ezberci F., Doganay L., Arisan DE, Dinler Doganay G. CRISPR/Cas9-Mediated Bag-1 Knockout Increased Mesenchymal Characteristics Of MCF-7 Cells Via Akt Hyperactivation-Mediated Actin Cytoskeleton Remodeling. Plos One. Accepted, On Publication
- Zhong W, Altay O, Arif M, Edfors F, Doganay L, Mardinoglu A, Uhlen M, Fagerberg L. Next Generation Plasma Proteome Profiling Of COVID-19 Patients With Mild To Moderate Symptoms. EBioMedicine. 2021 Doi: 10.1016/J.Ebiom.2021.103723. Epub Ahead Of Print. PMID: 34844191; PMCID: PMC8626206
- Akgun-Dogan O, Ağaoğlu NB, Demirkol YK, Doğanay L, Ergül Y, Karacan M. Mutational Spectrum Of Congenital Long QT Syndrome In Turkey; Identification Of Twelve Novel Mutations Across KCNQ1, KCNH2, SCN5A, KCNJ2, CACNA1C, CALM1. J Cardiovasc Electrophysiol. 2021 Dec 3. Doi: 10.1111/Jce.15306. Epub Ahead Of Print. PMID: 34860437
- Altay O., Yang H., Aydin M., Alkurt G., Altunal N., Kim W., Akyol D., Arif M., Zhang C., Dinler-Doganay G., Turkez H., Shoaie S., Nielsen J., Boren J., Doganay L., Uhlen M., Mardinoglu A. Combined Metabolic Coactivators Accelerates Recovery In Mild To-Moderate COVID-19, Advanced Science. Doi.Org/10.1002/Advs.202101222
- Agaoglu NB, Doganay L. Concurrent Pathogenic Variations In Patients With Hereditary Cancer Syndromes, European Journal Of Medical Genetics, 2021;64(12);104366. Doi: 10.1016/J.Ejmg.2021.104366
- Can N. D., Basturk E., Kizilboga T., Akcay I. M., Dingiloglu B., Acar S., Elibeyli E., Muratcıoglu S., Januzzi A., Gursoy A., Keskin O., Doganay H. L., Karademir-Yilmaz B., Dinler-Doganay G. Interactome Analysis Of Bag-1 Isoforms Reveals Novel Interaction Partners In ER- Associated Degradation. Plos One 2021;16(8):E0256640. Doi: 10.1371/Journal.Pone.0256640
- Gokcen P., Guzelbulut F., Adalı G., Degirmenci AG, Ozturk O., Bahadır O., Kanatsiz E., Kiyak M., Ozdil K., Doganay L. Validation Of The PAGE-B Score To Predict Hepatocellular Carcinoma Risk In Caucasian Chronic Hepatitis B Patients On Treatment World Journal Of Gastroenterology, Accepted, On Publication
- Alm E, Broberg EK, Connor T, Hodcroft EB, Komissarov AB, Maurer-Stroh S, Melidou A, Neher RA, O'Toole Á, Pereyaslov D; WHO European Region Sequencing Laboratories And GISAID EpiCoV Group; WHO European Region Sequencing Laboratories And GISAID EpiCoV Group*. Geographical And Temporal Distribution Of SARS-CoV-2 Clades In The WHO European Region, January To June 2020. Euro Surveill. 2020 Aug;25(32):2001410. Doi: 10.2807/1560-7917.ES.2020.25.32.2001410
- Karacan I., Akgun T. K., Agaoglu N. B., Zolfagharian P., Aydin M., Alkurt G., Yildiz J., Kose B., Can N.D., Ozel A.S., Altunal N., Irvem A., Demirkol Y., Akgun-Dogan O., Doganay L, Dinler-Doganay G. Genomic Diversity Of The SARS-CoV-2 In Turkey And The Impact Of Virus Genome Mutations On Clinical Outcomes. (Under Review)
- Doganay L, Agaoglu NB, Irvem A, Alkurt G, Yildiz J, Kose B, Demirkol YK, Dogan OA, Doganay GD. Responding To COVID-19 In Istanbul: Perspective From Genomic Laboratory. North Clin Istanb. 2020;7(3):311-312. Doi: 10.14744/Nci.2020.30075
- Karacan I, Akgun TK, Agaoglu NB, Irvem A, Alkurt G, Yildiz J, Kose B, Ozel AS, Altunal LN, Can ND, Demirkol YK, Aydin M, Dogan OA, Doganay L, Doganay GD. The Origin Of SARS-CoV-2 In Istanbul: Sequencing Findings From The Epicenter Of The Pandemic In Turkey. North Clin Istanb. 2020;7(3):203-209. Doi: 10.14744/Nci.2020.90532
- Alkurt G., Ahmet M., Aydın Z., Tatlı O., Agaoglu NB., Irvem A., Aydın M., Karaali R., Günes, M., Yeşilyurt B., Türkez H., Mardinoglu A., Doganay M., Basinoglu F., Seyahi N., Dinler Doganay G., Doganay L. Seroprevalence Of Coronavirus Disease 2019 (COVID-19) Among Health Care Workers From Three Pandemic Hospitals Of Turkey, Plos One 2021:16(3): E0247865, Doi: 10.1371/Journal.Pone.0247865
- Dogan O. A., Kose B., Agaoglu N. B., Yildiz J., Alkurt G., Demirkol Y. K., Irvem A., Dinler- Doganay G., L Doganay. Does Sampling Saliva Increase Detection Of SARS-CoV-2 By RT-PCR? Comparing Saliva With Oro-Nasopharyngeal Swabs. J Virologic Methods 2021(290): 114049. Doi: 10.1016/J.Jviromet.2020.114049
- Agaoglu N. B., Yıldız J., Dogan O. A., Alkurt G., Kose B., Demirkol Y., Irvem A., Doganay L., Dinler-Doganay G. COVID-19 PCR Test Performance For Samples Stored At Ambient Temperature, J Virologic Methods Accepted On Publication
- Temiz MZ, Dincer MM, Hacibey I, Yazar RO, Celik C, Kucuk SH, Alkurt G, Doganay L, Yuruk E, Muslumanoglu AY. Investigation Of SARS-CoV-2 In Semen Samples And The Effects Of COVID-19 On Male Sexual Health By Using Semen Analysis And Serum Male Hormone Profile: A Cross-Sectional, Pilot Study. Andrologia. 2020(26): E13912. Doi: 10.1111/And.13912
- Akcay IM, Celik E, Agaoglu NB, Alkurt G, Kizilboga Akgun T, Yildiz J, Enc F, Kir G, Canbek S, Kilic A, Zemheri E, Ezberci F, Ozcelik M, Dinler Doganay G, Doganay L. Germline Pathogenic Variant Spectrum In 25 Cancer Susceptibility Genes In Turkish Breast And Colorectal Cancer Patients And Elderly Controls. Int J Cancer. 2021; 148(2): 285295. Doi: 10.1002/Ijc.33199
- Sayar S., Gökçen P., Aykut H., Adalı G., Doğanay HL, Özdil K. Can Simple Non-Invasive Fibrosis Models Determine Prognostic Indicators (Fibrosis And Treatment Response) Of Primary Biliary Cholangitis? Med Bull Sisli Etfal Hosp 2021;55(3):412–418. Doi: 10.14744/Semb.2021.95825
- Sayar S, Ayranci G, Kürbüz K, Ak Ç, Tarikçi Kiliç E, Kahraman R, Atalay R, Öztürk O, Çalişkan Z, Adali G, Doganay L, Özdil K. High Frequency Of Gastric Cancer Precursor Lesions In Patients With Gastric Xanthelasma: A Prospective Case-Control Study. Eur J Gastroenterol Hepatol. 2020;32(9):1130-1134. Doi:10.1097/MEG.0000000000001795
- Sözeri B, Demir F, Sönmez HE, Karadağ ŞG, Demirkol YK, Doğan ÖA, Doğanay HL, Ayaz NA. Comparison Of The Clinical Diagnostic Criteria And The Results Of The Next Generation Sequence Gene Panel In Patients With Monogenic Systemic Autoinflammatory Diseases. Clin Rheumatol. 2021;40(6):2327-37. Doi: 10.1007/S10067-020-05492-8
- Demir F, Bolac GL, Merter T, Canbek S, Dogan OA, Demirkol YK, Yildiz J, Doganay HL, Sozeri B. The Musculoskeletal System Manifestations In Children With Familial Mediterranean Fever. North Clin Istanb. 2020 4;7(5):438-442. Doi: 10.14744/Nci.2020.96636
- Sayar S, Kürbüz K, Kahraman R, Öztürk O, Çalışkan Z, Doğanay HL, Özdil K. Risk Of Hepatitis B Reactivation During Anti-TNF Therapy; Evaluation Of Patients With Past Hepatitis B Infection. Turk J Gastroenterol. 2020;31(7):522-528. Doi: 10.5152/Tjg.2020.19295
- Demir F, Doğan ÖA, Demirkol YK, Tekkuş KE, Canbek S, Karadağ ŞG, Sönmez HE, Ayaz NA, Doğanay HL, Sözeri B. Genetic Panel Screening In Patients With Clinically Unclassified Systemic Autoinflammatory Diseases. Clin Rheumatol. 2020;39(12):3733-3745. Doi: 10.1007/S10067-020-05108-1
- Sayar S, Kurbuz K, Kahraman R, Caliskan Z, Atalay R, Ozturk O, Doganay HL, Ozdil K. A Practical Marker To Determining Acute Severe Ulcerative Colitis: CRP/Albumin Ratio. North Clin Istanb. 2019:25;7(1):49-55. Doi: 10.14744/Nci.2018.78800
- Bulur A, Ozdil K, Doganay L, Ozturk O, Kahraman R, Demirdag H, Caliskan Z, Mutlu Bilgic N, Kanat E, Serap Erden A, Mehmet Sokmen H. Polypoid Lesions Detected In The Upper Gastrointestinal Endoscopy: A Retrospective Analysis In 19560 Patients, A Single-Center Study Of A 5-Year Experience In Turkey. North Clin Istanb. 2020 Nov 27;8(2):178-185. Doi: 10.14744/Nci.2020.16779
- Sozeri B, Ercan G, Dogan OA, Yıldız J, Demir F, Doğanay L. The Same Mutation In A Family With Adenosine Deaminase 2 Deficiency. Rheumatol Int. 2021;41(1). Doi: 10.1007/S00296-019-04444-Z
- Geyik G, Sahin A, Pekcioglu Y, Okuroglu N, Doganay L, Ozdil K. Is NRS-2002 A Reliable Tool In The Nutritional Assessment Of Cirrhosis: A Comparative Study. Acta Medica Mediterranea. 2021;37(1):43–50
- Güzelbulut F, Gökçen P, Can G, Adalı G, Değirmenci Saltürk AG, Bahadır Ö, Ozdil K., Doganay L. Validation Of The HCC-RESCUE Score To Predict Hepatocellular Carcinoma Risk In Caucasian Chronic Hepatitis B Patients Under Entecavir Or Tenofovir Therapy. Journal Of Viral Hepatitis. 2021;28(5)
- Gokcen P, Cakmak E, Adali G, Dogan HO, Yildiz SN, Ozturk O, Doganay L, Ozdil K. Liver Fatty Acid Binding Protein: Is It An Early Diagnostic And Prognostic Marker In Liver Damage? Medical Science And Discovery. 2021;8(4)
- Sayar S, Atalay R, Çakmak Ş, Ayrancı G, Kürbüz K, Kahraman R, Caliskan Z., Ozturk O., Demirdağ H., Adali G., Ozdil K., Doganay L. Diagnostic Performance Of Non-Invasive Fibrosis Indexes In Hepatitis B Related Fibrosis. Viral Hepatitis Journal. 2020;26(2)
- Değertekin B, Demir M, Akarca US, Kani HT, Üçbilek E, Yıldırım E, Güzelbulut F, Balkan A, Vatansever S, Danış N, Demircan M, Soylu A, Yaras S, Kartal A, Kefeli A, Gündüz F, Yalçın K, Erarslan E, Aladağ M, Harputluoğlu M, Özakyol A, Temel T, Akarsu M, Sümer H, Akın M, Albayrak B, Sen İ, Alkım H, Uyanıkoğlu A, Irak K, Öztaşkın S, Uğurlu ÇB, Güneş Ş, Gürel S, Nuriyev K, İnci İ, Kaçar S, Dinçer D, Doğanay L, Göktürk HS, Mert A, Coşar AM, Dursun H, Atalay R, Akbulut S, Balkan Y, Koklu H, Şimşek H, Özdoğan O, Çoban M. Real-World Efficacy And Safety Of Ledipasvir + Sofosbuvir And Ombitasvir/Paritaprevir/Ritonavir ± Dasabuvir Combination Therapies For Chronic Hepatitis C: A Turkish Experience. Turk J Gastroenterol. 2020 Dec;31(12):883-893. Doi: 10.5152/Tjg.2020.20696
- Çalışkan Z, Demircioglu K, Sayar S., Kahraman R., Caklili Ö, Özcan FB, Köstek Ö, Baycan OF, Doganay L, Caliskan M. Lipid Profile, Atherogenic Indices, And Their Relationship With Epicardial Fat Thickness And Carotid Intima–Media Thickness In Celiac Disease. North Clin Istanb. 2019; 6(3): 242-247. Doi: 10.14744/Nci.2019.54936
- Akcay IM, Katrinli S, Ozdil K, Doganay GD, Doganay L. Host Genetic Factors Affecting Hepatitis B Infection Outcomes: Insights From Genome-Wide Association Studies. World J Gastroenterol. 2018;24(30):3347-3360. Doi: 10.3748/Wjg.V24.I30.3347
- Celik E, Ermis Tekkus K, Akcay IM, Alkurt Sal G, Ezberci F, Dinler Doganay G, Doganay L. Identification Of A BRCA2 Mutation In A Turkish Family With Early-Onset Breast Cancer. Clin Case Rep. 2018;6(9):1751-1755. Doi: 10.1002/Ccr3.1625
- Doganay L. Hepatocellular Cancer: Is Recurrence Inevitable? J Gastrointest Cancer. 2017. Doi: 10.1007/S12029-017-9967-0
- Kilic E, Doganay L, Ozdil K. Endoscopic Retrograde Cholangiopancreaticography In Elderly Patients: A Reliable Alternative In Sepsis. North Clin Istanb. 2018; 5(2): 169-170. Doi: 10.14744/Nci.2018.92679
- Katrinli S, Nigdelioglu A, Ozdil K, Dinler-Doganay G, Doganay L. The Association Of Variations In TLR Genes And Spontaneous Immune Control Of Hepatitis B Virus. Clin Res Hepatol Gastroenterol. 2018;42(2):139-144. Doi: 10.1016/J.Clinre.2017.10.002
- Ozdil K, Caliskan Z, Keles N, Ozturk O, Tekin AS, Kahraman R, Doganay L, Demircioglu K, Yilmaz Y, Caliskan M. Echocardiographic Epicardial Fat Thickness Measurement: A New Screening Test For Subclinic Atherosclerosis In Patients With Inflammatory Bowel Diseases. North Clin Istanb. 2017;4(1):4-12. Doi: 10.14744/Nci.2017.74508
- Katrinli S, Gurbet-Erkut N, Ozdil K, Yilmaz-Enc F, Ozturk O, Kahraman R, Tuncer I, Dinler-Doganay G, Doganay L. HLA DPB1 15:01 Allele Predicts Spontaneus Hepatitis B Surface Antigen Seroconversion. Acta Gastro-Enterologica Belgica. 2017;80(3):351
- Katrinli S, Ozdil K, Sahin A, Kir G, Baykal AT, Akgun E, Sarac OS, Sokmen M, Dinler Doganay G, Doganay L. Proteomic Profiling Of HBV Infected Liver Biopsies With Different Fibrotic Stages. Proteome Science 2017;15:7. Doi: 10.1186/S12953-017-0114-4
- Ozturk O, Doganay L, Colak Y, Yilmaz Enc F, Ulasoglu C, Ozdil K, Tuncer I. Therapeutic Success With Bismuth-Containing Sequential And Quadruple Regimens In Helicobacter Pylori Eradication. Arab Journal Of Gastroenterology, 2017. Doi: 10.1016/J.Ajg.2017.05.002
- Doganay L, Ozdil K, Memisoglu K, Katrinli S, Karakoc E, Nikerel E, Doganay G. Integrating Personalized Genomics To Turkish Health Care System: A Cancer Oriented Pilot Activity Of Istanbul Northern Anatolian Public Hospitals With GLAB. North Clin Istanb. 2017; 4(1):1-3. Doi: 10.14744/Nci.2017.38980
- Katrinli S, Yilmaz Enc F, Ozdil K, Ozturk O, Tuncer I, Dinler Doganay G, Doganay L. Effect Of HLA-DPA1 Alleles On Chronic Hepatitis B Prognosis And Treatment Response. North Clin Istanb 2016;3(3):168-174. Doi: 10.14744/Nci.2016.27870
- Ozdil K., O. Ozturk, E.S. Calik, E.S. Akbas, E. Kanat, Z. Caliskan, H. Demirdag, R. Kahraman, A. Bulur, N.M. Bilgic, Doganay L., H.M. Sokmen. Relationship Between Size Of Varices And Platelet Count/Spleen Size Ratio In Cirrhotic Patients. North Clin Istanb. 2016;3(1):46-52. Doi: 10.14744/Nci.2016.60362
- Ozturk O, Colak Y, Senates E, Yilmaz Y, Ulasoglu C, Doganay L, Ozkanli S, Oltulu YM, Coskunpinar E, Tuncer I. Increased Serum Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels In Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. World J Gastroenterol. 2015;21(26):8096-102. Doi:10.3748/Wjg.V21.I26.8096
- Gonen C, Gunduz F, Doganay L, Enc FY, Yegin EG, Ahishali E, Erdem E, Sokmen M, Tuncer I, Ozdogan O. High Treatment Modification Rates With Lamivudine Therapy In HBV-Infected Patients With Low Baseline Viremia And Early Virological Response: A Multicenter Study. J Dig Dis. 2015 May;16(5):286-92. Doi: 10.1111/1751-2980.12237
- Doganay L, Katrinli S, Colak Y, Senates E, Zemheri E, Ozturk O, Enc FY, Tuncer I, Doganay GD. HLA DQB1 Alleles Are Related With Nonalcoholic Fatty Liver Disease. Mol Biol Rep. 2014;41(12):7937-43. Doi: 10.1007/S11033-014-3688-2
- L. Doganay, A. Fejzullahu, S. Katrinli, F. Yilmaz Enc, O. Ozturk, Y. Colak, C. Ulasoglu, I. Tuncer, G. Dinler Doganay. Association Of Human Leukocyte Antigen DQB1 And DRB1 Alleles With Chronic Hepatitis B. World J Gastroenterol. 2014 Jul 7;20(25):8179-86. Doi: 10.3748/Wjg.V20.I25.8179
- L. Doganay, I. Tuncer, S. Katrinli, F.Y. Enc, O. Ozturk, Y. Colak, C. Ulasoglu, G. Dinler. The Effect Of HLA-DQB1 Alleles On Virologic Breakthroughs During Chronic Hepatitis B Treatment With Genetically Low Barrier Drugs. Clinics And Research In Hepatology And Gastroenterology. 2013 Sep;37(4):359-64. Doi: 10.1016/J.Clinre.2012.10.013
- T. Calhan, R. Kahraman, A. Sahin, E. Senates, H.L. Doganay, E. Kanat, K. Ozdil, H.M. Sokmen. Efficacy Of Two Levofloxacin-Containing Second-Line Therapies For Helicobacter Pylori: A Pilot Study. Helicobacter. 2013 Oct;18(5): 378-83. Doi: 10.1111/Hel.12056
- Y. Yilmaz, O. Ozturk, Y.O. Alahdab, E. Senates, Y. Colak, H.L. Doganay, E. Coskunpinar, Y.M. Oltulu, F. Eren, O. Atug, I. Tuncer, N. Imeryuz. Serum Osteopontin Levels As A Predictor Of Portal Inflammation In Patients With Nonalcoholic Fatty Liver Disease. Digestive And Liver Disease. 2013 Jan;45(1):58-62. Doi: 10.1016/J.Dld.2012.08.017
- L. Doganay, K. Ozdil, M. Sokmen. Last Blood Check Before Passing: Does Alcohol Prevent Fibrosis? The American Journal Of Gastroenterology. 2013 Jun;108(6):1010. Doi: 10.1038/Ajg.2013.74
- Y. Colak, E. Senates, A. Yesil, Y. Yilmaz, O. Ozturk, L. Doganay, E. Coskunpinar, O.T. Kahraman, B. Mesci, C. Ulasoglu, I. Tuncer. Assessment Of Endothelial Function In Patients With Nonalcoholic Fatty Liver Disease. Endocrine. 2013 Feb;43(1):100-7. Doi: 10.1007/S12020-012-9712-1
- C. Ulasoglu, B. Isbilen, L. Doganay, F. Ozen, S. Kiziltas, I. Tuncer. Effect Of Helicobacter Pylori Eradication On Serum Ghrelin And Obestatin Levels. World Journal Of Gastroenterology. 2013 Apr 21;19(15):2388-94. Doi: 10.3748/Wjg.V19.I15.2388
- Y. Colak, I. Tuncer, E. Senates, O. Ozturk, L. Doganay, Y. Yilmaz. Nonalcoholic Fatty Liver Disease: A Nutritional Approach. Metabolic Syndrome And Related Disorders. 2012 Jun;10(3):161-6. Doi: 10.1089/Met.2011.0145
- Y. Colak, E. Senates, E. Coskunpinar, Y.M. Oltulu, E. Zemheri, O. Ozturk, L. Doganay, B. Mesci, Y. Yilmaz, F.Y. Enc, S. Kiziltas, C. Ulasoglu, I. Tuncer. Concentrations Of Connective Tissue Growth Factor In Patients With Nonalcoholic Fatty Liver Disease: Association With Liver Fibrosis. Disease Markers. 2012;33(2):77-83. Doi: 10.3233/Dma2012-0907
- Tuncer, Y. Colak, R. Yigitbasi, E. Zemheri, T. Ayaz, E. Yorulmaz, L. Doganay, O. Ozturk, G. Adali. Mesenteric Inflammatory Veno-Occlusive Disease: An Unusual Cause Of Colonic Ischemia. The Turkish Journal Of Gastroenterology. 2011 Oct;22(5):561-2. Doi: 10.4318/Tjg.2011.0262
- Y. Colak, C.Y. Karabay, I. Tuncer, G. Kocabay, A. Kalayci, E. Senates, O. Ozturk, H.L. Doganay, F.Y. Enc, C. Ulasoglu, S. Kiziltas. Relation Of Epicardial Adipose Tissue And Carotid Intima-Media Thickness In Patients With Nonalcoholic Fatty Liver Disease. European Journal Of Gastroenterology & Hepatology. 2012 Jun;24(6):613-8. Doi: 10.1097/MEG.0b013e3283513f19
- L. Doganay, S. Kiziltas, Y. Colak, M. Gulluoglu, I. Tuncer. Is The Lymphoma Risk Reduced In Viral Hepatitis? A Cirrhotic Patient With Triple Malignancies. The American Journal Of Gastroenterology. 2011 Sep;106(9):1719-20; Author Reply 20. Doi: 10.1038/Ajg.2011.214
- Y. Colak, O. Ozturk, E. Senates, I. Tuncer, E. Yorulmaz, G. Adali, L. Doganay, F.Y. Enc. SIRT1 As A Potential Therapeutic Target For Treatment Of Nonalcoholic Fatty Liver Disease. Medical Science Monitor. 2011 May;17(5):HY5-9. Doi: 10.12659/Msm.881749
- Tuncer, L. Doganay, O. Ozturk. Instant Control Of Fundal Variceal Bleeding With A Folkloric Medicinal Plant Extract: Ankaferd Blood Stopper. Gastrointestinal Endoscopy. 2010 Apr;71(4):873-5. Doi: 10.1016/J.Gie.2009.08.021
- Y. Colak, E. Senates, O. Ozturk, H.L. Doganay, E. Coskunpinar, Y.M. Oltulu, A. Eren, O. Sahin, S. Ozkanli, F.Y. Enc, C. Ulasoglu, I. Tuncer. Association Of Serum Lipoprotein Associated Phospholipase A2 Level With Nonalcoholic Fatty Liver Disease. Metabolic Syndrome And Related Disorders. 2012 Apr;10(2):103-9. Doi: 10.1089/Met.2011.0111
- H.A. Bodur, E. Saygili, S. Saygili, L.H. Doganay, S. Yesil. Continuous Infusion Of Subcutaneous Compared To Intravenous Insulin For Tight Glycaemic Control In Medical Intensive Care Unit Patients. Anaesthesia And Intensive Care. 2008 Jul;36(4):520-7. Doi: 10.1177/0310057X0803600421
- L. Doganay, P.D. Welsby. Anthrax: A Disease In Waiting? Postgraduate Medical Journal. 2006 Nov;82(973):754-6. Doi: 10.1136/Pgmj.2005.044487
- L. Doganay, B. Akinci, N. Pekel, I. Simsek, H. Akpinar. Mesalazine-Induced Myopericarditis In A Patient With Ulcerative Colitis. International Journal Of Colorectal Disease. 2006 Mar;21(2):199-200. Doi: 10.1007/S00384-004-0706-1
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