Asst. Prof. MD. Hasan Kapaklı

Education and Expertise

• 2006 Akdeniz University Faculty of Medicine
• 2012 Harran University Master's Degree in Child Health and Diseases (Specialization Training)
• 2019 Necmettin Erbakan University Doctorate in Pediatric Allergy and Immunology

Master's Theses

• January 2010 - January 2012: Evaluation of DNA Damage and Oxidative Metabolism in Patients with Non-Cystic Fibrosis Bronchiectasis. Thesis Advisor: Prof. Dr. Dost Zeyrek

Experience

• Istanbul Aydın University VM Medical Park Florya

Articles Published in International Peer-Reviewed Journals (SCI & SSCI & Arts and Humanities)

• 1. Sezen Y, Guntekin U, Iscan A, Kapakli H, Buyukhatipoglu H, Kucukdurmaz Z. Rapidly improving, severe, acute myocarditis after a scorpion bite: an extremely rare complication and successful management. Am J Emerg Med. 2010 Sep;28(7):844.e3-5. doi: 10.1016/j.ajem.2009.12.008. Epub 2010 Apr 2. PMID: 20837272.
• 2. Rowe JH, Delmonte OM, Keles S, Stadinski BD, Dobbs AK, Henderson LA, Yamazaki Y, Allende LM, Bonilla FA, Gonzalez-Granado LI, Celikbilek Celik S, Guner SN, Kapakli H, Yee C, Pai SY, Huseby ES, Reisli I, Regueiro JR, Notarangelo LD. Patients with CD3G mutations reveal a role for human CD3γ in Treg diversity and suppressive function. Blood. 2018 May 24;131(21):2335-2344. doi: 10.1182/blood-2018-02-835561. Epub 2018 Apr 13. PMID: 29653965; PMCID: PMC5969384.
• 3. Karaselek MA, Kapaklı H, Keleş S, Güner ŞN, Çelik ŞÇ, Kurar E, Reisli İ. Intrauterine detection of DCLRE1C (Artemis) mutation by restriction fragment length polymorphism. Pediatr Allergy Immunol. 2019 Sep;30(6):668-671. doi: 10.1111/pai.13056. Epub 2019 Jun 26. PMID: 30947362.
• 4. Kiykim A, Ogulur I, Dursun E, Charbonnier LM, Nain E, Cekic S, Dogruel D, Karaca NE, Cogurlu MT, Bilir OA, Cansever M, Kapakli H, Baser D, Kasap N, Kutlug S, Altintas DU, Al-Shaibi A, Agrebi N, Kara M, Guven A, Somer A, Aydogmus C, Ayaz NA, Metin A, Aydogan M, Uncuoglu A, Patiroglu T, Yildiran A, Guner SN, Keles S, Reisli I, Aksu G, Kutukculer N, Kilic SS, Yilmaz M, Karakoc-Aydiner E, Lo B, Ozen A, Chatila TA, Baris S. Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency. J Allergy Clin Immunol Pract. 2019 Nov-Dec;7(8):2790-2800.e15. doi: 10.1016/j.jaip.2019.06.011. Epub 2019 Jun 22. PMID: 31238161; PMCID: PMC6842687.
• 5. Sancho-Shimizu V, Brodin P, Cobat A, Biggs CM, Toubiana J, Lucas CL, Henrickson SE, Belot A; MIS-C@CHGE, Tangye SG, Milner JD, Levin M, Abel L, Bogunovic D, Casanova JL, Zhang SY. SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease? J Exp Med. 2021 Jun 7;218(6):e20210446. doi: 10.1084/jem.20210446. PMID: 33904890; PMCID: PMC8080850.
• 6. Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N, Schneider WM, Razooky BS, Hoffmann HH, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus AL, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schlüter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen SZ, Alsohime F, Al Turki S, Hasanato R, van de Beek D, Biondi A, Bettini LR, D'Angio' M, Bonfanti P, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Oler AJ, Tompkins MF, Alba C, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Soler-Palacin P, Martin-Nalda A, Colobran R, Morange PE, Keles S, Çölkesen F, Ozcelik T, Yasar KK, Senoglu S, Karabela ŞN, Rodríguez-Gallego C, Novelli G, Hraiech S, Tandjaoui-Lambiotte Y, Duval X, Laouénan C; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort; NIAID-USUHS/TAGC COVID Immunity Group, Snow AL, Dalgard CL, Milner JD, Vinh DC, Mogensen TH, Marr N, Spaan AN, Boisson B, Boisson-Dupuis S, Bustamante J, Puel A, Ciancanelli MJ, Meyts I, Maniatis T, Soumelis V, Amara A, Nussenzweig M, García-Sastre A, Krammer F, Pujol A, Duffy D, Lifton RP, Zhang SY, Gorochov G, Béziat V, Jouanguy E, Sancho-Shimizu V, Rice CM, Abel L, Notarangelo LD, Cobat A, Su HC, Casanova JL. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science. 2020 Oct 23;370(6515):eabd4570. doi: 10.1126/science.abd4570. Epub 2020 Sep 24. PMID: 32972995; PMCID: PMC7857407.
• 7. Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen JI, Biondi A, Bettini LR, D'Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J; HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort, Tsang JS, Goldbach-Mansky R, Kisand K, Lionakis MS, Puel A, Zhang SY, Holland SM, Gorochov G, Jouanguy E, Rice CM, Cobat A, Notarangelo LD, Abel L, Su HC, Casanova JL. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020 Oct 23;370(6515):eabd4585. doi: 10.1126/science.abd4585. Epub 2020 Sep 24. PMID: 32972996; PMCID: PMC7857397.
• 8. Yahya Gul, Hasan Kapakli, Sukru Nail Guner, Havva Bozkurt Alan, Esra Hazar, Sevgi Keles, Ismail Reisli. Long-Term Experience of Subcutaneous Immunoglobulin Therapy in Pediatric Primary Immunodeficient Patients with Low and Normal Body Weight. J Clin Immunol 2022 Jan;42(1):64-71. doi: 10.1007/s10875-021-01144-x. Epub 2021 Oct 7. PMID: 34617265
• 9. Gul Y, Kapaklı H, Aytekin SE, Guner ŞN, Keles S, Zamani AG, Yıldırım MS, Reisli Ï. Evaluation of immunological abnormalities in patients with rare syndromes. Cent Eur J Immunol. 2022;47(4):299-307. doi: 10.5114/ceji.2022.124080. Epub 2023 Jan 31. PMID: 36817395
• 10. Gul Y, Hazar E, Kapaklı H, Guner ŞN, Nayir R, Kutuk S, Köker MY, Keleş S, Reisli İ. Chronic granulomatous disease: A single-center experience in Central Anatolia. Pediatr Neonatol. 2024 Jun 17:S1875-9572(24)00093-7. doi: 10.1016/j.pedneo.2024.02.008. Online ahead of print. PMID: 38918167
• 11. Yilmaz Aİ, Gül Y, Kapaklı H, Ünal G, Çağlar HT, Ercan F, Reisli İ, Keleş S, Poyraz N, Pekcan S. Successful treatment of postinfectious bronchiolitis obliterans with gamma globulin in a tertiary center: 10 years of experience. Pediatr Pulmonol. 2023 Oct;58(10):2769-2776. doi: 10.1002/ppul.26577. Epub 2023 Jul 20. PMID: 37469295

Articles Published in Other International Peer-Reviewed Journals

Presentations at International Scientific Meetings and Published in Proceedings

• 1. Kapaklı H. Case Presentation of LRBA Gene Defect (LRBA Gen Defekli Olan Olgu Sunumu), 4th International Clinical Immunology Congress, Turkey, Antalya 2018.
• 2. Kapaklı H. Artemis Deficiency, Spring School for Primary Immunodeficiencies, The Czech Republic, Kutna Hora 2018 (Oral Presentation).
• 3. Kapaklı H. Clinical and Laboratory Features of Our Cases Followed with IL-10 Receptor Defect (IL-10 Reseptör Defekti ile Takip Edile Vakalarımızın Klinik ve Laboratuar Özellikleri), 5th Erciyes Pediatric Academy Winter Congress February 28 - March 2, Kayseri 2019
• 4. Kapaklı H. Clinical Reflection of Intravenous Immunoglobulin Treatment in Cases of Severe Bronchiolitis Obliterans (Ağır Seyirli Bronşiolitis Obliterans Olgularında İntravenöz İmmunglobulin Tedavisinin Kliniğe Yansıması), 41st National Respiratory Congress October 26-29, Bodrum
• 5. Kapaklı H. Clinical and Laboratory Features of the Patients with Kabuki Make-Up Syndrome, 1st International Rumi Pediatrics Congress December 4-7, Konya

International Books or Book Chapters Authored

• Kapaklı H, Güner ŞN. Rare Diseases in Children Focusing on Pediatric Immunology & Neurology Interleukin-10 receptor deficiency:2020.

Articles Published in National Peer-Reviewed Journals

• Kapaklı H. The Relationship between Inflammatory Bowel Diseases and Immune Deficiencies (İnflamatuar Bağırsak Hastalıklarının İmmün Yetmezliklerle İlişkisi), Türkiye Klinikleri Immunology Allergy-Special Topics 2020;13(1):33-37

Presentations at National Scientific Meetings and Published in Proceedings

• 1. Pekcandanoğlu TE, Çelikbilek ÇŞ, Keyik S, Karaselek MA, Keleş S, Hazar Sayar E, Kapaklı H, Güner SN, Reisli İ. Flow cytometric evaluation of DOCK8 protein expression (DOCK8 protein ekspresyonun akım sitometrik olarak değerlendirilmesi), 3rd Clinical Immunology Congress, İzmir 2017.
• 2. Keyik S, Pekcandanoğlu TE, Çelikbilek ÇŞ, Karaselek MA, Keleş S, Hazar Sayar E, Kapaklı H, Güner SN, Reisli İ. Flow cytometric evaluation of LRBA protein expression (LRBA protein ekspresyonun akım sitometrik olarak değerlendirilmesi), 3rd Clinical Immunology Congress, İzmir 2017.
• 3. Kapaklı H, Karaselek MA, Kaya A, Gül Y, Hazar Sayar E, Tokgöz H, Güner ŞN, Çalışkan Ü, Keleş S, Reisli İ. Case Presentation of Acute Lymphoblastic Leukemia and Artemis Gene Defect (Akut Lenfoblastik Lösemi Ve Artemis Gen Defektli Olgu Sunumu), 5th Clinical Immunology Congress, Antalya 2019.
• 4. Efe Hİ, Karaselek MA, Kapaklı H, Gül Y, Güner ŞN, Keleş S, Reisli İ. Use of RFLP method in the diagnosis of CD19 deficiency (RFLP yönteminin CD19 eksikliği tanısında kullanılması), 5th Clinical Immunology Congress, Antalya 2019.
• 5. Karaselek MA, Keleş S, Kurar E, Kapaklı H, Çelikbilek ÇŞ, Doğan H, Güner ŞN, Reisli İ. Immunological, Functional, and Genetic Studies in NK Disease (NK Hastalığında İmmünolojik, Fonksiyonel ve Genetik Çalışmalar), 6th Clinical Immunology Congress, Antalya 2020.
• 6. Aytekin SE, Karaselek MA, Gül Y, Kapaklı H, Güner ŞN, Keleş S, Reisli İ. A Rare Immune Deficiency Case Accompanied by Neutropenia Due to Functional NK Deficiency (Fonksiyonel NK Eksikliğine Nötropeninin Eşlik Ettiği Nadir Bir İmmün Yetmezlik Olgusu), 6th Clinical Immunology Congress, Antalya 2020.
• 7. Kapaklı Hasan Intravenous Immunoglobulin (IVIG) Use in Immune Deficiency (İmmün Yetmezlikte İntraVenöz İmmunglobulin (IVIG) Kullanımı), 4th Young Pediatric Allergists Symposium, Adana 2022.

Other Publications

• Kapaklı H. Turkish National Clinical Immunology and Allergy Association Legal Guide for Immunologists and Allergists, Patient informed consent forms 2020 (Türkiye Ulusal Klinik İmmunoloji ve Alerji Derneği İmmunoloji ve Alerji Uzmanları İçin Hukuk Rehberi, Hasta aydınlatılmış onam formları 2020).

Projects

• 1. Necmettin Erbakan University Scientific Research Projects
  • Project Title: Determination of Mutations in Exon 3 and Exon 14 of DCLRE1C (ARTEMIS) in Patients Diagnosed with Severe Combined and Combined Immunodeficiency
  • Project Number: 171218021
  • Role: Assistant Researcher
  • Start and End Date: 10/12/2017-10/11/2018
• 2. Necmettin Erbakan University Scientific Research Projects
  • Project Title: Screening Protocol for Genetic Diseases Related to Lymphocyte Homeostasis and Programmed Cell Death
  • Project Number: 182018008
  • Role: Assistant Researcher
  • Start and End Date: 10/05/2018–04/05/2021
• 3. Necmettin Erbakan University Scientific Research Projects
  • Project Title: Sample Collection to Determine the Genetic and Immunological Characteristics of Primary Immunodeficiencies (NIH-NEU joint study)
  • Project Number: 192018006
  • Position: Research Assistant
  • Start and End Date: 07/24/2019-07/24/2021

Awards

• First Prize for Poster Presentation

  Pekcandanoğlu TE, Çelikbilek ÇŞ, Keyik S, Karaselek MA, Keleş S, Hazar Sayar E, Kapaklı H, Güner SN, Reisli İ. Flow cytometric evaluation of DOCK8 protein expression, 3rd Clinical Immunology Congress, Izmir 2017.