Prof. MD. Hüseyin İlksen Toprak

Education and Specialization

• 1986-1992: Ege University Faculty of Medicine, Medical Doctor (M.D.)
• 1992-1997: Malatya Hekimhan Tuberculosis Control Dispensary, General Practitioner (Experience/Duty)
• 1997-2001: İnönü University Faculty of Medicine, Department of Anesthesiology and Reanimation, Specialist Physician (Residency)
• 2001-2007: İnönü University Faculty of Medicine, Department of Anesthesiology and Reanimation, Assistant Professor (Dr. Öğr. Üyesi)
• 2007-2013: İnönü University Faculty of Medicine, Department of Anesthesiology and Reanimation, Associate Professor
• 2013-2021: İnönü University Faculty of Medicine, Department of Anesthesiology and Reanimation, Professor
• 2021- Present: İstanbul Aydın University Faculty of Medicine, Department of Anesthesiology and Reanimation, Professor

Experience

• 2012: King's College Liver Transplantation Clinic (Observer/Visitor)
• 2016: Essen University Liver Transplantation Clinic (Observer/Visitor)

Foreign Language

• English

Professional Memberships

• Turkish Society of Anesthesiology and Reanimation
• Turkish Society of Intensive Care
• Turkish Society of Cardiothoracic and Vascular Anesthesia and Intensive Care

A. Articles Published in International Peer-Reviewed Journals

• A1. Turköz A., Togal T., Gokdeniz R., Toprak H. I. and Ersoy O., “Effectiveness of Intravenous Ephedrine Infusion During Spinal Anaesthesia for Caesarean Section Based on Maternal Hypotension, Neonatal Acid-base Status and Lactate Levels”, Anaesth Intensive Care, 30, 316-320 (2002).
• A2. Türköz A., Toprak İ.H., Köroğlu A., Durmuş M., But A.K. and Ersoy M.Ö., “Anesthetic Management and Endovascular Stent Grafting of Abdominal Aortic Aneurysm in A Patient with Behçet’s Disease (Case Report)”, J Cardiothorac Vasc Anesth, 16, 468-470 (2002).
• A3. Durmus M., Turköz A., Togal T., Koroglu A., Toprak H.I. and Ersoy M.Ö., “Remifentanil and Acute Intermittent Porphyria (Correspondence)”, Eur J Anaesth, 19, 839-840 (2002).
• A4. Turköz A., Toprak H.I., Ersoy M.Ö., Gulcan O. and Turköz R., “Secondary Cross-Clamping and Blood Cardioplegia for Refractory Ventricular Fibrillation After Aortic Cross-Clamp Removal”, Tex Heart Inst J, 29, 230-231 (2002).
• A5. Erdil N., Nisanoglu V., Toprak H.I., Erdil F.A., Kuzucu A. and Battaloglu B., “Arterial Myocardial Revascularization Using Bilateral Radial Artery. 17 Years After Right Pneumonectomy”, Tex Heart Inst J, 31, 96-98 (2004).
• A6. Toprak H.İ., Gedik E., Begeç Z., Öztürk E., Kaya B. and Ersoy M.Ö., “Sevoflurane: As An Alternative Anaesthetic for Electroconvulsive Therapy”, J ECT, 21, 108-110 (2005).
• A7. But A.K., Durmus M., Toprak H.I., Ozturk E., Demirbilek S. and Ersoy M.Ö., “Hemodynamic, Hepatorenal, and Postoperative Effects of Desflurane-Fentanyl and Midazolam-Fentanyl Anesthesia in Coronary Artery Bypass Surgery”, J Cardiothorac Vasc Anesth, 19, 597-602 (2005).
• A8. Toprak H.İ., Ozpolat Z., Ozturk E., Ulger M.H., Sagir O. and Ersoy M.Ö., “Hyperbaric Bupivacaine Affects the Doses of Midazolam Required for Sedation After Spinal Anaesthesia”, Eur J Anaesth, 22: 904-906 (2005).
• A9. Koroglu A., Teksan H., Sagir O., Yucel A., Toprak H.I. and Ersoy M.Ö., “A Comparison of the Sedative, Hemodynamic, and Respiratory Effects of Dexmedetomidine and Propofol in Children Undergoing Magnetic Resonance Imaging”, Anesth Analg, 103, 63-7 (2006).
• A10. But A.K., Ozgul U., Erdil F., Gulhas N., Toprak H.I., Durmus M. and Ersoy M.Ö., “The Effects of Pre-operative Dexmedetomidine Infusion on Hemodynamics in Patients with Pulmonary Hypertension Undergoing Mitral Valve Replacement Surgery”, Acta Anaesthesiol Scand, 50, 1207–1212 (2006).
• A11. Sagir O., Gulhas N., Toprak H., Yucel A., Begec Z. and Ersoy M.Ö., “Control of Shivering during Regional Anaesthesia: Prophylactic Ketamine and Granisetron”, Acta Anaesthesiol Scand, 51, 44–49 (2007).
• A12. Durmus M., But A.K., Saricicek V., Toprak H.I. and Ersoy M.Ö., “The Post-operative Analgesic Effects of a Combination of Gabapentin and Paracetamol in Patients Undergoing Abdominal Hysterectomy: A Randomized Clinical Trial”, Acta Anaesthesiol Scand, 51, 299-304 (2007).
• A13. Ugras Y.M., Toprak H.I., Gunen H., Yucel A. and Gunes A., “Instillation of Skin, Nephrostomy Tract and Renal Puncture Site with Ropivacaine Decreases Pain and Improves Ventilatory Function After Percutaneous Nephrolithotomy”, J Endourol, 21, 499-503 (2007).
• A14. Begec Z., Toprak H.I., Yetkin G., Kuzucu C. and Ersoy M.Ö., “Comparison of the Antibacterial Activity of Lidocaine 1% Versus Alkalinized Lidocaine In Vitro”, Curr Ther Res Clin Exp, 68, 242-248 (2007).
• A15. Koroglu A., Cicek M., Toprak H.I., Karakoc Y., Noyan F. and Ersoy O.M., “Comparison of the Effects of Desflurane and Sevoflurane on the Expression of Platelet Surface Glycoproteins in Unstimulated and Adenosine Diphosphate-Induced Platelets in-vitro”, J Clin Anesth, 19, 328-333 (2007).
• A16. Begec Z., Demirbilek S., Onal D., Erdil F., Toprak H.I. and Ersoy M.Ö., “Dexmedetomidine blunts acute hyperdynamic responses to electroconvulsive therapy without altering seizure duration”, Acta Anaesthesiol Scand, 52, 302-306 (2008).
• A17. Begec Z., Demirbilek S., Onal D., Erdil F., Toprak H.I. and Ersoy M.Ö., “Ketamine or alfentanil administration prior to propofol anaesthesia: the effects on ProSeal™ laryngeal mask airway insertion conditions and haemodynamic changes in children”, Anaesthesia, 64, 282-286 (2009).
• A18. Togal T., Yucel N., Gedik E., Gulhas N., Toprak H.I. and Ersoy M.Ö., “Obstetric admissions to the intensive care unit in a tertiary referral hospital”, Journal of Critical Care, 25, 628-633 (2010).
• A19. Toprak H.İ., Şener A., Gedik E., Uçar M., Karahan K., Aydogan M.S. and Ersoy M.Ö., “Bispectral Index Monitoring to Guide End-Tidal Isoflurane Concentration at Three Phases of Operation in Patients With End-Stage Liver Disease Undergoing Orthotopic Liver Transplantation”, Transplantation Proceedings, 43, 892-5 (2011).
• A20. Toprak H.I., Şahin T., Aslan S., Karahan K., Sanli M. and Ersoy M.Ö., “Effects of desflurane and isoflurane on hepatic and renal functions and coagulation profile during donor hepatectomy”, Transplantation Proceedings, 44, 1635-39 (2012).
• A21. Ozen I., Togal T., Aydogan M.S., Erdogan M.A., Nakir H., Gulhas N., Toprak H.I. and Ersoy M.Ö., “Thromboelastographic comparison of the effects of different fluid preloading regimens delivered before spinal anesthesia”, HealthMED, 6: 3488-94 (2012).
• A22. Sagir O., Noyan F. Yucesoy, Koroglu A., Cicek M. and Toprak H.I., “Comparison between the effects of rocuronium, vecuronium, and cisatracurium using train-of-four and clinical tests in elderly patients”, Anesthesiology and Pain Medicine, 2: 142-8 (2013).
• A23. Begeç Z., Erdoğan Kayhan G., Toprak H.İ., Şahin T., Konur H., Çolak C., Durmuş M. and Ersoy M.Ö., “Sevoflurane alone and propofol with or without remifentanil for electroconvulsive therapy—a randomised, crossover study” Anaesth Intensive Care, 41, 202-206 (2013).
• A24. Şahin T., Begeç Z., Toprak H.I., Polat A., Vardi N., Yücel A., Durmus M. and Ersoy M.Ö., “The Effects of Dexmedetomidine on Liver Ischemia-Reperfusion Injury in Rats”, J Surg Res, 183, 385-390 (2013).
• A25. Akbulut S., Kayaalp C., Yilmaz M., Ince V., Ozgor D., Karabulut K., Eris C., Toprak HI., Aydin C. and Yilmaz S., “Effect of autotransfusion system on tumor recurrence and survival in hepatocellular carcinoma patients”, World J Gastroenterol, 19: 1625-1631 (2013).
• A26. Aydogan MS., Ozgül U., Erdogan MA., Gulhas N., Toprak HI., Durmus M., “Intraoperative Anaphylactic Shock Due to Latex Allergy: Case Report”, Medicine Science, doi: 10.5455/medscience.2013.02.8055.
• A27. Ozgül U., Ucar M., Erdogan MA., Aydogan MS., Toprak HI., Colak C., Durmus M. and Ersoy MO., “Effects of isoflurane and propofol on hepatic and renal functions and coagulation profile after right hepatectomy in living donors”, Transplant Proc, 45: 966-70 (2013).
• A28. Aydogan MS., Erdogan MA., Yucel A., Konur H., Bentli R., Toprak HI. and Durmus M., “Effect of preoperative iron deficiency in liver transplant recipients on length of intensive care unit stay”, Transplant Proc, 45: 978-81 (2013).
• A29. Aydogan MS., Erdogan MA., Yucel A., Konur H., Bentli R., Toprak HI. and Durmuş M., “Effects of Preoperative Iron Deficiency on Transfusion Requirements in Liver Transplantation Recipients: A Prospective Observational Study”, Transplant Proc, 45: 2277-2282 (2013).
• A30. Yilmaz S., Kayaalp C., Ara C., Yilmaz M., Isik B., Aydin C., Ozgor D., Dirican A., Barut B., Unal B., Piskin T., Ates M., Kutlu R., Toprak HI., Bayindir Y., Kirimlioglu H., Aladag M., Harputluoglu M., Selimoglu A., Karabiber H., Yalcin K. and Kirimlioglu V., “Single-Center Analysis of the First 304 Living-Donor Liver Transplantations in 3 Years”, Hepatogastroenterology, 60: 1105-9 (2013).
• A31. Bucak N., Begec Z., Erdil F., Toprak H.İ., Elbozan Cumurcu B., Demirtaş Y., Yoloğlu S., Durmuş M. and Ersoy M.Ö., “Postoperative Cognitive Dysfunction in Living Liver Transplant Donors”, Experimental and Clinical Transplantation, Suppl 1: 81-85 (2014).
• A32. Ucar M., Ozgül U., Polat A., Toprak H.I., Erdogan M.A., Aydogan M.S., Durmus M. and Ersoy M.O., “Comparison of Antioxidant Effects of Isoflurane and Propofol in Patients Undergoing Donor Hepatectomy”, Transplant Proc, 47: 469-472 (2015).
• A33. Bicakcioglu M., Aydogan M.S., Sayan H., Toprak H.I., Isik B., Yılmaz S. and Yologlu S., “Effects of Different Positive End-Expiratory Pressure Values on Liver Function and Indocyanine Green Clearance Test in Liver Transplantation Donors: A Prospective, Randomized, Double-Blind Study”, Transplant Proc, 47: 1190-1193 (2015).
• A34. Sayan H., Aydogan M.S., Bicakcioglu M., Toprak H.I., Isık B. and Yılmaz S., “Effects of Thoracic Epidural Anesthesia on Liver Blood Flow and Indocyanine Green Clearance Test in Living-Donor Liver Transplantation: A Prospective, Randomized, Double-Blind Study”, Transplant Proc, 47: 1462-1465 (2015).
• A35. Demir A., Aydınlı B., Toprak H.I., Karadeniz Ü., Yılmaz F.M., Züngün C., Uçar P., Güçlü Ç.Y., Bostancı E.B. and Yılmaz S., “Impact of 6% Starch 130/0.4 and 4% Gelatin Infusion on Kidney Function in Living-Donor Liver Transplantation”, Transplant Proc, 47: 1883-1889 (2015).
• A36. Gedik E., Bıçakçıoğlu M., Otan E., Toprak H. İlksen, Işık B., Aydın C., Kayaalp C., Yılmaz S., “The 2-stage liver transplant: 3 clinical scenarios”, Exp Clin Transplant, 13 (Suppl 1): 286-9 (2015).
• A37. Gedik E., Toprak H. İlksen, Koca E., Şahin T., Özgül Ü., Ersoy M.Ö., “Blood glucose regulation during living-donor liver transplant surgery”, Exp Clin Transplant, 13 (Suppl 1): 294-300 (2015).
• A38. Ince V., Ozdemir F., Bayindir Y., Toprak HI., Harputluoglu M., Kutlu R., Isik B., Kayaalp C., Yilmaz S., “Liver Transplant in Patients with Viral Hepatitis and Human Immunodeficiency Virus Coinfection: The First 2 Cases in Turkey”, Exp Clin Transplant, doi: 10.6002/ect.2015.0036. (2016).
• A39. Konur H., Erdogan Kayhan G., Toprak HI., Bucak N., Aydogan MS., Yologlu S., Durmus M., Yılmaz S., “Evaluation of pleth variability index as a predictor of fluid responsiveness during orthotopic liver transplantation”, Kaohsiung Journal of Medical Sciences, 32: 373-80 (2016).
• A40. Kıtlık A., Erdogan MA., Ozgul U., Aydogan MS., Ucar M., Toprak HI., Colak C., Durmus M., “Ultrasound-guided transversus abdominis plane block for postoperative analgesia in living liver donors: A prospective, randomized, double-blinded clinical trial”, J Clin Anesth, 37: 103-7 (2017).
• A41. Piskin T., Unal B., Kutluturk K., Yildirim IO., Berktas B., Dogan SM., Yagmur J., Coskun EI., Turkcuoglu I., Beytur A., Sanli M., Colak YZ., Otlu G., Taskapan H., Sahin I., Tabel Y., Kayabas U., Sarac K. and Toprak H.I., “Outcomes of Kidney Transplantations From the Same Deceased Donor to Two Different Recipients: A Single-Center Experience”, Transplantation Proceedings, 49, 460-463 (2017).
• A42. Erdoğan MA., Ozgul U., Ucar M., Yalin M.R., Colak Y.Z., Colak C. and Toprak H.I., “Effect of transversus abdominis plane block in combination with general anesthesia on perioperative opioid consumption, hemodynamics, and recovery in living liver donors: The prospective, double-blinded, randomized study, Clin Transplant, 31 (2017). (doi: 10.1111/ctr.12931).
• A43. Erdoğan Kayhan G., Colak YZ., Sanli M., Ucar M., Toprak H.I., “Accuracy of non-invasive hemoglobin monitoring by pulse CO-oximeter during liver transplantation”, Minerva Anestesiologica, 83, 485-492 (2017).
• A44. Habre W., Disma N., Virag K., Becke K., Hansen TG., Jöhr M., Leva B., Morton NS., Vermeulen PM., Zielinska M., Boda K., Veyckemans F; APRICOT Group of the European Society of Anaesthesiology Clinical Trial Network, “Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe”, Lancet Respir Med, 5: 412-425 (2017). (doi: 10.1016/S2213-2600(17)30116-9. Epub 2017 Mar 28.)
• A45. Ince V., Kayaalp C., Otan E., Ozdemir F., Dirican A., Toprak H.I., Aydin C., Ara C., Yilmaz S., “Living Donor Re-transplantation for Repeated Acute Liver Failure”, Int J Org Transplant Med; 9: 50-2 (2018).
• A46. Ertugay S., Kudsioğlu T., Şen T., Yıldırır A., Vural A.H., Demir A., Ünal E.U., Toprak H.İ. and Patient Blood Management Study Group Members, “Consensus Report on Patient Blood Management in Cardiac Surgery by Turkish Society of Cardiovascular Surgery (TSCVS), Turkish Society of Cardiology (TSC), and Society of Cardio-Vascular-Thoracic Anaesthesia and Intensive Care (SCTAIC)”, Turk Gogus Kalp Damar Cerrahisi Derg, 27: 429-450 (2019).
• A47. Colak Y.Z., Toprak H.I., “Feasibility, safety, and economic consequences of using low flow anesthesia according to body weight”, J Anesth, 34: 537–542 (2020). (DOI: 10.1007/s00540-020-02782-y)
• A48. Unal D., Senayli Y., Polat R., Spahn D.R., Toraman F., Alkis N; Turkish Society of Anaesthesiology and Reanimation Patient Blood Management Group; Turkish National Perioperative Transfusion Study, “Peri-operative blood transfusion in elective major surgery: incidence, indications and outcome. An observational multicentre study”, Blood Transfus, 18: 261-279 (2020). doi: 10.2450/2020.0011-20.
• A49. Weiss R., Saadat-Gilani K., Kerschke L., Wempe C., Meersch M., Zarbock A., the EPIS-AKI Investigators, “EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): study protocol for a multicentre, observational trial”, BMJ Open, 11:e055705 (2021).
• A50. Colak Y.Z., Toprak H.I., “Feasibility, safety, and economic consequences of using minimal flow anaesthesia by Maquet FLOW-i equipped with automated gas control”, Sci Rep, 11: 20074 (2021).
• A51. Zarbock A., Weiss R., Albert F., Rutledge K., Kellum JA., Bellomo R., Grigoryev E., Candela-Toha AM., Demir ZA., Legros V., Rosenberger P., Galán Menéndez P., Garcia Alvarez M., Peng K., Léger M., Khalel W., Orhan-Sungur M., Meersch M.; The EPIS-AKI Investigators, “Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study”, Intensive Care Med. 2023 Jul 28. doi: 10.1007/s00134-023-07169-7. Epub ahead of print. PMID: 37505258, (2023).
• A52. Demiroz D., Colak YZ., Ozdes OO., Ucar M., Erdogan MA., Toprak Hİ., Karakas S., Tasolar SD., Aydın C., Varol I., “Incidence and risk factors of acute kidney injury in pediatric liver transplant patients: A retrospective study”, Indian Journal of Critical Care Medicine: 10.5005/jp-journals-10071-24616 (2024).
• A53. Meersch M., Weiss R., Straub C., Albert F., Booke H., Forni L., Pittet JF., Kellum JA., Rosner M., Mehta R., Bellomo R., Rosenberger P., Zarbock A., on behalf of the EPIS-AKI Investigators, “Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial”, Intensive Care Med, doi.org/10.1007/s00134-023-07314-2 (2024).