Assoc. Prof. MD. Osman Metin İpcioğlu

Education and Training

• Graduate, GATA Military Medical Faculty, Etlik, Ankara

• Specialty Training

  • GATA Haydarpaşa Training Hospital, Biochemistry and Clinical Biochemistry Service, Üsküdar, Istanbul

• Doctoral Training

  • Department of Histology and Embryology, Fırat University, Elazığ

  • Transgenic PAI-1 Mutation Project, FCVRI, Northwestern University, Chicago, USA

Professional Experience

• Biochemistry Specialist, Ersoy Hospital, Istanbul

• Biochemistry Specialist, Türkan Saylan Medical Center, Istanbul

• Visiting Scholar, FCVRI, Northwestern University, Chicago, USA

• Associate Professor, GATA Haydarpaşa Training Hospital, Medical Biochemistry Service, Istanbul

• Assistant Professor, GATA Haydarpaşa Training Hospital, Medical Biochemistry Service, Istanbul

• Biochemistry Specialist (Full-time), Elazığ Military Hospital, Elazığ

• Biochemistry Specialist (Part-time), Ufuk Private Medical Center and Maternity, Elazığ

• Emergency Physician, Turkish Task Force Command Hospital, Zenica, Bosnia and Herzegovina

• General Practitioner, 4th Mechanized Brigade 30-Bed Mobile Surgical Hospital, Chief Physician, Keşan, Edirne

• Intern, GATA, Gülhane Faculty of Medicine, Ankara

Courses and Memberships

• Experimental Research Course – Erciyes University, Hakan Çetinsaya Experimental and Clinical Research Center, Kayseri

• Experimental Research Course – GATA, Ankara

• Experimental Research Application Course – GATA Haydarpaşa Experimental Research and Application Laboratory, Istanbul

International Peer-Reviewed Journal Publications

• Coşar A, Ipçioğlu OM, Ozcan O, Gültepe M. Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry. Turk J Med Sci. 2014;44(1):1-9. Review.

• Karakas DO, Yigitler C, Gulec B, Kucukodaci Z, Ipcioglu OM, Akin ML. Comparison of 4 % icodextrin and omega 3 Fatty acids in prevention of peritoneal adhesions. Indian J Surg. 2014 Jun;76(3):181-6.

• Tanoglu A, Yazgan Y, Kaplan M, Berber U, Kara M, Demırel D, Ipcioglu OM. Trimetazidine significantly reduces cerulein-induced pancreatic apoptosis. Clin Res Hepatol Gastroenterol. 2014 Jul 4. pii: S2210-7401(14)00148-X.

• Kaplan M, Yazgan Y, Tanoglu A, Berber U, Oncu K, Kara M, Demirel D, Kucuk I, Ozari HO, Ipcioglu OM. Effectiveness of interleukin-1 receptor antagonist (Anakinra) on cerulein-induced experimental acute pancreatitis in rats. Scand J Gastroenterol. 2014 Sep;49(9):1124-30.

• Cincik H, Erkul E, Pinar D, Ipcioglu O, Gungor A, Cekin E, Cakmak A. Evaluation of MMP-9 and TIMP-1 Levels of the Patients with Nasal Polyposis After Corticosteroid Therapies. Indian J Otolaryngol Head Neck Surg. 2013 Aug;65(Suppl 2):445-9.

• Iskeleli G, Karakoc Y, Ozkok A, Arici C, Ozcan O, Ipcioglu O. Comparison of the effects of first and second generation silicone hydrogel contact lens wear on tear film osmolarity. Int J Ophthalmol. 2013 Oct 18;6(5):666-70.

• Dinc C, Iplikcioglu AC, Atabey C, Eroglu A, Topuz K, Ipcioglu O, Demirel D. Comparison of deferoxamine and methylprednisolone: protective effect of pharmacological agents on lipid peroxidation in spinal cord injury in rats. Spine (Phila Pa 1976). 2013 Dec 15;38(26):E1649-55.

• Oncu K, Yazgan Y, Tanoglu A, Kaplan M, Ermis F, Ipcioglu OM, Kara M, Kucuk I, Ozari HO. Can serum fetuin-A be regarded as an inflammatory marker among patients with familial Mediterranean fever? Dig Dis Sci. 2013 Nov;58(11):3212-7.

• Cosar A, Ipcioglu OM. Detection of functional vitamin B12 and folate deficiencies, while serum levels are normal. Blood Transfus. 2014 Jan;12 Suppl 1:s164. doi: 10.2450/2013.0040-13. Epub 2013 Apr 17.

• Cosar A, Ipcioglu OM. Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism. Nutrition. 2013 Sep;29(9):1170.

• Cosar A, Ipcioglu OM. Elderly women: homocysteine reduction by short-term folic acid supplementation resulting in increased glucose concentrations and affecting lipid metabolism (C677T MTHFR polymorphism). Nutrition. 2013 Sep;29(9):1171.

• Cekmez F, Canpolat FE, Pirgon O, Aydemir G, Tanju IA, Genc FA, Tunc T, Aydinöz S, Yildirim S, Ipcioglu OM, Sarici SU. Adiponectin and visfatin levels in extremely low birth weight infants; they are also at risk for insulin resistance. Eur Rev Med Pharmacol Sci. 2013 Feb;17(4):501-6.

• Zeren S, Kesici S, Kesici U, Isbilir S, Turkmen UA, Ulusoy H, Karpuz V, Ozcan O, Polat E, Ipcioglu OM, Sari MK. Effects of levobupivacaine on wound healing. Anesth Analg. 2013 Feb;116(2):495-9.

• Ozcan O, Malkoc E, Cosar A, Ipcioglu OM, Gultepe M, Muftuoglu T, Hira S, Ates F. Prolidase enzyme activity in varicose venous walls related to sperm count in patients with varicocele. Scand J Clin Lab Invest. 2013 Mar;73(2):97-101.

• Köksal N, Uzun MA, Ozkan OF, Kayahan M, Ipçioğlu OM, Günerhan Y, Ergün E, Güneş P. Effects of hemoperitoneum on wound healing and fibrinolytic activity in colonic anastomosis. Ulus Travma Acil Cerrahi Derg. 2012 Jul;18(4):283-8.

• Sayan O, Kilicaslan E, Celik S, Tangi F, Erikci AA, Ipcioglu O, Sanisoglu YS, Nalbant S, Oktenli C. High Frequency of Inherited Variants in the MEFV Gene in Acute Lymphocytic Leukemia. Indian J Hematol Blood Transfus. 2011 Sep;27(3):164-8.

• Ozcan O, Ipcioglu OM, Gultepe M. Unexpectedly low asymmetric dimethylarginine (ADMA) and homocysteine levels in patients with phenylketonuria(PKU). J Inherit Metab Dis. 2012 Nov;35(6):1153.

• Ozari HO, Oktenli C, Celik S, Tangi F, Ipcioglu O, Terekeci HM, Top C, Uzun M, Sanisoglu YS, Nalbant S. Are increased carotid artery pulsatility and resistance indexes early signs of vascular abnormalities in young obese males? J Clin Ultrasound. 2012 Jul-Aug;40(6):335-40.

• Sezikli M, Çetinkaya ZA, Güzelbulut F, Çimen B, Özcan Ö, Özkara S, Yeşil A, Gümrükçü G, Ipçioğlu OM, Sezikli H, Ovünç AO. Effects of alpha tocopherol and ascorbic acid on Helicobacter pylori colonization and the severity of gastric inflammation. Helicobacter. 2012 Apr;17(2):127-32.

• Celik S, Oktenli C, Kilicaslan E, Tangi F, Sayan O, Ozari HO, Ipcioglu O, Sanisoglu YS, Terekeci MH, Erikci AA. Frequency of inherited variants in the MEFV gene in myelodysplastic syndrome and acute myeloid leukemia. Int J Hematol. 2012 Mar;95(3):285-90.

• Cekmez F, Canpolat FE, Pirgon O, Çetinkaya M, Aydinoz S, Suleymanoglu S, Ipcioglu OM, Sarici SU. Apelin, vaspin, visfatin and adiponectin in large for gestational age infants with insulin resistance. Cytokine. 2011 Nov;56(2):387-91.

• Meral C, Cekmez F, Vurucu S, Tascılar E, Pirgon O, Canpolat FE, Ipcioglu OM, Aydemir G, Aydınoz S. New adipocytokines (vaspin, apelin, visfatin, adiponectin) levels in children treated with valproic acid. Eur Cytokine Netw. 2011 Jun;22(2):118-22.

• Mutluoğlu M, Uzun G, İpcioğlu OM, Sildiroglu O, Özcan Ö, Turhan V, Mutlu H, Yildiz S. Can procalcitonin predict bone infection in people with diabetes with infected foot ulcers? A pilot study. Diabetes Res Clin Pract. 2011 Oct;94(1):53-6.

• Cekmez F, Canpolat FE, Cetinkaya M, Aydinöz S, Aydemir G, Karademir F, Ipcioglu OM, Sarici SÜ. Diagnostic value of resistin and visfatin, in comparison with C-reactive protein, procalcitonin and interleukin-6 in neonatal sepsis. Eur Cytokine Netw. 2011 Jun;22(2):113-7.

• Cekmez F, Canpolat FE, Çetinkaya M, Pirgon O, Aydinoz S, Ceylan OM, Ipcioglu OM, Sarici SU. IGF-I and visfatin levels in retinopathy of prematurity. J Pediatr Ophthalmol Strabismus. 2012 Mar-Apr;49(2):120-4.

• Umur EE, Oktenli C, Celik S, Tangi F, Sayan O, Sanisoglu YS, Ipcioglu O, Terekeci HM, Top C, Nalbant S, Kucukardali Y. Increased iron and oxidative stress are separately related to cognitive decline in elderly. Geriatr Gerontol Int. 2011 Oct;11(4):504-9.

• Cincik H, Kapucu B, Ipcioglu OM, Gungor A, Dursun E. Hydroxyproline levels in nasal polyps. Eur Arch Otorhinolaryngol. 2011 Aug;268(8):1147-50.

• Sever C, Uygur F, Külahçı Y, Torun Köse G, Urhan M, Küçükodacı Z, Uzun G, Ipçioğlu O, Caycı T. Effect of hyperbaric oxygen therapy on bone prefabrication in rats. Acta Orthop Traumatol Turc. 2010;44(5):403-9.

• Topuz K, Colak A, Cemil B, Kutlay M, Demircan MN, Simsek H, Ipcioglu O, Kucukodaci Z, Uzun G. Combined hyperbaric oxygen and hypothermia treatment on oxidative stress parameters after spinal cord injury: an experimental study. Arch Med Res. 2010 Oct;41(7):506-12.

• Basoglu C, Oner O, Ates AM, Algul A, Semiz UB, Ebrinc S, Cetin M, Ozcan O, Ipcioglu OM. Association between symptom improvement and change of body mass index, lipid profile, and leptin, ghrelin, and cholecystokinin levels during 6-week olanzapine treatment in patients with first-episode psychosis. J Clin Psychopharmacol. 2010 Oct;30(5):636-8.

• Tural E, Meral C, Suleymanoglu S, Karademir F, Aydinoz S, Ozkaya H, Gültepe M, Ipcioglu OM, Gocmen I. Renal zinc clearance/glomerular filtration rate ratio as an indicator of marginal zinc deficiency associated with iron deficiency in childhood. J Am Coll Nutr. 2010 Apr;29(2):107-12.

• Meral C, Tascilar E, Karademir F, Tanju IA, Cekmez F, Ipcioglu OM, Ercin CN, Gocmen I, Dogru T. Elevated plasma levels of apelin in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metab. 2010 May;23(5):497-502.

• Cemil B, Topuz K, Demircan MN, Kurt G, Tun K, Kutlay M, Ipcioglu O, Kucukodaci Z. Curcumin improves early functional results after experimental spinal cord injury. Acta Neurochir (Wien). 2010 Sep;152(9):1583-90; discussion 1590.

• Basoglu C, Oner O, Gunes C, Semiz UB, Ates AM, Algul A, Ebrinc S, Cetin M, Ozcan O, Ipcioglu O. Plasma orexin A, ghrelin, cholecystokinin, visfatin, leptin and agouti-related protein levels during 6-week olanzapine treatment in first-episode male patients with psychosis. Int Clin Psychopharmacol. 2010 May;25(3):165-71.

• Akcakoyun M, Pala S, Esen O, Acar G, Kargin R, Emiroglu Y, Tigen K, Ozcan O, Ipcioglu OM, Esen AM. Dilatation of the ascending aorta is associated with low serum prolidase activity. Tohoku J Exp Med. 2010 Apr;220(4):273-7.

• Uz O, Kardeşoğlu E, Yiğiner O, Baş S, Ipçioğlu OM, Ozmen N, Aparci M, Cingözbay BY, Işilak Z, Cebeci BS. The relationship between coronary calcification and the metabolic markers of osteopontin, fetuin-A, and visfatin. Turk Kardiyol Dern Ars. 2009 Sep;37(6):397-402.

• Uludag M, Ozdilli K, Citgez B, Yetkin G, Ipcioglu OM, Ozcan O, Polat N, Kartal A, Torun P, Isgor A. Covering the colon anastomoses with amniotic membrane prevents the negative effects of early intraperitoneal 5-FU administration on anastomotic healing. Int J Colorectal Dis. 2010 Feb;25(2):223-32.

• Cekmez F, Pirgon O, Tanju A, Ipcioglu OM. Cord plasma concentrations of visfatin, adiponectin and insulin in healthy term neonates: positive correlation with birthweight. Int J Biomed Sci. 2009 Sep;5(3):257-60.

• Gültepe M, Ozcan O, Ipçioğlu OM, Kiralp MZ, Ozçakar L. Sacroiliitis and muscle cramps in a healthy young man: some spearhead on MTHFR mutations. Rheumatol Int. 2010 May;30(7):995-6.

• Kul M, Demirkaya E, Ipçioğlu OM, Karadeniz RS, Tunç T, Vurucu S, Yeşil FG, Oztin H, Cakir E. Perinatal risk factors affecting the maternal and fetal asymmetric dimethylarginine levels. Turk J Pediatr. 2009 Mar-Apr;51(2):141-5.

• Cekin E, Ipcioglu OM, Erkul BE, Kapucu B, Ozcan O, Cincik H, Gungor A. The association of oxidative stress and nasal polyposis. J Int Med Res. 2009 Mar-Apr;37(2):325-30.

• Yonem A, Duran C, Unal M, Ipcioglu OM, Ozcan O. Plasma apelin and asymmetric dimethylarginine levels in type 2 diabetic patients with diabetic retinopathy. Diabetes Res Clin Pract. 2009 Jun;84(3):219-23.

• Dere K, Sen H, Teksoz E, Ozkan S, Dagli G, Sucullu I, Filiz AI, Ipcioglu OM, Kucukodaci Z. The comparison of the effects of different doses of levobupivacaine infiltration on wound healing. J Invest Surg. 2009 Mar-Apr;22(2):112-6.

• Onem Y, Ipcioglu OM, Haholu A, Sen H, Aydinoz S, Suleymanoglu S, Bilgi O, Akyol I. Posttreatment with aminoguanidine attenuates renal ischemia/reperfusion injury in rats. Ren Fail. 2009;31(1):50-3.

• Terekeci HM, Senol MG, Top C, Sahan B, Celik S, Sayan O, Kucukardali Y, Ipcioglu O, Cagiltay E, Oktenli C, Ozata M. Plasma osteoprotegerin concentrations in type 2 diabetic patients and its association with neuropathy. Exp Clin Endocrinol Diabetes. 2009 Mar;117(3):119-23.

• Kayadibi H, Gültepe M, Yasar B, Ince AT, Ozcan O, Ipcioglu OM, Kurdas OO, Bolat B, Benek YZ, Guveli H, Atalay S, Ozkara S, Keskin O. Diagnostic value of serum prolidase enzyme activity to predict the liver histological lesions in non-alcoholic fatty liver disease: a surrogate marker to distinguish steatohepatitis from simple steatosis. Dig Dis Sci. 2009 Aug;54(8):1764-71.

• Yildiz S, Uzun G, Uz O, Ipcioglu OM, Kardesoglu E, Ozcan O. N-terminal pro-B-type natriuretic peptide levels increases after hyperbaric oxygen therapy in diabetic patients. Clin Invest Med. 2008 Oct 1;31(5):E231-5.

• Duran C, Yonem A, Ustun I, Ozcan O, Ipcioglu OM, Basekim CC. Plasma ghrelin levels in males with idiopathic hypogonadotropic hypogonadism. Endocrine. 2008 Aug-Dec;34(1-3):81-6.

• Dundar O, Yoruk P, Tutuncu L, Muhcu M, Ipcioglu O, Ergur AR, Mungen E. Second trimester amniotic fluid annexin A5 levels and subsequent development of intrauterine growth restriction. Prenat Diagn. 2008 Oct;28(10):887-91.

• Onem Y, Kucukardali Y, Sahan B, Atasoyu EM, Ipcioğlu O, Terekeci H, Solmazgul E, Top C, Oktenli C. Analyses of subjects with hypokalemic metabolic alkalosis, Gitelman's and Bartter's syndrome. Ren Fail. 2008;30(7):691-4.

• Ipcioglu OM, Ozcan O, Gultepe M, Ates A, Basoglu C, Cakir E. Reduced urinary excretion of homocysteine could be the reason of elevated plasma homocysteine in patients with psychiatric illnesses. Clin Biochem. 2008 Jul;41(10-11):831-5.

• Suliman ME, Yilmaz MI, Carrero JJ, Qureshi AR, Saglam M, Ipcioglu OM, Yenicesu M, Tong M, Heimbürger O, Barany P, Alvestrand A, Lindholm B, Stenvinkel P. Novel links between the long pentraxin 3, endothelial dysfunction, and albuminuria in early and advanced chronic kidney disease. Clin J Am Soc Nephrol. 2008 Jul;3(4):976-85.

• Ipcioglu OM, Ozcan O, Gultepe M, Deniz O, Akgul EO. Prolidase activity in serum and pleural fluids in patients with tuberculous pleural effusion [correction of effussion]. Clin Biochem. 2008 Jun;41(9):670-5.

• Muhcu M, Mungen E, Atay V, Ipcioglu OM, Dundar O, Ergur R, Yergok YZ. First trimester screening for Down syndrome in rhesus negative women. Prenat Diagn. 2008 May;28(5):404-7.

• Ozcan O, Ipçioğlu OM, Gültepe M, Başoğlu C. Altered red cell membrane compositions related to functional vitamin B12 deficiency manifested by elevated urine methylmalonic acid concentrations in patients with schizophrenia. Ann Clin Biochem. 2008 Jan;45(Pt 1):44-9.

• Sonmez A, Yilmaz MI, Korkmaz A, Topal T, Caglar K, Kaya A, Eyileten T, Yenicesu M, Oguz Y, Basal S, Ipcioglu OM, Vural A. Hyperbaric oxygen treatment augments the efficacy of cilazapril and simvastatin regimens in an experimental nephrotic syndrome model. Clin Exp Nephrol. 2008 Apr;12(2):110-8.

• Gültepe M, Ozcan O, Ipçioglu OM. Assessment of iodine intake in mildly iodine-deficient pregnant women by a new automated kinetic urinary iodine determination method. Clin Chem Lab Med. 2005;43(3):280-4.

Specialty Thesis Topic

• Investigation of the Effects of Iron Intake, Functional Vitamin B12 Deficiency, and ALA Levels on Free Radical Levels in Pregnant Women.