MCF Seher Nazlı Kazaz

Formation et Spécialisation

• 1997–2005 Université Technique de Karadeniz, Faculté de Médecine – Formation Médicale
• 2007–2012 Université Technique de Karadeniz, Faculté de Médecine, Département de Médecine Interne – Doctorat / Spécialisation en Médecine Interne
• 2013–2017 Université Dokuz Eylul, Faculté de Médecine, Division d’Oncologie Médicale – Surspécialité en Oncologie Médicale

Affiliations Scientifiques

• Membre de la Chambre des Médecins de Trabzon (depuis 2007)
• Membre de la Société Turque d’Oncologie Médicale (depuis 2014)
• Membre de l’Association d’Oncologie et d’Immunothérapie (depuis 2017)

Articles publiés dans des revues internationales avec comité de lecture

• Ulusoy S, Ozkan G, Sonmez M, Mungan S, Kaynar K, Cansiz M, Kazaz N. "Absence of hypoalbuminemia despite nephrotic proteinuria in focal segmental glomerulosclerosis secondary to polycythemia vera". Internal Medicine. 2010;49(22):2477-2480.

• Ulusoy S, Ozkan G, Bektaş D, Kaynar K, Cansız M, Kazaz N. "Ramsay Hunt syndrome in a renal transplantation recipient: a case report". Transplantation Proceedings. 2010;42(5):1986-1988.

• Ozkan G, Ulusoy S, Kaynar K, Oztuna F, Cansiz M, Kazaz N. "Swine H1N1 infection in a renal transplant recipient". Experimental and Clinical Transplantation. 2010;8(4):318-320.

• Sonmez M, Kazaz N, Yucel B, Topbas M, Ucar F. "C950T and C1181G osteoprotegerin gene polymorphisms in myeloma bone disease". Hematology. 2014;19(4):213-216.

• Salman T, Kazaz SN, Varol U, Oflazoglu U, Unek IT, Kucukzeybek Y, Alacacioglu A, Atag E, Semiz HS, Cengiz H, Oztop I, Tarhan MO. "Prognostic value of the pretreatment neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for patients with neuroendocrine tumors: An Izmir Oncology Group study". Chemotherapy. 2016;61(6):281-286.

• Atag E, Kazaz SN, Semiz HS, Unek IT, Sarioglu S, Yavuzsen T. "Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the esophagogastric junction and stomach: A case report and review of the literature". Journal of Clinical and Experimental Oncology. 2016;5(6).

• Kurt S, Ulukus C, Kazaz SN, Astarcıoğlu I. "Bilateral ovarian metastasis of a Klatskin tumor: A rare case". Turkish Journal of Obstetrics and Gynecology. 2016;13:215-217.

• Kazaz SN, Oztop I. "Treatment after crizotinib resistance in ALK+ non-small-cell lung cancer". International Journal of Hematology and Oncology. 2017;27(1).

• Kazaz SN, Oztop I. "Treatment after first-generation epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small-cell lung cancer". Turkish Thoracic Journal. 2017;18:66-71.

• Kazaz SN, Oztop I. "Immune checkpoint inhibitors in advanced-stage non-small-cell lung cancer". Turkish Thoracic Journal. 2017;18:101-107.

• Buyruk AM, Kazaz SN, Oztop I, Semiz HS, Oflazoglu U, Somali I. "The use of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV) as inflammatory biomarkers in the prognosis of patients with early-stage colorectal adenocarcinoma". International Journal of Hematology and Oncology. 2017;27(4):220-228.

• Atag E, Semiz HS, Kazaz SN, Tuna EB, Ozdogan O, Bozkurt O, Demir O, Karaoglu A. "Response to cabazitaxel beyond 20 cycles in a patient with penile metastasis of prostate cancer: A case report". Urology Journal. 2017;14(1):2985-2988.

• Eren H, Aydin HR, Tumkaya L, Kazaz IO, Kalkan Y, Kazaz SN, Mercantepe T, Horsanali MO, Yilmaz A. "Whortleberry protects kidney against cisplatin-induced nephrotoxicity: An experimental study". Turkish Journal of Medical Sciences. 2018;40(1):466-474.

• Yildirim S, Kazaz SN, Semiz HS, Yavuzsen T, Somalı I, Ellidokuz H, Oztop I. "An evaluation of the information sources of cancer patients’ relatives: A prospective survey". Journal of Cancer Education. 2019;34:913-919.

• Atag E, Mutlay F, Soysal P, Semiz HS, Kazaz SN, Keser M, Ellidokuz H, Karaoglu A. "Prevalence of depressive symptoms in elderly cancer patients receiving chemotherapy and influencing factors". European Journal of Geriatrics and Gerontology. 2018;18(5):365-370.

• Kazaz IO, Arslan A, Çolak F, Kazaz SN, Mungan S, Karagüzel E. "Bladder metastasis of gastric signet-ring cell carcinoma". Urology Case Reports. 2019;22:62-62.

• Kazaz IO, Ersoz S, Colak F, Teoman AS, Kazaz SN, Karaguzel E, Kutlu O. "Primary renal angiosarcoma: A case report and a short review of the literature". Indian Journal of Pathology and Microbiology. 2020;63(5):44-46.

• Semiz HS, Kazaz SN, Demir N, Güç ZG, Yavuzşen T, Ellidokuz H, Oztop I, Somalı I. "Prognostic significance of hematological parameters in patients with early-stage malignant melanoma". UHOD – International Journal of Hematology and Oncology. 2020;30(2):103-109.

• Kazaz IO, Özgür GK, Çobanoğlu Ü, Kalyoncu Nİ, Karagüzel E, Topbaş M, Eren H, Kazaz SN, Özyavuz R. "Investigation of the effects of tadalafil and telmisartan in bleomycin-induced pulmonary fibrosis in rats". Journal of Surgery and Medicine. 2020;4(8):689-692.

• Fidan E, Yildirim A, Kazaz N, Fidan S, Cekic AB. "The relationship between albumin-bilirubin score and survival in patients operated for pancreatic cancer". Journal of Pakistan Medical Association. 2022;72(7):1340-1344.

• Kazaz SN, Yıldırım A. "Evaluation of knowledge, attitudes and behaviours about COVID-19 among cancer patients". Annals of Clinical and Analytical Medicine. 2022;13(4):389-393.

• Aynacı Ö, Serdar L, Rakıcı S, Kazaz S, Canyılmaz E, Bahat Z, Zengin AY. "Radiotherapy in cancer treatment during the COVID-19 pandemic: One-year results from Northeast Turkey". Turkish Journal of Oncology. 2022;37(2):200-207.

• Dişli Ş, Fidan E, Özdover A, Kazaz N, Özdemir F. "Complementary and alternative treatment use in breast cancer patients in the Eastern Black Sea region: A cross-sectional study". Indian Journal of Medical and Paediatric Oncology. 2022;43:270-277.

• Fidan E, Fidan S, Merev E, Kazaz N. "The relationship between albumin–bilirubin grade and survival in hepatocellular carcinoma patients treated with sorafenib". Nigerian Journal of Clinical Practice. 2022;25(2):173-177.

Livres ou chapitres de livres internationaux/nationaux

• Yavuzsen T, Kazaz N, Tanriverdi O, Akman T, Davis MP. "Symptom Management in Gastrointestinal Cancers". In: Textbook of Gastrointestinal Oncology. 2019.

• Kazaz SN, Oztop I. "Thyroid Diseases – Systemic Treatments and Side Effects in Thyroid Cancer". In: Radionuclide Therapy. 2019.

• Kazaz SN, Oztop I. "Neuroendocrine Tumors – Systemic Treatments and Side Effects in Neuroendocrine Tumors". In: Radionuclide Therapy. 2019.

• Kazaz SN, Aydın F. "Systemic Treatment in Cervical Cancer". In: Türkiye Klinikleri Special Issue – Gynecological Cancers. 2019.

• Kazaz SN, Oztop I. "The Future of Lung Cancer". In: Türkiye Klinikleri Special Topics – Medical Oncology: Lung Cancer. 2020.

• Kazaz SN, Oztop I. "Adjuvant Treatment in Rectal Cancer". In: Türkiye Klinikleri Special Topics – Radiation Oncology: Multidisciplinary Treatment of Rectal Cancer. 2020.

• Kazaz SN, Yavuzşen T. "Scales in Geriatric Oncology". In: Geriatric Oncology.

• Kazaz SN, Oztop I. "Tyrosine Kinase Inhibitors in Geriatric Lung Cancer Patients". In: Geriatric Oncology.

• Yıldırım Dişli Ş, Kazaz SN, Özdemir F. "Chemotherapy in Oral Cavity Cancers". In: Türkiye Klinikleri – Ear, Nose and Throat – Special Topics: Oral Cavity Tumors.

• Kazaz SN, Fidan Evren. "Follow-Up and Prognosis in Hormone Receptor-Positive HER-2 Negative Breast Cancer". In: TTOD – Breast Cancers.

• Öztop I, Kazaz SN. "Systemic Treatments and Related Side Effects in Thyroid Cancer". In: Radionuclide Therapy. Springer, 2022.

• Öztop I, Kazaz SN. "Systemic Treatments and Related Side Effects in Neuroendocrine Tumors". In: Radionuclide Therapy. 2022.

Articles publiés dans des revues nationales avec comité de lecture

• Keser M, Kazaz SN, Karaoglu A. "Medullary Thyroid Cancer". Türkiye Klinikleri Journal of Medical Oncology – Special Topics. 2017;10(1):91–96.

• Semiz HS, Kazaz N, Karaoglu A. "Adjuvant and Neoadjuvant Systemic Treatment in Lung Cancer". Türkiye Klinikleri Journal of Thoracic Surgery – Special Topics. 2017;8(1):264–271.

• Alandag C, Kazaz SN, Cobanoglu B. "Adenoid Cystic Carcinoma: A Single-Center 15-Year Experience". EJMI. 2021;5(4):491–495.

Communications présentées lors de réunions scientifiques internationales

• Sonmez M, Kazaz N, Yucel B, Topbas M, Ucar F. "C950T and C1181G Osteoprotegerin Gene Polymorphisms in Myeloma Bone Disease". ASH 55th Annual Meeting. Blood 2013.

• Yavuzsen T, Demir N, Oflazoglu U, Kazaz N, et al. "HER2 Protein Over-Expression in Early Stage Gastric Cancer: Correlation with Clinicopathological Features and Survival". ESMO 17th World Congress on Gastrointestinal Cancer. Annals of Oncology 2015.

• Unek IT, Kazaz SN, Semiz HS, Atag E, et al. "Good Response to Panitumumab, Capecitabine and Oxaliplatin Combination (P-CapeOX) Regimen in a Patient with Liver Metastasis from Colon Cancer". 4th International Gastrointestinal Cancer Conference.

• Semiz HS, Unek IT, Demir N, Atag E, Oflazoglu U, Kazaz SN, Somali I, Oztop I. "Combination of Capecitabine and Vinorelbine for the Treatment of Synchronous Lung and Rectum Cancers". 4th International Gastrointestinal Cancer Conference.

• Demir N, Unek IT, Oflazoglu U, Kazaz SN, Semiz HS, Atag E, Yavuzsen T, Somali I, Oztop I. "Stomach Cancer in Adolescents and Young Adults: A Single Center Experience". 4th International Gastrointestinal Cancer Conference.

• Kazaz SN, Unek IT, Demir N, Oflazoglu U, Atag E, Semiz HS, et al. "Pancreatic Ductal Adenocarcinoma in Young Adults: A Report of Four Cases". 4th International Gastrointestinal Cancer Conference.

• Atag E, Unek IT, Demir N, Oflazoglu U, Kazaz SN, Semiz HS, et al. "Synchronous Appearance of Gastric Carcinoma, Colon Carcinoma, and Renal Cell Carcinoma". 4th International Gastrointestinal Cancer Conference.

• Atag E, Semiz HS, Kazaz SN, Demir N, Oflazoglu U, Unek IT, et al. "FOLFOXIRI and Bevacizumab Regimen as a Second-Line Therapy: A Case Report". 4th International Gastrointestinal Cancer Conference.

Communications présentées lors de réunions scientifiques nationales

• Özkan G, Ulusoy Ş, et al. "Swine H1N1 Infection in a Renal Transplant Recipient". 12th National Hypertension and Kidney Diseases Congress. 2010.

• Özkan G, Ulusoy Ş, et al. "Ramsey-Hunt Syndrome in a Renal Transplant Recipient". 12th National Hypertension and Kidney Diseases Congress. 2010.

• Özkan G, Ulusoy Ş, et al. "Focal Segmental Glomerulosclerosis Secondary to Polycythemia Vera". 27th National Nephrology Congress. 2010.

• Kazaz SN, Köseoğlu R, et al. "Prognostic Impact of Early Decrease in Leukocyte count with Chemotherapy in AML". 38th National Hematology Congress. 2012.

• Atag E, et al. "Pathological and Clinical Features of Geriatric Breast Cancer Patients". 1st Geriatric Oncology Congress. 2014.

• Demir N, et al. "Ipilimumab-Induced Autoimmune Hypophysitis". 1st Geriatric Oncology Congress. 2014.

• Kazaz N, et al. "Assessment of Frailty using the G-8 Questionnaire". 1st Geriatric Oncology Congress. 2014.

• Oflazoğlu U, et al. "ALK Rearrangement Results and Clinicopathological Characteristics". 10th National Oncological Research Workshop. 2014.

• Kazaz SN, et al. "Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Colon". 2nd Rare Tumors Symposium. 2015.

• Salman T, et al. "Tubular Gastrointestinal Neuroendocrine Tumors: A Two-Center Study". 2nd Rare Tumors Symposium. 2015.

• Semiz HS, Kazaz SN, Öztop I. "Excellent Survival in Metastatic Malignant Melanoma". 3rd National Immuno-Oncology Congress. 2016.

• Atag E, et al. "Pulmonary Blastoma: A Rare Lung Tumor in a Young Patient". 4th Rare Tumors Symposium. 2017.

• Yıldırım Dişli Ş, Kazaz SN. "Abiraterone Acetate and Enzalutamide in Geriatric mCRPC Patients". 4th Geriatric Oncology Congress. 2020.

• Kazaz SN. "Efficacy and Adverse Effects of Immunotherapy in Geriatric Cancer Patients". 4th Geriatric Oncology Congress. 2020.

• Yıldırım A, Kazaz SN. "Metastatic Lung Adenocarcinoma with Concurrent EGFR Mutation and ALK Rearrangement". 4th Young Perspectives in Oncology Congress.

Congrès et réunions en tant qu'oratrice

• Kazaz SN. "İmmunoterapide Yan Etki Yönetimi – Kardiyak Yan Etkileri ve Yönetimi". 5th Symposium on Pursuits in Oncology. 2016.

• Kazaz SN. "Akciğer Adenoca Çok Basamak Kemoterapi Almış Hastada İmmunoterapi". 1st National Oncology with Clinical Cases Congress. 2016.

• Kazaz SN. "Akciğer Kanserinde Hedefe Yönelik ve İmmunoonkolojik Tedaviler – ROS, MEK". 4th Black Sea Oncology Symposium. 2017.

• Kazaz SN. "Tirozin Kinaz İnhibitör Tedavilerinde Yan Etki Yönetimi". 6th Symposium on Pursuits in Oncology. 2017.

• Kazaz SN. "Akılcı İlaç Kullanımı". 2nd Eskişehir Oncology Days. 2019.

• Kazaz SN. "Perioperatif Kemoterapi: Neoadjuvan–Adjuvan". Eurasian Urooncology Meeting. 2019.

• Kazaz SN. "Perioperatif Sistemik İmmunoterapi: Nereye Gidiyoruz?". Eurasian Urooncology Meeting. 2019.

• Kazaz SN. "İmmunoterapilerde Yan Etki Yönetimi". Turkish Society of Medical Oncology Course. 2019.

• Kazaz SN. "Metastatic Malign Melanomda İmmunoterapi". 6th Black Sea Oncology Symposium. 2019.

• Kazaz SN. "KHDAK’nin Moleküler Temelli Tedavisinde Beklentiler". 8th Symposium on Pursuits in Oncology. 2019.

• Kazaz SN. "Meme Kanserinde Neoadjuvan Tedavi: Kime?". 4th Black Sea Surgical Days. 2020.

• Kazaz SN. "mKRK’inde İdeal Tedavi için Sıralama". 4th Young Perspectives in Oncology Congress. 2021.

• Kazaz SN. "Prostat Kanserinde Hormon Tedavisinde Yenilikler". 5th Course on Immuno-Oncological Treatments. 2021.

• Kazaz SN. "Multidisipliner Tümör Konseyi: Akciğer Kanserleri". 8th TTOK. 2021.

• Kazaz SN. "KHDAK’de Biyobelirteçlerin Takip ve Tedavideki Yeri". 9th Symposium on Pursuits in Oncology. 2021.

• Kazaz SN. "Metastatik KHDAK’nde Nadir Mutasyonlarda Güncel Yaklaşım". 3rd Eskişehir Oncology Days. 2022.

• Kazaz SN. "Ürogenital Kanserlerde Yeni Tedaviler, Prostat Kanseri". 7th Black Sea Oncology Days. 2022.

Participation aux cours de formation

• Karadeniz Technical University. "Rational Drug Selection and Use Course". 2004.

• Karadeniz Technical University. "Kidney Transplant Pathology Course". 2009.

• Turkish Society of Medical Oncology. "Head and Neck & CNS Cancers Course". 2014.

• Turkish Society of Medical Oncology. "Thoracic Oncology Western Region Course". 2014.

• Turkish Society of Medical Oncology. "Sarcomas and Dermatological Cancers Course". 2014.

• Dokuz Eylül University. "Pharmacovigilance and Adverse Reaction Reporting Training". 2015.

• Immuno-Oncology Association. "Malignant Melanoma Course". 2015.

• Klinikum Oldenburg (Germany). "Diagnosis and Treatment of Metastatic Colorectal Cancer". 2015.

• KTÜKAM. "Good Clinical Practices (GCP) Course". 2019.

Participation aux essais cliniques (Investigatrice)

• PERTAIN (NCT01491737)

• PERUSE (NCT01572038)

• HERiTAge Protocol MYL-HER-3001 (NCT02472964)

• ASQoP (NCT01571284)

• ExteNET (NCT00878709)

• D-CARE (NCT01077154)

• Javelin Lung 200 (NCT02395172)

• MK-3475-KEYNOTE-905 (NCT03924895)

• MK-3475-KEYNOTE-866 (NCT03924856)

• Tislelizumab (BGB-A317) + Chemotherapy (NCT03777657) — Principal Investigator

• MK-3475-KEYNOTE-992 (NCT04241185) — Principal Investigator

• BLC 2002 NORSE (NCT03473743) — Principal Investigator

• CBYL719K12301 — Principal Investigator

Participations aux congrès

• 1st National Gastrointestinal Oncology Congress, Avril 3–5, 2009, Antalya.

• 1st Symposium on Targeted Therapies in Cancer, Juin 17–19, 2011, Trabzon.

• 9th European International Kidney Cancer Symposium (EIKCS), Avril 25–26, 2014, Dublin, Irlande.

• Turkish Society of Medical Oncology – Best of ASCO 2014 Annual Meeting, Juin 21–22, 2014, Istanbul.

• İzmir Oncology Group – 1st Rare Tumors Symposium, Février 28–Mars 2, 2014, İzmir.

• İzmir Oncology Group – 2nd Rare Tumors Symposium, Février 27–Mars 1, 2015, İzmir.

• 21st National Cancer Congress, Avril 22–26, 2015, Antalya.

• 2nd Immuno-Oncology and Targeted Cancer Therapies Congress, Mai 13–17, 2015, Antalya.

• 2nd Geriatric Oncology Congress, Octobre 20–23, 2016, Antalya.

• 7th National Lung Cancer Congress, Novembre 24–27, 2016, Antalya.

• 25th Year Symposium on Multidisciplinary Approach to Cancer – Dokuz Eylül Experience, Novembre 11–12, 2016, İzmir.

• 5th Symposium on Advances in Oncology, Novembre 4–6, 2016, İzmir.

• 15th St. Gallen International Breast Cancer Conference 2017, Mars 15–18, 2017, Vienne, Autriche.

• 3rd Geriatric Oncology Congress, Novembre 9–11, 2018, Antalya.

• 23rd National Cancer Congress, Avril 17–21, 2019, Antalya.

• ESMO 2019, Septembre 27–Octobre 1, 2019, Barcelone, Espagne.

• EMUC 2019 – 11th European Multidisciplinary Congress on Urological Cancers, Novembre 14–17, 2019, Vienne, Autriche.

• ASCO 2020 – New Developments and Updates, TTOD Sessions, Juin 1–5, 2020, e-Congress.

• 4th National Immunotherapy and Oncology Congress, Octobre 29–Novembre 1, 2020 (Session Chair).

• ESMO 2020, e-Congress.

• ASCO 2020, e-Congress.

• TAKD 2021, e-Congress.

• ASCO 2021, e-Congress.

• 10th World Melanoma Congress, 2021, e-Congress.

• 5th National Immunotherapy and Oncology Congress, Octobre 13–17, 2021 (Session Chair).

• 8th TTOK Congress.

• 9th Symposium on Advances in Oncology.

• 3rd Eskişehir Oncology Days.

• 7th Black Sea Oncology Days.

• 9th TTOK Congress.

• 6th National Immunotherapy and Oncology Congress, Octobre 19–23, 2022.

Données de citations et impact

• Total des citations : 156

• h-index : 7

• i-10 index : 5

Publications sélectionnées citées

• Response to Cabazitaxel Beyond 20 Cycles in a Patient with Penile Metastasis of Prostate Cancer: A Case Report. Atag E, Semiz HS, Kazaz SN, et al. Urology Journal, 2017. (Citations : 1)

• Prognostic Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for Patients with Neuroendocrine Tumors. Salman T, Kazaz SN, et al. Chemotherapy, 2015. (Citations : 7)

• C950T and C1181G Osteoprotegerin Gene Polymorphisms in Myeloma Bone Disease. Sonmez M, Kazaz N, et al. Hematology, 2014. (Citations : 3)

• Absence of Hypoalbuminemia Despite Nephrotic Proteinuria in Focal Segmental Glomerulosclerosis Secondary to Polycythemia Vera. Ulusoy S, Ozkan G, Sonmez M, Kazaz N, et al. Internal Medicine, 2010. (Citations : 4)

• Treatment After First-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small-Cell Lung Cancer. Kazaz SN, Oztop I. Turkish Thoracic Journal, 2017. (Citations : 1)