Prof. Dr.Hüseyin İlksen Toprak

  • İlgi Alanları
  • Karaciğer nakli anestezisi
  • Koagülasyon monitörizasyonu yönetimi
  • Hasta kan yönetimi
  • Hemodinamik monitörizasyon
  • Düşük akım anestezi

Eğitim ve Uzmanlık
1986-1992 Ege Üniversitesi Tıp Fakültesi, Dr.
1992-1997 Malatya Hekimhan Verem Savaşı Dispanseri, Pratisyen Hekim
1997-2001 İnönü Üniversitesi Tıp Fak. Anesteziyoloji ve Reanimasyon Anabilim Dalı, Uzm. Dr.
2001-2007 İnönü Üniversitesi Tıp Fak. Anesteziyoloji ve Reanimasyon Anabilim Dalı, Dr. Öğr. Üyesi
2007-2013 İnönü Üniversitesi Tıp Fak. Anesteziyoloji ve Reanimasyon Anabilim Dalı, Doç. Dr
2013-2021 İnönü Üniversitesi Tıp Fak. Anesteziyoloji ve Reanimasyon Anabilim Dalı, Prof.Dr
2021- İstanbul Aydın Üniversitesi Tıp Fak. Anesteziyoloji ve Reanimasyon Anabilim Dalı, Prof.Dr

Deneyim
2012 King College Liver Transplantation Clinic
2016 Essen Ü. Liver Transplantation Clinic

Yabancı Dil
İngilizce

Mesleki Üyelikler
Türk Anesteziyoloji ve Reanimasyon Derneği
Türk Yoğun Bakım Derneği
Türk Göğüs Kalp Damar Anestezi ve Yoğun Bakım Derneği

Araştırma ve Yayınlar

A1. Turkoz A., T. Togal, R. Gokdeniz, H. I. Toprak and O. Ersoy, “Effectiveness of Intravenous Ephedrine Infusion During Spinal Anaesthesia for Caesarean Section Based on Maternal Hypotension, Neonatal Acid-base Status and Lactate Levels”, Anaesth Intensive Care, 30, 316-320 (2002).

A2. Türköz A., İ.H. Toprak, A. Köroğlu, M. Durmuş, A.K. But and M.Ö. Ersoy, “Anesthetic Management and Endovascular Stent Grafting of Abdominal Aortic Aneurysm in A Patient with Behçet’s Disease (Case Report)”, J Cardiothorac Vasc Anesth, 16, 468-470 (2002).

A3. Durmus M., A. Turkoz, T. Togal, A. Koroglu, H.I. Toprak and M.O. Ersoy, “Remifentanil and Acute Intermittent Porphyria (Correspondence)”, Eur J Anaesth, 19, 839-840 (2002).

A4. Turkoz A., H.I. Toprak, M.O. Ersoy, O. Gulcan and R. Turkoz, “Secondary Cross-Clamping and Blood Cardioplegia for Refractory Ventricular Fibrillation After Aortic Cross-Clamp Removal”, Tex Heart Inst J, 29, 230-231 (2002).

A5. Erdil N., V. Nisanoglu, H.I. Toprak, F.A. Erdil, A. Kuzucu and B Battaloglu, “Arterial Myocardial Revascularization Using Bilateral Radial Artery. 17 Years After Right Pneumonectomy”, Tex Heart Inst J, 31, 96-98 (2004).

A6. Toprak H.İ., E. Gedik, Z. Begeç, E. Öztürk, B. Kaya and M.Ö. Ersoy, “Sevoflurane: As An Alternative Anaesthetic for Electroconvulsive Therapy”, J ECT, 21, 108-110 (2005).

A7. But A.K., M. Durmus, H.I. Toprak, E. Ozturk, S. Demirbilek and M.O. Ersoy, “Hemodynamic, Hepatorenal, and Postoperative Effects of Desflurane-Fentanyl and Midazolam-Fentanyl Anesthesia in Coronary Artery Bypass Surgery”, J Cardiothorac Vasc Anesth, 19, 597-602 (2005).

A8. Toprak H.İ., Z. Ozpolat, E. Ozturk, M.H. Ulger, O. Sagir and M.O.Ersoy, “Hyperbaric Bupivacaine Affects the Doses of Midazolam Required for Sedation After Spinal Anaesthesia”, Eur J Anaesth, 22: 904-906 (2005).

A9. Koroglu A., H. Teksan, O. Sagir, A. Yucel, H.I. Toprak and M.O. Ersoy, “A Comparison of the Sedative, Hemodynamic, and Respiratory Effects of Dexmedetomidine and Propofol in Children Undergoing Magnetic Resonance Imaging”, Anesth Analg, 103, 63-7 (2006).

A10. But A.K., U. Ozgul, F. Erdil, N. Gulhas, H.I. Toprak, M. Durmus and M.O.Ersoy, “The Effects of Pre-operative Dexmedetomidine Infusion on Hemodynamics in Patients with  Pulmonary Hypertension Undergoing Mitral Valve Replacement Surgery”, Acta Anaesthesiol Scand, 50, 1207–1212 (2006).

A11. Sagir O., N. Gulhas, H. Toprak, A. Yucel, Z. Begec and M.O. Ersoy, “Control of Shivering during Regional Anaesthesia: Prophylactic Ketamine and Granisetron”, Acta Anaesthesiol Scand, 51, 44–49 (2007).

A12. Durmus M., A.K. But, V. Saricicek, H.I. Toprak and M.O. Ersoy, “The Post-operative Analgesic Effects of a Combination of Gabapentin and Paracetamol in Patients Undergoing Abdominal Hysterectomy: A Randomized Clinical Trial”, Acta Anaesthesiol Scand, 51, 299-304 (2007).

A13. Ugras Y.M., H.I. Toprak, H. Gunen, A. Yucel and A. Gunes, “Instillation of Skin, Nephrostomy Tract and Renal Puncture Site with Ropivacaine Decreases Pain and Improves Ventilatory Function After Percutaneous Nephrolithotomy”, J Endourol, 21, 499-503 (2007).

A14. Begec Z, N. Gulhas, H.I. Toprak, G. Yetkin, C. Kuzucu and M.O. Ersoy, “Comparison of the Antibacterial Activity of Lidocaine 1% Versus Alkalinized Lidocaine In Vitro”, Curr Ther Res Clin Exp, 68, 242-248 (2007).

A15. Koroglu A., M. Cicek, H.I. Toprak, Y. Karakoc, F. Noyan and O.M. Ersoy, “Comparison of the Effects of Desflurane and Sevoflurane on the Expression of Platelet Surface Glycoproteins in Unstimulated and Adenosine Diphosphate-Induced Platelets in-vitro”, J Clin Anesth, 19, 328-333 (2007).

A16. Begec Z, H.I. Toprak, S. Demirbilek, F. Erdil, D. Onal and M.O. Ersoy, “Dexmedetomidine blunts acute hyperdynamic responses to electroconvulsive therapy without altering seizure duration”, Acta Anaesthesiol Scand, 52, 302-306 (2008).

A17. Begec Z, S. Demirbilek, D. Onal, F. Erdil, H.I. Toprak and M.O. Ersoy, “Ketamine or alfentanil administration prior to propofol anaesthesia: the effects on ProSeal laryngeal mask airway insertion conditions and haemodynamic changes in children”, Anaesthesia, 64, 282-286 (2009).

A18. Togal T, N. Yucel, E. Gedik, N. Gulhas, H.I. Toprak and M.O. Ersoy, “Obstetric admissions to the intensive care unit in a tertiary referral hospital”, Journal of Critical Care, 25, 628-633 (2010).

A19. Toprak H.İ., A. Şener, E. Gedik, M. Uçar, K. Karahan, M.S. Aydogan and M.Ö. Ersoy, “Bispectral Index Monitoring to Guide End-Tidal Isoflurane Concentration at Three Phases of Operation in Patients With End-Stage Liver Disease Undergoing Orthotopic Liver Transplantation”, Transplantation Proceedings, 43, 892-5 (2011).

A20. Toprak H.I., T. Şahin, S. Aslan, K. Karahan, M. Sanli and M.Ö. Ersoy, “Effects of desflurane and isoflurane on hepatic and renal functions and coagulation profile during donor hepatectomy”, Transplantation Proceedings, 44, 1635-39 (2012).

A21. Ozen I, T. Togal, M.S. Aydogan, M.A. Erdogan, H. Nakir, N. Gulhas, H.I. Toprak and M.O. Ersoy, “Thromboelastographic comparison of the effects of different fluid preloading regimens delivered before spinal anesthesia”, HealthMED, 6: 3488-94 (2012).

A22. Sagir O, F. Yucesoy Noyan, A. Koroglu, M. Cicek and H.I. Toprak, “Comparison between the effects of rocuronium, vecuronium, and cisatracurium using train-of-four and clinical tests in elderly patients”, Anesthesiology and Pain Medicine, 2: 142-8 (2013).

A23. Begeç Z, G. Erdoğan Kayhan, H.İ. Toprak, T. Şahin, H. Konur, C. Çolak, M. Durmuş and M.Ö. Ersoy, “Sevoflurane alone and propofol with or without remifentanil for electroconvulsive therapy—a randomised, crossover study” Anaesth Intensive Care, 41, 202-206 (2013).

A24. Şahin T., Z. Begeç, H.I. Toprak, A. Polat, N. Vardi, A. Yücel, M. Durmus and M.Ö. Ersoy, “The Effects of Dexmedetomidine on Liver Ischemia-Reperfusion Injury in Rats”, J Surg Res, 183, 385-390 (2013).

A25. Akbulut S., C. Kayaalp, M. Yilmaz, V. Ince, D. Ozgor, K. Karabulut, C. Eris, HI. Toprak, C. Aydin and S. Yilmaz, “Effect of autotransfusion system on tumor recurrence and survival in hepatocellular carcinoma patients”, World J Gastroenterol, 19: 1625-1631 (2013).

A26. Aydogan MS., U. Ozgül, MA Erdogan, N. Gülhas, HI Toprak, M. Durmus, “Intraoperative Anaphylactic Shock Due to Latex Allergy: Case Report”, Medicine Science, doi: 10.5455/medscience.2013.02.8055.

A27. Ozgul U, M. Ucar, MA. Erdogan, MS. Aydogan, HI. Toprak, C. Colak, M. Durmus and MO. Ersoy, “Effects of isoflurane and propofol on hepatic and renal functions and coagulation profile after right hepatectomy in living donors”, Transplant Proc, 45: 966-70 (2013).

A28. Aydogan MS, U. Ozgül, MA. Erdogan, A. Yucel, HI. Toprak, M. Durmus and C. Colak, “Effect of preoperative iron deficiency in liver transplant recipients on length of intensive care unit stay”, Transplant Proc, 45: 978-81 (2013).

A29. Aydogan MS, MA. Erdogan, A. Yucel, H. Konur, R. Bentli, HI. Toprak and M. Durmuş, “Effects of Preoperative Iron Deficiency on Transfusion Requirements in Liver Transplantation Recipients: A Prospective Observational Study”, Transplant Proc, 45: 2277-2282 (2013).

A30. Yilmaz S, C. Kayaalp, C. Ara, M. Yilmaz, B. Isik, C. Aydin, D. Ozgor, A. Dirican, B. Barut, B. Unal, T. Piskin, M. Ates, R. Kutlu, HI. Toprak, Y. Bayindir, H. Kirimlioglu, M. Aladag, M. Harputluoglu, A. Selimoglu, H. Karabiber, K. Yalcin and V. Kirimlioglu, “Single-Center Analysis of the First 304 Living-Donor Liver Transplantations in 3 Years”, Hepatogastroenterology, 60: 1105-9 (2013).

A31. Bucak N, Z. Begec, F. Erdil, H.İ. Toprak, B. Elbozan Cumurcu, Y. Demirtaş, S. Yoloğlu, M. Durmuş and M.Ö. Ersoy, “Postoperative Cognitive Dysfunction in Living Liver Transplant Donors”, Experimental and Clinical Transplantation, Suppl 1: 81-85 (2014).

A32. Ucar M, U. Ozgül, A. Polat, H.I. Toprak, M.A. Erdogan, M.S. Aydogan, M. Durmus,  and M.O. Ersoy, “Comparison of Antioxidant Effects of Isoflurane and Propofol in Patients Undergoing Donor Hepatectomy”, Transplant Proc, 47: 469-472 (2015).

A33. Bicakcioglu M, M.S. Aydogan, H. Sayan, H.I. Toprak, B. Isik, S. Yılmaz, and S. Yologlu, “Effects of Different Positive End-Expiratory Pressure Values on Liver Function and Indocyanine Green Clearance Test in Liver Transplantation Donors: A Prospective, Randomized, Double-Blind Study”,  Transplant Proc, 47: 1190-1193 (2015).

A34. Sayan H, M.S. Aydogan, M. Bicakcioglu, H.I. Toprak, B. Isık, and S. Yılmaz, “Effects of Thoracic Epidural Anesthesia on Liver Blood Flow and Indocyanine Green Clearance Test in Living-Donor Liver Transplantation: A Prospective, Randomized, Double-Blind Study”, Transplant Proc, 47: 1462-1465 (2015).

A35. Demir A, B. Aydınlı, H.I. Toprak, Ü. Karadeniz, F.M. Yılmaz, C. Züngün, P. Uçar, Ç.Y. Güçlü, E.B. Bostancı, and S. Yılmaz, “Impact of 6% Starch 130/0.4 and 4% Gelatin Infusion on Kidney Function in Living-Donor Liver Transplantation”, Transplant Proc, 47: 1883-1889 (2015).

A36. Gedik E, M. Bıçakçıoğlu, E. Otan, H. İlksen Toprak, B. Işık, C. Aydın, C. Kayaalp, S. Yılmaz, “The 2-stage liver transplant: 3 clinical scenarios”, Exp Clin Transplant, 13 (Suppl 1): 286-9 (2015).

A37. Gedik E, H. İlksen Toprak, E. Koca, T. Şahin, Ü. Özgül, MÖ. Ersoy, “Blood glucose regulation during living-donor liver transplant surgery”, Exp Clin Transplant, 13 (Suppl 1): 294-300 (2015).

A38. Ince V, F. Ozdemir, Y. Bayindir, HI Toprak, M. Harputluoglu, R. Kutlu, B. Isik, C. Kayaalp, S. Yilmaz, “Liver Transplant in Patients with Viral Hepatitis and Human Immunodeficiency Virus Coinfection: The First 2 Cases in Turkey”, Exp Clin Transplant, doi: 10.6002/ect.2015.0036. (2016).

A.39. Konur H, G. Erdogan Kayhan, HI. Toprak, N. Bucak, MS Aydogan, S. Yologlu, M. Durmus, S. Yılmaz, “Evaluation of pleth variability index as a predictor of fluid responsiveness during orthotopic liver transplantation”, Kaohsiung Journal of Medical Sciences, 32: 373-80 (2016).

A.40. Kıtlık A, MA. Erdogan, U. Ozgul, MS. Aydogan, M. Ucar, HI Toprak, C. Colak, M. Durmus, “Ultrasound-guided transversus abdominis plane block for postoperative analgesia in living liver donors: A prospective, randomized, double-blinded clinical trial”, J Clin Anesth, 37: 103-7 (2017).

A.41. Piskin T, B. Unal, K. Kutluturk, IO. Yildirim, B. Berktas, SM. Dogan, J. Yagmur, EI. Coskun,
I. Turkcuoglu, A. Beytur, M. Sanli, YZ. Colak, G. Otlu, H. Taskapan, I. Sahin, Y. Tabel, U. Kayabas, K. Sarac, and H.I. Toprak, “Outcomes of Kidney Transplantations From the Same Deceased Donor to Two Different Recipients: A Single-Center Experience”, Transplantation Proceedings, 49, 460-463 (2017).

A42. Erdoğan MA, U. Ozgul, M. Ucar, M.R. Yalin, Y.Z. Colak, C. Colak and H.I. Toprak, “Effect of transversus abdominis plane block in combination with general anesthesia on perioperative opioid consumption, hemodynamics, and recovery in living liver donors: The prospective, double-blinded, randomized study, Clin Transplant, 31 (2017). (doi: 10.1111/ctr.12931).

A43. Erdogan Kayhan G, YZ. Colak, M. Sanli, M. Ucar, H.I. Toprak, “Accuracy of non-invasive hemoglobin monitoring by pulse CO-oximeter during liver transplantation”, Minerva Anesthesiologica, 83, 485-492 (2017).

A44. Habre W, Disma N, Virag K, Becke K, Hansen TG, Jöhr M, Leva B, Morton NS, Vermeulen PM, Zielinska M, Boda K, Veyckemans F; APRICOT Group of the European Society of Anaesthesiology Clinical Trial Network, “Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe”, Lancet Respir Med, 5: 412-425 (2017). (doi: 10.1016/S2213-2600(17)30116-9. Epub 2017 Mar 28.)

A45. Ince V, C. Kayaalp, E. Otan, F. Ozdemir, A. Dirican, H.I. Toprak, C. Aydin, C. Ara, S. Yilmaz, “Living Donor Re-transplantation for Repeated Acute Liver Failure”, Int J Org Transplant Med; 9: 50-2 (2018).

A46. Ertugay S, T. Kudsioğlu, T. Şen, A. Yıldırır, A.H. Vural, A. Demir, E.U. Ünal, H.İ. Toprak, and Patient Blood Management Study Group Members, “Consensus Report on Patient Blood Management in Cardiac Surgery by Turkish Society of Cardiovascular Surgery (TSCVS), Turkish Society of Cardiology (TSC), and Society of Cardio-Vascular-Thoracic Anaesthesia and Intensive Care (SCTAIC)”, Turk Gogus Kalp Damar Cerrahisi Derg, 27: 429-450 (2019).

A47. Colak Y.Z., H.I. Toprak, “Feasibility, safety, and economic consequences of using low flow anesthesia according to body weight”, J Anesth, 34: 537–542 (2020). (DOI: 10.1007/s00540-020-02782-y)

A48. Unal D, Senayli Y, Polat R, Spahn DR, Toraman F, Alkis N; Turkish Society of Anaesthesiology and Reanimation Patient Blood Management Group; Turkish National Perioperative Transfusion Study, “Peri-operative blood transfusion in elective major surgery: incidence, indications and outcome. An observational multicentre study”, Blood Transfus, 18: 261-279 (2020). doi: 10.2450/2020.0011-20.

A49. Weiss R, K. Saadat-Gilani, L. Kerschke, C. Wempe, M. Meersch , A. Zarbock, the EPIS-AKI Investigators, “EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): study protocol for a multicentre, observational trial”, BMJ Open, 11:e055705 (2021).

A50. Colak Y.Z., H.I. Toprak, “Feasibility, safety, and economic consequences of using minimal flow anaesthesia by Maquet FLOW-i equipped with automated gas control”, Sci Rep, 11: 20074 (2021).

A51. Zarbock A, R. Weiss, F. Albert, K. Rutledge, JA. Kellum, R Bellomo, E Grigoryev, AM Candela-Toha, ZA Demir, V Legros, P Rosenberger, P Galán Menéndez, M Garcia Alvarez, K Peng, M Léger, W Khalel, M Orhan-Sungur, M Meersch; The EPIS-AKI Investigators, “Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study”, Intensive Care Med. 2023 Jul 28. doi: 10.1007/s00134-023-07169-7. Epub ahead of print. PMID: 37505258, (2023).

A52. Demiroz D, YZ Colak, OO Ozdes, M Ucar, MA Erdogan, Hİ Toprak, S. Karakas, SD Tasolar, C Aydın, I Varol, “Incidence and risk factors of acute kidney injury in pediatric liver transplant patients: A retrospective study”, Indian Journal of Critical Care Medicine: 10.5005/jp-journals-10071-24616 (2024).

A53. Meersch M, R. Weiss, C. Straub, F. Albert, H. Booke, L Forni, JF Pittet, JA Kellum, M Rosner, R Mehta, R Bellomo, P Rosenberger, A Zarbock, on behalf of the EPIS-AKI Investigators, “Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial”, Intensive Care Med, doi.org/10.1007/s00134-023-07314-2 (2024).