Doç. Dr.Mutlu Karkucak

  • İlgi Alanları
  • Moleküler genetik
  • Sitogenetik
  • Klinik genetik
  • Genetik danışmanlık
  • Preimplantasyon genetik tanı
  • Kanser genetiği

Eğitim ve Uzmanlık
2006 - İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi – Tıp Eğitimi
2010 - Uludağ Üniversitesi Tıp Fakültesi Hastanesi, Tıbbi Genetik A.D.- Tıbbi Genetik Uzmanlık Eğitimi
2014 - T.C. Sağlık Bakanlığı Sakarya Üniversitesi Eğitim ve Araştırma Hastanesi, Tıbbi Genetik- Doç. Dr.

Deneyim
2006 - 2010 - Uludağ Üniversitesi Tıp Fakültesi, Tıbbi Genetik A.D. (Araştırma Görevlisi Doktor)
2010 - 2011 - T.C. Sağlık Bakanlığı Sakarya Üniversitesi Eğitim ve Araştırma Hastanesi (Tıbbi Genetik Uzmanı)
2011 - 2012 - Ankara Gülhane Askeri Tıp Akademisi, Tıbbi Genetik A.D. (Yedek Subay-Tıbbi Genetik Uzmanı)
2012 - 2017 - T.C. Sağlık Bakanlığı Sakarya Üniversitesi Eğitim ve Araştırma Hastanesi (Tıbbi   Genetik Uzmanı)
2019 - Halen - İstinye Üniversitesi Genetik Hastalıklar Tanı Merkezi (Tıbbi   Genetik Uzmanı)

Mesleki Üyelikler
Tıbbi Genetik Derneği
Türk Tabipler Birliği
Moleküler Kanser Araştırma Derneği (MOKAD)
European Association for Cancer Research(EACR)

Ödüller
9. Uludağ Pediatri Kış Kongresi, Bursa, Türkiye, Mart 2013 (Poster Bildirisi 1.Lik Ödülü).
6. Uludağ İç Hastalıkları Kış Kongresi, Bursa, Türkiye, Mart 2010 (Poster Bildirisi 1.Lik Ödülü).
V. Ege Dermatoloji Günleri (Türk–Yunan Dermatoloji Sempozyumu), Muğla, Türkiye, Mayıs 2009 (Sözlü Bildiri 1.Lik Ödülü).
5. Uludağ İç Hastalıkları Kongresi, Bursa, Türkiye, Nisan 2009 (Poster Bildiri 1.Lik Ödülü).
22. Ulusal Dermatoloji Kongresi, Konya, Türkiye, Ekim 2008 (Sözlü Bildiri 1.Lik Ödülü).

A1. J.M. Bastida, S. Morais, V. Palma-Barqueros, R. Benito, N. Bermejo, M. Karkucak, M. Trapero-Marugan, N. Bohdan, M. Pereira, A. Marin-Quilez, J. Oliveira, Y. Yucel, R. Santos, J. Padilla, K. Janusz, C. Lau, M. Martin-Izquierdo, E. Couto, J. Francisco Ruiz-Pividal, V. Vicente, J.M. Hernández-Rivas, J.R. González-Porras, M. Luisa Lozano, M. Lima, J. Rivera. Identification of novel variants in ten patients with Hermansky-Pudlak syndrome by high-throughput sequencing. Ann Med., 51(2):141-148, 2019.

A2. M.F. Öksuz, M. Karkucak, O. Görukmez, G. Ocakoğlu, A. Yıldız, M. Ture, T. Yakut, K. Dilek. Investigation of MEFV gene polymorphisms (G138G and A165A) in adult patients with familial mediterranean fever, Rev Bras Reumatol Engl Ed. Nov - Dec;57(6):501-506, 2017.

A3. F. Coskun, M. Karkucak, D. Yilmaz, T. Yakut, E. Uzaslan. GSTT1 and GSTM1 gene polymorphisims in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. Oct 7;33(3):253-257, 2016.

A4. H. Aydemir, M. Karkucak, H.I. Cimen, F. Halis, S. Kumsar, A.E. Sonbahar, T. Yakut. A rare combination of 45,X/46,XY mosaicism and Y chromosome microdeletion in an infertile man with azoospermia, Genet Couns., 27(1):95-98, 2016.

A5. O. Gorukmez, T. Yakut, O Gorukmez, SO Sag, M. Karkucak, O. Kanat. Distribution of KRAS and BRAF Mutations in Metastatic Colorectal Cancers in Turkish Patients. Asian Pac J Cancer Prev., 17(3):1175-1179, 2016.

A6. B. Solak, M. Karkucak, H. Turan, G. Ocakoğlu, Ş.Ö. Sağ, E. Uslu, T. Yakut, T. Erdem. Glutathione S-Transferase M1 and T1 Gene Polymorphisms in Patients with Chronic Plaque-Type Psoriasis: A Case-Control Study. Medical Principles and Practice,  Med Princ Pract. 25(2):155-158, 2016.

A7. S. Yesilkaya, M. Karkucak, H.Coban, A. Ursavas, M. Ture, T. Yakut. Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Pulmonary Thromboembolism. International Journal of Human Genetics, 15(4): 183-189, 2015.

A8. S. Ozemri Sag, T. Yakut, O. Gorukmez, O. Gorukmez, M. Ture, M. Karkucak, T. Gulten, R. Ali. Qualitative and Quantitative Evaluation of the BCR-ABL Fusion Gene in Chronic Myelogenous Leukemia by Flourescence In Situ Hybridization and Molecular Genetic Methods. Genetic Testing and Molecular Biomarkers, 19(10):584-588, 2015.

A9. A.B. Ayaz, M. Karkucak, M. Ayaz, S. Gokce, E. Kayan, E.E. Güler, B.D. Güngen, T.D. Kuşcu, G. Ocakoğlu, T. Yakut. Oxytocin system social function impacts in children with attention-deficit/hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 168(7):609-616,2015.

A10. M. Karkucak, B. Solak, H. Turan, E. Uslu, T. Yakut, C. Aliagaoglu, T. Erdem. MBL2 Gene Polymorphism and Risk of Vitiligo in Turkish Patients. International Journal of Human Genetics, 15(3): 93-96, 2015.

A11. M. Ture, T. Yakut, A. Deligonul, M. Karkucak, S. Ozemri Sag, M. Hartavi, E. Cubukcu, T. Gulten, T. Evrensel. Investigation of FGFR4 (Gly388Arg) Gene Polymorphism in Primary Lung Cancer Patients. International Journal of Human Genetics, 15(1): 7-12, 2015.

A12. D. Nak, T. Gulten, M. Karkucak, R. Yilmaz, Y. Nak, G. Simsek, A.H. Shahzad. SRY-negative XX sex reversal in an English Cocker Spaniel: a case report. Veterinarni Medicina, 60(3): 170-173, 2015.

A13. O. Orhan, M.A. Atalay, F. Orhan, M. Karkucak, B.C. Demir, T. Yakut, C. Cengiz. Glutathione S-Transferase M1 and T1 Gene Polymorphisms are not Associated with Increased Risk of Gestational Diabetes Mellitus Development. West Indian Medical Journal, 63(4): 304-310, 2014. 

A14. S. Cander, M. Karkucak, O.O. Gul, S.O. Sag, T. Yakut, C. Ersoy, E. Tuncel, E. Erturk. Association between p16(CDKN2A) C540G polymorphism and tumor behavior in prolactinoma: A single-center study. Biomedical Reports. 2(4):589-595, 2014.

A15. H. Turan, M. Karkucak, T. Yakut, M. Ozsahin, Z. Gurlevik, M.E. Yanik, T. Ucgun, C. Aliagaoglu, O.K. Yaykasli. Does MBL-2 codon 54 polymorphism have a role in psoriasis pathogenesis? International Journal of Dermatology.53(1): 34-38, 2014.

A16. M. Cinar, H. Akar, S. Yılmaz, I. Simsek, M. Karkucak, R. Ilikci Sagkan, A. Pakel H. Erdem, I.Y. Avcı, C. Acikel, U. Musabak, Y. Tunca, S. Pay. A polymorphism in ERAP1 is associated with susceptibility to ankylosing spondylitis in a Turkish population. Rheumatology International (Clinical and Experimental Investigations), 33(11):2851-2858, 2013.

A17. T. Tos, S. Vurucu, M. Karkucak, S. Kozan, D. Gul, R Akin. Subtelomeric fish findings in Turkish patients with idiopathic mental retardation. Genetic counseling, 24(3):259-264, 2013.

A18. K. Ozerkan, M.A. Atalay, T. Yakut, Y. Doster, E. Yilmaz, M. Karkucak. Polymorphisms of glutathione s-transferase M1, T1 and P1 genes in endometrial carcinoma. European Journal of Gynaecological  Oncology, 34(1):42-47,2013.

A19. T.Gulten, O.Gorukmez, O.Gorukmez, M. Karkucak, M. Ture, T. Yakut. Another Small Supernumerary Marker Chromosome Derived from Chromosome 9 in a Klinefelter Patient. West Indian Medical Journal, 61(9):924-927,2012.

A20. D. Yilmaz, M. Karkucak, F. Coskun, T. Yakut, E. Uzaslan. Türk sarkoidoz hastalarında ACE gen polimorfizmi ve sarkoidoz gelişme riski. Tüberküloz ve Toraks Dergisi 60: 201-206, 2012.

A21. M. Karkucak, E. Bulbul Baskan, H. Turan, T. Yakut, S. Toka, H. Saricaoglu. Investigation of Mannose-binding Lectin gene Polymorphism in Patients with Erythema Multiforme, Stevens-Johnson Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome. Balkan Medical Journal. 29(3): 310-313,2012.

A22. M. Karkucak , T. Yakut , T. Gulten, R. Ali. Investigation of GSTP1 (Ile105Val) Gene Polymorphism in Chronic Myeloid Leukaemia Patients. International Journal of Human Genetics.12(3): 145-149, 2012.

A23. S. Cander, E. Erturk, M. Karkucak, O.O. Gul, O. Gorukmez, T. Yakut, O.K. Unal, C. Ersoy, E. Tuncel, S. Imamoglu. Effect of Cycline D1 (CCND1) Gene Polymorphism on Tumor Formation and Behavior in Patients With Prolactinoma. Gene 509(1):158–163, 2012.

A24. M. Karkucak, T. Yakut, V. Ozkocaman, F. Ozkalemkas, R. Ali, M. Bayram, O. Gorukmez, G. Ocakoglu. Evaluation of the JAK2-V617F gene mutation in Turkish patients  with essential thrombocythemia and polycythemia vera. Molecular Biology Reports 39(9): 8663–8667, 2012.

A25. M. Karkucak, T. Yakut, T. Evrensel, A. Deligonul, T. Gulten, G. Ocakoglu, E. Kurt, O. Kanat, E. Cubukcu, I. Sehitoglu, M. Canhoroz. XRCC1 Gene Polymorphisms and Risk of Lung Cancer in Turkish Patients. International Journal of Human Genetics.12(2): 113-117, 2012.

A26. M. Karkucak, O. Gorukmez, T. Yakut, B. Baytan, O. Gorukmez, A.M. Gunes. Molecular Cytogenetic Findings in Cases with Childhood Acute Lymphoblastic Leukemia. UHOD-Uluslararasi Hematoloji-Onkoloji Dergisi. 22(2):67-72, 2012.

A27. T. Yakut, M. Karkucak , G. Sher, L. Keskintepe. Comparison of aneuploidy frequencies between in vitro matured and unstimulated cycles oocytes by metaphase Comparative Genomic Hybridization (mCGH). Molecular Biology Reports. 39(5):6187–6191, 2012.

A28. M. Karkucak, T. Yakut, B. Baytan, T. Gulten, A.M. Guneş. Variant Translocation of ABL1 Gene t(2;9)(q21;q34) in a Childhood T-Cell Acute Lymphoblastic Leukemia:  a case report and review of the literature. Bratislava Medical Journal-Bratislavske Lekarske Listy. 113(1):19-20, 2012.

A29. M. Karkucak, T. Yakut, B. Baytan, T. Gulten, A.M. Gunes. Childhood Acute Lymphoblastic Leukemia with Near-Tetraplody and t(12; 21) (p13;q22) Translocation; A Case Report. UHOD-Uluslararasi Hematoloji-Onkoloji Dergisi.  21(3):192-195, 2011.

A30. H. Turan, E. Bulbul Baskan, T. Yakut, M. Karkucak, S. Tunali, H. Saricaoglu. Toll-Like Receptor 9 Polymorphism in Patients with Erythema Multiforme, Stevens Johnson Syndrome and Stevens Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome. Bratislava Medical Journal-Bratislavske Lekarske Listy. 112(5):260-263, 2011.

A31. H. Saricaoglu, M. Yilmaz, M. Karkucak, H.Z. Yazici Ozturk, T. Yakut, T. Gulten, E. Bulbul Baskan, K. Aydogan, K. Dilek. Investigation of ABCB1 gene polymorphism with colchicine response in Behçet’s Disease. Genetics and Molecular Research(ISI). 10: 1-6, 2011.

A32. M. Karkucak, S. Sag, T. Yakut, Y. Kimya. Prenatal diagnosis of De Novo reciprocal translocation t(1;12)(q21.3;p11.2)  with trisomy 21 and sperm FISH  analysis for increased aneuploidy risk. International Journal of Human Genetics. 10(4): 231-234, 2010.

A33. B. Kiran, M. Karkucak, H. Ozan, T. Yakut, K. Ozerkan, S. Sag, M. Ture. GST (GSTM1, GSTT1 and GSTP1) polymorphisms in the genetic susceptibility of Turkish patients to cervical cancer. Journal of Gynecologic Oncology. 21(3):169-173, 2010.

A34. H. Cangul, N.V. Morgan, J.R. Forman, H. Saglam, Z. Aycan, T. Yakut, T. Gulten, O. Tarim, E. Bober, Y. Cesur, G.A. Kirby, S. Pasha, M. Karkucak, E. Eren, S. Cetinkaya, V. Bas, K. Demir, S.A. Yuca, E. Meyer, M. Kendall, W. Hogler, T.G. Barrett, E.R. Maher. Novel TSHR mutations in consanguineous families with congenital nongoitrous hypothyroidism. Clinical Endocrinology.73(5):671-677, 2010.

A35. S. Tanır, M. Karkucak, T. Yakut, S.S. Kilic. Toll like receptor-9 gene polymorphism in common variable immunodeficiency. Journal of Investigational Allergology and Clinical Immunology. 20(3):267-268, 2010.

A36. T. Yakut, M. Karkucak, A. Ursavas, T. Gulten, B. Burgazlioglu, O. Gorukmez, M. Karadag. Lack of association of ACE gene I/D polymorphism in Turkish patients with Obstructive Sleep Apnea Syndrome. Genetics and Molecular Research.  9(2):734-738,2010.

A37. R. Ali, F. Ozkalemkas, V. Ozkocaman, T. Yakut, H.O. Nazlioglu, F. Budak, M. Pekgoz, S. Korkmaz, M. Karkucak, T. Ozcelik, A. Tunali. Sudden blastic crisis and additional chromosomal abnormalities during chronic myeloid leukemia in the imatinib era. International Journal of Clinical Oncology. 14(6):545-550, 2009.

A38. T. Gulten, T. Yakut, M. Karkucak, B. Baytan, A.M. Gunes. AML1 amplification and 17q25 deletion in a case of childhood acute lymphoblastic leukemia. Journal of Clinical Laboratory Analysis. 23(6):368-371, 2009.