Prof. Dr.Zeynep Ocak

  • İlgi Alanları
  • Klinik genetik
  • Moleküler genetik
  • Sitogenetik
  • Kanser genetiği
  • Genetik danışmanlık
  • İmmunogenetik
  • Preimplantasyon genetik tanı

Eğitim ve Uzmanlık
2001 - Atatürk Üniversitesi Tıp Fakültesi– Tıp Eğitimi
2007 - Atatürk Üniversitesi Tıbbi Genetik A.D.- Tıbbi Genetik Uzmanlık Eğitimi
2011 - Abant İzzet Baysal Üniversitesi Tıp Fakültesi Tıbbi Genetik A.D.- Yrd. Doç. Dr.
2014 - Abant İzzet Baysal Üniversitesi Tıp Fakültesi Tıbbi Genetik A.D.- Doç. Dr.
2019 - İstinye Üniversitesi Tıp Fakültesi Tıbbi Genetik A.D. – Doç. Dr.

Deneyim
2003-2007- Atatürk Üniversitesi Tıbbi Genetik A.D.- Arş.Gör.Dr.
2008-2011- Süleymaniye Doğum ve Kadın Hastalıkları Eğitim ve Araştırma Hastanesi -Tıbbi Genetik Uzmanı
2011-2013- Abant İzzet Baysal Üniversitesi Tıp Fakültesi Tıbbi Genetik A.D.- Yrd. Doç. Dr.
2013-2014- Research Center for Genomic Medicine, Saitama Medical University, Saitama           350-1241,Japan-Researcher
2014-2016- Kanuni     Sultan  Süleyman        Eğitim  ve        Araştırma Hastanesi – Doç. Dr.
2016-2017- Dışkapı Yıldırım Beyazıt Eğitim   ve        Araştırma Hastanesi Transplantasyon İmmünolojisi, Doku Tipleme ve Transplantasyon Laboratuvarı – Doç. Dr.
2017-2019- Yeni Yüzyıl Üniversitesi Tıp Fakültesi Tıbbi Biyoloji ve Genetik A.D.– Doç. Dr.
2019-Halen – İstinye Üniversitesi Tıp Fakültesi Tıbbi Genetik A.D. –Doç. Dr.

Mesleki Üyelikler
Tıbbi Genetik Derneği
Türk Tabipler Birliği

Ödüller
Poster II.’lik ödülü: Tatar A, Döneray H, Ocak Z, Marzioğlu E ve Öztaş S, “Mozaik olmayan         49, XYYYY karyotipli bir vaka,” VIII Ulusal Tıbbi Genetik Kongresi, 284, Çanakkale, 2008
Yayın Teşvik Programı Ödülü, Abant İzzet Baysal Üniversitesi Araştırma ve Geliştirme Vakfı, 2013
Genç araştırmacı ödülü, European Human Genetics Conference, Vienna, Austria,2009
Genç araştırmacı ödülü, 13th Int. Congress of Human Genetics, Kyoto, Japan, 2016

Uluslararası hakemli dergilerde yayımlanan makaleler:


A1. Oztas S, Salman AB, Tatar A, Yigiter M, Yazgi H, Ertek M, Yesilyurt A, Ocak Z, Kürşat H. Genotoxic effect of albendazole in pediatric patients with hepatic hydatid disease. International Journal of Infectious Disease 2007; 11: 446-449

A2. Tatar A, Ocak Z, Doneray H, Isık E, Yesilyurt A, Ozkan B, Oztas S: Seckel syndrome with spontaneous chromosomal instability: a case report, Turkish Journal of Medical Sciences 2008; 38: 77-81

A3. Tatar A, Ocak Z, Tatar A, Yesilyurt A, Borekci B, Oztas S. Primary hypogonadism, partial alopecia, and mullerian hypoplasia: report of a third family and review. American journal of medical genetics. Part A 2009; 149A, 501-504

A4. Yazıcıoglu F, Ocak Z. Walker-Warburg syndrome with hyperplastic primary vitreus detected by prenatal ultrasonography: case report. Ultrasound in Obstetrics and Gynecolgy 2010; 35: 247-249

A5. Ocak Z, Surucu R. Molecular cytogenetic characterization of a case of primary amenorrhea with intrachromosomal triplication of the X chromosome q arm. Genetic counseling. 2012;23: 297-304.

A6. Ocak Z, Göksügür S.B, Kocaman E.M. Dirençli epilepsi olgusunda mozaik ring kromozom 6 ve klinik önemi. Turkish Archives of Pediatrics 2012; 47: 315-6

A7. Ocak Z, Yazıcıoğlu HF, Aygün M, Ilter MKI, Ozlu T. Prenatal detection of Pai syndrome without cleft lip and palate: a case report. Genetic counseling. 2013; 24: 1-5

A8. Ocak T, Ocak Z, Duran A, Bilgi M, Demirhan A, Şit M. The approach to the case of rarely seen adult morque syndrome at emergency service. South Eastern Europe Health Sciences Journal 2013; 3: 93-6.

A9. Ocak Z, Ocak T, Duran A, Ozlü T, Kocaman E.M. Frequency of MEFV mutation and genotype-phenotype correlation in cases with dysmenorrhea. The Journal of Obstetrics and Gynaecology Research 2013; 8:1314-8

A10. Ocak Z, Ozlu T, Vural M. Anal atresia, abnormal genitalia and absent thumb: congenital malformations associated with mosaic ring chromosome 13. Genetic counseling 2013; 24: 157-60

A11. Ocak Z, Ozlü T, Ozyurt O. The association of recurrent pregnancy loss with chromosomal abnormalities and hereditary thrombophilias. The African Health Sciences 2013; 13: 465-70

A12. Ocak Z, Acar M, Gundüz E, Gundüz M, Demircan K, Uyeturk U, Ozlü T. Effect of hypericin on the ADAMTS-9 and ADAMTS-8 gene expression in MCF7 breast cancer cells. European Review for Medical and Pharmacological Sciences 2013; 17: 1185-90

A13. Baris I, Etlik O, Koksal V, Ocak Z, Baris ST. SYBR green dye-based probe-free SNP genotyping: introduction of T-Plex real-time PCR assay. Anal Biochem. 2013; 441: 225- 31.

A14. Dınçer M, Karahasanoglu A, Çılıngır U, Ozdemır M.E, Ocak Z, Karahuseyınoglu S, Yucel O, Frequency of Y chromosome microdeletions and chromosomal abnormalities in infertile Turkish men. Genet Couns. 2013; 24: 431-4.

A15. Tarik O, Zeynep O, Hasan D, Mustafa U, Ahmet Y, Mevlit I, Sahin A. Relationship between carbon monoxide intoxication and sister chromatid Exchange in lymphocytes. Toxicol Ind Health. 2014; 10: 896-900

A16. Ocak Z, Üyetürk U, Dinçer M. Clinical and prognostic importance of chromosomal abnormalities, Y chromosome microdeletions and CFTR gene mutations in the individuals who have azoospermia and severe oligospermia. Turkish Journal of Medical Sciences 2014; 2:347-51.

A17. Ocak Z, Ozlü T, Yazıcıoğlu H.F, Aygün M, Özyurt O. Clinical and cytogenetic results of a large series of amniocentesis cases from turkey: report of 6124 cases. The Journal of Obstetrics and Gynaecology Research 2014; 1:139-46.

A18. Özlü T, Ocak Z, Ozyurt O. Prenatal diagnosis of Pallister Killian syndrome in a fetus with congenital diaphragmatic hernia, short limbs and ıncreased nuchal translucency. Taiwanese Journal of Obstetrics and Gynecology 2014; 3: 404-5

A19. Ocak T, Duran A, Özyalvaçli G, Ocak Z, Terzi H.E, Tosun M, Erdem K. Protective effects of montelukast and hypericum perforatum against ıntestinal ıschemia-reperfusion ınjury in hamsters. Turkish Journal of Medical Sciences 2014; 3: 381-6.

A20. Ocak Z, Özlü T, Tasdemir S, Bilen H, Kocaman E.M. Are there any genotoxic effects of laser epilation applications on human? An observational study. Natl J Physiol Pharm Pharmacol. 2014; 1: 43-46

A21. Ozlü T, Ocak Z, Serap Simavlı A, Karatas A. Polymorphisms of Toll Like Receptor 2,3 and 4 in patients that do and do not enter labor spontaneously at term. Journal of Obstetrics and Gynaecology 2014; 6: 476-8

A22. Acar M, Ocak Z, Erdogan K, Cetin EN, Hatipoglu OF, Uyeturk U, Gunduz E, Gunduz M. The effects of hypericin on ADAMTS and p53 gene expression in MCF-7 breast cancer cells. J BUON. 2014; 3: 627-32.

A23. Gulec EY, Ocak Z, Candan S, Ataman E, Yarar C. Novel mutations in PTPN11 gene in two girls with Noonan syndrome phenotype. Int J Cardiol. 2015; 19;186:13-15.

A24. Simavli H, Tosun M, Bucak Y, Erdurmus M, Ocak Z, Onder H, Acar M. Serum and aqueous xanthine oxidase levels, and mRNA expression in anterior lens epithelial cells in pseudoexfoliation, Graefes Arch Clin Exp Ophthalmol 2015; 253:1161–7

A25. Aldemir S, Acar M, Ocak Z, Dalbudak E, Yiğitoğlu M.R, Gündüz E. Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with obsessive-compulsive disorder in a Turkish population.  Klınık Psıkofarmakolojı Bultenı-Bulletın Of Clınıcal Psychopharmacology 2016;(baskıda)

A26. Bornaun H. Oztarhan K, Ocak Z, Ulucan K, Buyukkale K, Gedikbası A.  Contribution      of TGFB1 and TNF-alpha genes in one of twin pregnancy with congenital complete heart block phenotype" International Journal of Cardiology 2016; 210:16-8

A27. Özan Ü, Ocak Z, Özan F, Oktay EA, Toptaş O, Şahman H, Yikilgan I, Oruçoğlu H, Er K. Association of Toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risk. Med Oral Patol Oral Cir Bucal. 2016; 21(4): e408-12.

A28. Pehlivan D, Bayram Y, Gunes N, Coban Akdemir Z, Shukla A, Bierhals T, Tabakci B, Sahin Y, Gezdirici A, Fatih JM, Gulec EY, Yesil G, Punetha J, Ocak Z, Grochowski CM, Karaca E, Albayrak HM, Radhakrishnan P, Erdem HB, Sahin I, Yildirim T, Bayhan IA, Bursali A, Elmas M, Yuksel Z, Ozdemir O, Silan F, Yildiz O, Yesilbas O, Isikay S, Balta B, Gu S, Jhangiani SN, Doddapaneni H, Hu J, Muzny DM; Baylor-Hopkins Center for Mendelian Genomics, Boerwinkle E22, Gibbs RA, Tsiakas K, Hempel M, Girisha KM, Gul D, Posey JE, Elcioglu NH, Tuysuz B, Lupski JR. The Genomics of Arthrogryposis, a Complex Trait: Candidate Genes and Further Evidence for Oligogenic Inheritance. Am J Hum Genet. 2019 Jul 3;105(1):132-150.